On the characterization of the heterogeneous mechanical response of human brain tissue

The mechanical characterization of brain tissue is a complex task that scientists have tried to accomplish for over 50 years. The results in the literature often differ by orders of magnitude because of the lack of a standard testing protocol. Different testing conditions (including humidity, temperature, strain rate), the methodology adopted, and the variety of the species analysed are all potential sources of discrepancies in the measurements. In this work, we present a rigorous experimental investigation on the mechanical properties of human brain, covering both grey and white matter. The influence of testing conditions is also shown and thoroughly discussed. The material characterization performed is finally adopted to provide inputs to a mathematical formulation suitable for numerical simulations of brain deformation during surgical procedures.</p

Problems associated with quantitative fetal blood flow measurements

Peer Reviewe

An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models

To study and characterize the in vivo effect of the lectin from Luetzelburgia auriculata seed on acute inflammation models. The lectin was purified from the crude saline extract by affinity chromatography on a guar-gum matrix. Native, heat-treated, and digested lectin was evaluated for anti-inflammatory activity by using peritonitis and paw edema models. The anti-inflammatory activity was characterized by intravital microscopy, nitric oxide production, and myeloperoxidase activity. The lectin exhibited anti-inflammatory activity (2 mg/kg) on both models, reducing local myeloperoxidase activity. Galactose or heat treatment (100A degrees C, 10 min) reduced anti-inflammatory action. Anti-inflammation involves the inhibition of adhesion and rolling of leukocytes along with augmentation of nitric oxide in serum. The lectin inhibited the edematogenic effect of histamine and prostaglandins (PGE2) but did not alter the chemoattractant effect of IL-8. The results indicate that this lectin is a potent anti-inflammatory molecule. Its effects engage diverse modulatory events.International Foundation for Science[IFS 3070-2]Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq

Can Machines Design? An Artificial General Intelligence Approach

International audienceCan machines design? Can they come up with creative solutions to problems and build tools and artifacts across a wide range of domains? Recent advances in the field of computational creativity and formal Artificial General Intelligence (AGI) provide frameworks for machines with the general ability to design. In this paper we propose to integrate a formal computational creativity framework into the Gödel machine framework. We call the resulting framework design Gödel machine. Such a machine could solve a variety of design problems by generating novel concepts. In addition, it could change the way these concepts are generated by modifying itself. The design Gödel machine is able to improve its initial design program, once it has proven that a modification would increase its return on the utility function. Finally, we sketch out a specific version of the design Gödel machine which specifically addresses the design of complex software and hardware systems. Future work aims at the development of a more formal version of the design Gödel machine and a proof of concept implementation