A Facile Strategy for In Situ Core-Template-Functionalizing Siliceous Hollow Nanospheres for Guest Species Entrapment

The shell wall-functionalized siliceous hollow nanospheres (SHNs) with functional molecules represent an important class of nanocarriers for a rich range of potential applications. Herein, a self-templated approach has been developed for the synthesis of in situ functionalized SHNs, in which the biocompatible long-chain polycarboxylates (i.e., polyacrylate, polyaspartate, gelatin) provide the framework for silica precursor deposition by simply controlling chain conformation with divalent metal ions (i.e., Ca2+, Sr2+), without the intervention of any external templates. Metal ions play crucial roles in the formation of organic vesicle templates by modulating the long chains of polymers and preventing them from separation by washing process. We also show that, by in situ functionalizing the shell wall of SHNs, it is capable of entrapping nearly an eightfold quantity of vitamin Bc in comparison to the bare bulk silica nanospheres. These results confirm the feasibility of guest species entrapment in the functionalized shell wall, and SHNs are effective carriers of guest (bio-)molecules potentially for a variety of biomedical applications. By rationally choosing the functional (self-templating) molecules, this concept may represent a general strategy for the production of functionalized silica hollow structures

Posterior arch anomalies of Atlas and its clinical significance

Introduction: Congenital anomalies of posterior arch of atlas are very rare. Most of the time detection of this developmental anomaly is incidental while investigating for neck pain and stiffness or injury involving the region of head and neck. Aim: Our aim was to determine the incidence of posterior arch anomaly of atlas in Maharashtra region. 75 dried human atlas vertebrae were included for this study. Observations: We detected Type A and B in our study. Results: The incidence of posterior arch anomaly is 4% i.e. 3 out of 75 vertebrae. We detected Type A and B in our study and these types are generally asymptomatic. Type C to E may be associated with neurological deficit. Conclusion: It is essential for the clinicians to recognize the condition and the specific type of anomaly in order to distinguish it from fractures secondary to trauma and for the proper guidance of the patients accordingly

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