Kinetics of A+B--->0 with Driven Diffusive Motion

We study the kinetics of two-species annihilation, A+B--->0, when all particles undergo strictly biased motion in the same direction and with an excluded volume repulsion between same species particles. It was recently shown that the density in this system decays as t^{-1/3}, compared to t^{-1/4} density decay in A+B--->0 with isotropic diffusion and either with or without the hard-core repulsion. We suggest a relatively simple explanation for this t^{-1/3} decay based on the Burgers equation. Related properties associated with the asymptotic distribution of reactants can also be accounted for within this Burgers equation description.Comment: 11 pages, plain Tex, 8 figures. Hardcopy of figures available on request from S

Kaon Zero-Point Fluctuations in Neutron Star Matter

We investigate the contribution of zero-point motion, arising from fluctuations in kaon modes, to the ground state properties of neutron star matter containing a Bose condensate of kaons. The zero-point energy is derived via the thermodynamic partition function, by integrating out fluctuations for an arbitrary value of the condensate field. It is shown that the vacuum counterterms of the chiral Lagrangian ensure the cancellation of divergences dependent on $\mu$, the charge chemical potential, which may be regarded as an external vector potential. The total grand potential, consisting of the tree-level potential, the zero-point contribution, and the counterterm potential, is extremized to yield a locally charge neutral, beta-equilibrated and minimum energy ground state. In some regions of parameter space we encounter the well-known problem of a complex effective potential. Where the potential is real and solutions can be obtained, the contributions from fluctuations are found to be small in comparison with tree-level contributions.Comment: 40 pages RevTeX, 3 epsf figure

Is SAX J1808.4-3658 a Strange Star ?

One of the most important questions in the study of compact objects is the nature of pulsars, including whether they are composed of $\beta$-stable nuclear matter or strange quark matter. Observations of the newly discovered millisecond X-ray pulsar \sax with the Rossi X-Ray Timing Explorer place firm constraint on the radius of the compact star. Comparing the mass - radius relation of \sax with the theoretical mass - radius relation for neutron stars and for strange stars, we find that a strange star model is more consistent with SAX J1808.4-3658, and suggest that it is a likely strange star candidate.Comment: 5 pages, Latex, 1 figure, corrected for some typo

Measurement of tau polarization in e+ e- annihilation at sqrt{s}=58 GeV

The polarization of tau leptons in the reaction e+ e- --> tau+ tau- has been measured using a e+e- collider, TRISTAN, at the center-of-mass energy of 58 GeV. From the kinematical distributions of daughter particles in tau --> e nu nu-bar, mu nu nu-bar, rho nu or pi(K) nu decays, the average polarization of tau- and its forward-backward asymmetry have been evaluated to be 0.012 +- 0.058 and 0.029 +- 0.057, respectively.Comment: 18 pages, 5 figure

Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18Rα

The oncolytic adenovirus (Ad) is currently being advanced as a promising antitumor remedy as it selectively replicates in tumor cells and can transfer and amplify therapeutic genes. Interleukin (IL)-12 induces a potent antitumor effect by promoting natural killer (NK) cell and cytotoxic T cell activities. IL-18 also augments cytotoxicity of NK cells and proliferation of T cells. This effect further enhances the function of IL-12 in a synergistic manner. Therefore, we investigated for the first time an effective cancer immunogene therapy of syngeneic tumors via intratumoral administration of oncolytic Ad co-expressing IL-12 and IL-18, RdB/IL-12/IL-18. Intratumoral administration of RdB/IL-12/IL-18 improved antitumor effects, as well as increased survival, in B16-F10 murine melanoma model. The ratio of T-helper type 1/2 cytokine as well as the levels of IL-12, IL-18, interferon-γ and granulocyte–macrophage colony-stimulating factor was markedly elevated in RdB/IL-12/IL-18-treated tumors. Mice injected with RdB/IL-12/IL-18 also showed enhanced cytotoxicity of tumor-specific immune cells. Consistent with these results, immense necrosis and infiltration of NK cells, as well as CD4+ and CD8+ T cells, were observed in RdB/IL-12/IL-18-treated tumor tissues. Importantly, tumors treated with RdB/IL-12/IL-18 showed an elevated number of T cells expressing IL-12Rβ2 or IL-18Rα. These results provide a new insight into therapeutic mechanisms of IL-12 plus IL-18 and provide a potential clinical cancer immunotherapeutic agent for improved antitumor immunity

Nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage: case report

A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterior and posterior mitral valve leaflet. Furthermore, there was a thrombus in the left auricular appendage despite sinus rhythm. These findings led to a diagnosis of suspected infectious endocarditis with subsequent multiple brain infarctions. The patient's general condition worsened and he died 13 days after admission. An autopsy was performed, and, while poorly differentiated cancer was observed in multiple organs, no primary tumor could be identified. Histological analysis showed that the masses of the mitral valve consisted mainly of fibrin without bacteria or oncocytes. This patient was therefore diagnosed with nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage

Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD

BACKGROUND: Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF). This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD. METHODS: VEGF levels in induced sputum were examined in 23 control subjects (12 non-smokers and 11 ex-smokers) and 29 patients with bronchitis-type of COPD. All bronchitis-type patients performed exercise testing with right heart catheterization. RESULTS: The mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) after exercise were markedly increased in all bronchitis-type patients. However, both parameters after exercise with breathing of oxygen was significantly lower than in those with breathing of room air. To attenuate the effect of hypoxia-induced pulmonary vasoconstriction during exercise, we used the change in mPAP or PVR during exercise with breathing of oxygen as a parameter of pulmonary vascular remodeling. Change in mPAP was significantly correlated with VEGF level in induced sputum from patients with chronic bronchitis (r = 0.73, p = 0.0001). Moreover, change in PVR was also correlated with VEGF level in those patients (r = 0.57, p = 0.003). CONCLUSION: A close correlation between magnitude of pulmonary hypertension with exercise and VEGF level in bronchitis-type patients could be observed. Therefore, these findings suggest the possibility that VEGF level in induced sputum is a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD