38 research outputs found
Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes
There is a recognized need for new treatment options for type 2 diabetes mellitus (T2DM). Recovery of glucose from the glomerular filtrate represents an important mechanism in maintaining glucose homeostasis and represents a novel target for the management of T2DM. Recovery of glucose from the glomerular filtrate is executed principally by the type 2 sodium-glucose cotransporter (SGLT2). Inhibition of SGLT2 promotes glucose excretion and normalizes glycemia in animal models. First reports of specifically designed SGLT2 inhibitors began to appear in the second half of the 1990s. Several candidate SGLT2 inhibitors are currently under development, with four in the later stages of clinical testing. The safety profile of SGLT2 inhibitors is expected to be good, as their target is a highly specific membrane transporter expressed almost exclusively within the renal tubules. One safety concern is that of glycosuria, which could predispose patients to increased urinary tract infections. So far the reported safety profile of SGLT2 inhibitors in clinical studies appears to confirm that the class is well tolerated. Where SGLT2 inhibitors will fit in the current cascade of treatments for T2DM has yet to be established. The expected favorable safety profile and insulin-independent mechanism of action appear to support their use in combination with other antidiabetic drugs. Promotion of glucose excretion introduces the opportunity to clear calories (80–90 g [300–400 calories] of glucose per day) in patients that are generally overweight, and is expected to work synergistically with weight reduction programs. Experience will most likely lead to better understanding of which patients are likely to respond best to SGLT2 inhibitors, and under what circumstances
Chelating N-Heterocyclic Carbene Alkoxide as a Supporting Ligand for Pd-II/IV C-H Bond Functionalization Catalysis
Synthesis and Evaluation of Several New (2-Chloroethyl)nitrosocarbamates as Potential Anticancer Agents
A 96-well automated method to study inhibitors of human sodium-dependent D-glucose transport
Atmospheric corrections of the cosmic ray fluxes detected by the Solar Neutron Telescope at the Summit of the Sierra Negra Volcano in Mexico
Un Telescopio de Neutrones Solares (TNS) fue instalado en la cima del volcán Sierra Negra, Pue., México (19.0º N , 97.3º W, 4580 m sobre el nivel del mar); el cual se encuentra en operación desde el 2004. En este trabajo, utilizamos los valores de la presión barométrica, de la presión dinámica, de la temperatura ambiental y de la humedad relativa obtenidos por una estación meteorológica cercana al TNS, para calcular los coeficientes de corrección atmosféricos para el flujo registrado de rayos cósmicos. Cuando los datos de rayos cósmicos están libres de las variaciones de origen atmosférico, analizamos los perfiles de tiempo observados por el TNS durante seis decrecimientos tipo Forbush seleccionados para el período 2011-2013. Los resultados obtenidos por varios canales de depósito de energía (30,60,90 MeV) son discutidos para establecer la confiabilidad del TNS para este tipo de eventos.
doi: https://doi.org/10.22201/igeof.00167169p.2018.57.4.210