22 research outputs found
Topological mechanochemistry of graphene
In view of a formal topology, two common terms, namely, connectivity and
adjacency, determine the quality of C-C bonds of sp2 nanocarbons. The feature
is the most sensitive point of the inherent topology of the species so that
such external action as mechanical deformation should obviously change it and
result in particular topological effects. The current paper describes the
effects caused by uniaxial tension of a graphene molecule in due course of a
mechanochemical reaction. Basing on the molecular theory of graphene, the
effects are attributed to both mechanical loading and chemical modification of
edge atoms of the molecule. The mechanical behavior is shown to be not only
highly anisotropic with respect to the direction of the load application, but
greatly dependent on the chemical modification of the molecule edge atoms thus
revealing topological character of the graphene deformation.Comment: 9 pages, 10 figures, 1 table. arXiv admin note: text overlap with
arXiv:1301.094
Protective effects of combined Losartan and Nilotinib on carbon tetrachloride (CCl4)-induced liver fibrosis in rats
Tyrosine kinase inhibitors (TKIs) have been developed as therapeutic compounds for inhibiting the progression of liver fibrosis. In the present study, the simultaneous treatment of Nilotinib (TKIs) and Losartan was studied. Forty rats were divided into eight groups of fibrosis induced by carbon tetrachloride (CCl4) and therapeutics (Nilotinib, Losartan, and combination therapy). In the end, serum parameters of the liver and gene expression analysis of transforming growth factor-β1, its receptors (TβRII), platelet-derived growth factor, its receptors (PDGFRβ), matrix metalloproteinases (MMP-2 and MMP-9), tumor necrosis factor-α, cytochrome P450 2E1, and collagen1 type 1 were performed. The oxidant/antioxidant factors were also analyzed. Histopathology analysis along with α-SMA immunohistochemistry and hydroxyproline evaluation was also conducted for a more in-depth study. The overall results indicated a better therapeutic effect of co-treatment of Nilotinib–Losartan in comparison with the treatment of each of them alone. Interestingly, some gene and protein factors and fibrotic indices were reduced even to the normal levels of the control group. The results of this study suggest that co-administration of these two combinations, strengthens their anti-fibrotic properties and, due to the routine use of these compounds against AML and blood pressure, these compounds can be used with caution against human liver fibrosis. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group