21 research outputs found
Diabetes mellitus as presenting feature in extra-adrenal pheochromocytoma: Report of a case
No full textCirculating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients: The Graz Endocrine Causes of Hypertension study
No full textActivation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
No full textSummary: Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and patient samples, we show that AML LICs are sensitive to endogenous and exogenous cyclopentenone prostaglandin-J (CyPG), Δ12-PGJ2, and 15d-PGJ2, which are increased upon dietary selenium supplementation via the cyclooxygenase-hematopoietic PGD synthase pathway. CyPGs are endogenous ligands for peroxisome proliferator-activated receptor gamma and GPR44 (CRTH2; PTGDR2). Deletion of GPR44 in a mouse model of AML exacerbated the disease suggesting that GPR44 activation mediates selenium-mediated apoptosis of LICs. Transcriptomic analysis of GPR44−/− LICs indicated that GPR44 activation by CyPGs suppressed KRAS-mediated MAPK and PI3K/AKT/mTOR signaling pathways, to enhance apoptosis. Our studies show the role of GPR44, providing mechanistic underpinnings of the chemopreventive and chemotherapeutic properties of selenium and CyPGs in AML
Gene and Protein Sequence Optimization for High-Level Production of Fully Active and Aglycosylated Lysostaphin in Pichia pastoris
No full textSerum insulin, insulin antibodies and insulin requirement in the first period of insulin treatment in non-insulin resistant diabetics
No full textJapanese/U.S. technological competitiveness and strategic alliances in the biotechnology industry
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