11 research outputs found
Cyclic tensile strain facilitates ossification of the cervical posterior longitudinal ligament via increased Indian hedgehog signaling
No full textAssociation between ossification of the posterior longitudinal ligament and ossification of the nuchal ligament in the cervical spine
No full textSleeping Habit and Other Life Styles in the Prime of Life and Risk for Ossification of the Posterior Longitudinal Ligament of the Spine (OPLL): a Case-cotnrol Study in Japan
No full textInvestigation of ossification in the posterior longitudinal ligament using micro-focus X-ray CT scanning and histological examination
No full textAssociation of a BMP9 Haplotype with Ossification of the Posterior Longitudinal Ligament (OPLL) in a Chinese Population
No full textRoles and mechanisms of leptin in osteogenic stimulation in cervical ossification of the posterior longitudinal ligament
No full textHormones and growth factors in the pathogenesis of spinal ligament ossification
No full textOssification of the spinal ligaments (OSL) is a pathologic condition that causes ectopic bone formation and subsequently results in various degrees of neurological deficit, but the etiology of OSL remains almost unknown. Some systemic hormones, such as 1,25-dihydroxyvitamin D, parathyroid hormone (PTH), insulin and leptin, and local growth factors, such as transforming growth factor-β (TGF-β), and bone morphogenetic protein (BMP), have been studied and are thought to be involved in the initiation and development of OSL. This review article summarizes these studies, delineates the possible mechanisms, and puts forward doubts and new questions. The related findings from studies of genes and target cells in the ligament of OSL are also discussed. Although these findings may be helpful in understanding the pathogenesis of OSL, much more research needs to be conducted in order to investigate the nature of OSL
