65 research outputs found
The Use of Tisseel as a Sealant and for Prevention of Postoperative Adhesions in Microsurgical Operations for Fertility
MICROSURGICAL REANASTOMOSIS OF THE RABBIT OVIDUCT AND ITS FUNCTIONAL AND PATHOLOGICAL SEQUELAE
Microsurgical Reversal of the Artificially Induced Hydrosalpinx in the Rabbit—Morphological Studies
Aspects of the less traumatic surgical procedures and some adjuvant therapies in prevention of postoperative adhesions
Bone mass, biochemical markers and growth in children with chronic kidney disease: a 1-year prospective study
The memorial of Joseph Banks Esq to His Excellency Count Rolim Vice Roy and Captain General of the Estates of Brazil in answer to his Excellency's of November 18.19 November 1768.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldBoth GH and IGF-I stimulate bone growth, but the molecular mechanisms mediating their effects on the growth plate are not fully understood. We measured gene expression by microarray analysis in primary cultured human chondrocytes treated with either GH or IGF-I. One of the genes found to be up-regulated by both GH and IGF-I was that encoding cartilage oligomeric matrix protein (COMP). This protein is predominantly found in the extracellular matrix of cartilage. Mutations in the COMP gene have been associated with syndromes of short stature. To verify that COMP is regulated by GH in vivo, we measured COMP levels in serum in short children treated with GH. The study included 113 short prepubertal children (14 girls and 99 boys) with a mean (+/- sd) age of 8.84 +/- 2.76 yr, height sd score of -2.74 +/- 0.67, and IGF-I sd score of -1.21 +/- 1.07 at the start of GH administration. Serum levels of COMP were 1.58 +/- 0.28, 1.83 +/- 0.28 (P < 0.0001), 1.91 +/- 0.28 (P < 0.0001), 1.78 +/- 0.28 (P < 0.001), and 1.70 +/- 0.24 (P < 0.05) microg/ml at baseline and after 1 wk and 1, 3, and 12 months, respectively.In conclusion, we have demonstrated that COMP expression is up-regulated by both GH and IGF-I in primary cultured human chondrocytes. Furthermore, serum levels of COMP increase after the start of GH treatment in short children
Cartilage Oligomeric Matrix Protein Increases in Serum after the Start of Growth Hormone Treatment in Prepubertal Children
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