672 research outputs found

    The Incoherence of Success: Intersections of Marriage and Education in a Second-Chance Girls\u27 Education Initiative in Rural Upper Egypt

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    In Egypt, early-marriage is implicated as a barrier to educational access for girls living in rural areas. It is understood to impede women’s access to education and the labor market. This paper focuses on Ishraq, a second chance girls’ education initiative brought on by the Girls Education Initiative-Egypt. Using a critical poststructural conceptual framework, this paper examines how individuals associated with the Ishraq program engage in social contests concerning the relationship between marriage and education by employing a qualitative case study approach grounded in ethnographic methodological considerations. This essay argues participant’s view religious life as the single most important consideration in articulating and enacting their conceptions of community development and girl’s empowerment, providing a framework for understanding the relationship between marriage and education. These perspectives demonstrate how participants navigate certain structural realities in their lives and the strategies they employ in localizing the designed affects of the Ishraq program

    Nonuniversal Effects in the Homogeneous Bose Gas

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    Effective field theory predicts that the leading nonuniversal effects in the homogeneous Bose gas arise from the effective range for S-wave scattering and from an effective three-body contact interaction. We calculate the leading nonuniversal contributions to the energy density and condensate fraction and compare the predictions with results from diffusion Monte Carlo calculations by Giorgini, Boronat, and Casulleras. We give a crude determination of the strength of the three-body contact interaction for various model potentials. Accurate determinations could be obtained from diffusion Monte Carlo calculations of the energy density with higher statistics.Comment: 24 pages, RevTex, 5 ps figures, included with epsf.te

    Distance Education Challenges Facing Parents of Students with Reading Difficulties During the Corona Pandemic

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    Corona pandemic has caused severe disruption and challenges in all systems around the country. To overcome the prevalence of the virus, education systems switching to distance learning, and we were not prepared for that. This study examines the effect of COVID-19 on distance learning in Egypt for students with reading difficulties, parental attitudes towards distance learning, and parental competencies. In this study, 64 parents whose students have reading disabilities were surveyed. The research data was analyzed. According to the results, remote learning is one of the new teaching concepts that has negative perceptions in Egypt. More than 70% of participants think that distance learning isn’t an efficient way to teach students with reading difficulties. These were lessons learned from the pandemic that can be applied post-pandemic. In addition, the pandemic has brought to light inequalities in technology access and parental literacy and offers a chance to address these inequalities in the future. It is important to support the operation of remote learning relevant special education contexts as well as provide practical and research recommendation

    Evolutionary framework with reinforcement learning-based mutation adaptation

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    Although several multi-operator and multi-method approaches for solving optimization problems have been proposed, their performances are not consistent for a wide range of optimization problems. Also, the task of ensuring the appropriate selection of algorithms and operators may be inefficient since their designs are undertaken mainly through trial and error. This research proposes an improved optimization framework that uses the benefits of multiple algorithms, namely, a multi-operator differential evolution algorithm and a co-variance matrix adaptation evolution strategy. In the former, reinforcement learning is used to automatically choose the best differential evolution operator. To judge the performance of the proposed framework, three benchmark sets of bound-constrained optimization problems (73 problems) with 10, 30 and 50 dimensions are solved. Further, the proposed algorithm has been tested by solving optimization problems with 100 dimensions taken from CEC2014 and CEC2017 benchmark problems. A real-world application data set has also been solved. Several experiments are designed to analyze the effects of different components of the proposed framework, with the best variant compared with a number of state-of-the-art algorithms. The experimental results show that the proposed algorithm is able to outperform all the others considered.</p

    A Rare Cause of Renal Mass; A Case Study

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    A seventy five year old gentleman with the clinical diagnosis of renal tuberculosis was found to have renal squamous cell carcinoma. The clinical presentation and management are being discussed

    A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment

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    Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Posterior infectious uveitis can be caused by bacteria, virus, fungi, or protozoa. Mode of treatment varies greatly based on the infectious etiology. Certain drugs have advantages over others in the treatment of infectious uveitis. Topical and systemic therapies are often employed in the treatment of ocular infection, yet the route of treatment can have limitations based on penetration, concentration, and duration. The introduction of intravitreal antimicrobial therapy has advanced the management of intraocular infections. Being able to bypass blood-ocular barriers allows high drug concentrations to be delivered directly to the posterior segment with minimal systemic absorption. However, because the difference between the therapeutic and the toxic doses of some antimicrobial drugs falls within a narrow concentration range, intravitreal therapy could be associated with ocular toxicity risks.  In many cases of infectious uveitis, combination of intravitreal and systemic therapies are necessary. In this comprehensive review, the authors aimed at reviewing clinically relevant data regarding intraocular and systemic antimicrobial therapy for posterior segment infectious uveitis. The review also discussed the evolving trends in intraocular treatment, and elaborated on antibiotic pharmacokinetics and pharmacodynamics, efficacy, and adverse effects

    A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment

    Get PDF
    Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Posterior infectious uveitis can be caused by bacteria, virus, fungi, or protozoa. Mode of treatment varies greatly based on the infectious etiology. Certain drugs have advantages over others in the treatment of infectious uveitis. Topical and systemic therapies are often employed in the treatment of ocular infection, yet the route of treatment can have limitations based on penetration, concentration, and duration. The introduction of intravitreal antimicrobial therapy has advanced the management of intraocular infections. Being able to bypass blood-ocular barriers allows high drug concentrations to be delivered directly to the posterior segment with minimal systemic absorption. However, because the difference between the therapeutic and the toxic doses of some antimicrobial drugs falls within a narrow concentration range, intravitreal therapy could be associated with ocular toxicity risks.  In many cases of infectious uveitis, combination of intravitreal and systemic therapies are necessary. In this comprehensive review, the authors aimed at reviewing clinically relevant data regarding intraocular and systemic antimicrobial therapy for posterior segment infectious uveitis. The review also discussed the evolving trends in intraocular treatment, and elaborated on antibiotic pharmacokinetics and pharmacodynamics, efficacy, and adverse effects

    MOLECULAR CHARACTERIZATION OF TUMOR NECROSIS FACTOR- Α (TNFΑ) GENE IN EGYPTIAN RIVER BUFFALOES

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    Tumor Necrosis Factor-α (TNFα) is a cytokine signaling protein which has an important role in the immune system regulation and affect female reproductive performance. The objective of this study was investigation the TNFα gene polymorphism and its potential effects in female buffaloes fertility. The DNA was extracted from the blood of 81 buffalo females and a 592 bp fragment contains the full coding region of TNFα-exon 4 was amplified by PCR which subsequently treated with RsaI restriction enzyme. The PCR-RFLP pattern showed that all the animals had fixed CC genotype and T allele was not detected. Sequencing of amplified fragment (GenBank accession No. KY885010) flowed by sequence alignment with GenBank database revealed that the river buffalo target sequence was homologues to cattle than goat, sheep, human and mouse on DNA and amino acids levels. Comparison of TNFα amplicon with homologues Bubalus bubalis records in the GenBank detected 3 SNPs in exon 4. Two of these SNPs were synonymous while the third located in the 3` UTR. Different effects of some of discovered SNPs on RNA cis-regulatory elements and hn mRNA and mature mRNA secondary structures were predicted

    Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds

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    : Understanding the genomic features of livestock is essential for successful breeding programs and conservation. This information is scarce for local goat breeds in Egypt. In the current study, genomic regions with selection signatures were identified as well as runs of homozygosity (ROH), genomic inbreeding coefficients (FROH) and fixation index (FST) were detected in Egyptian Nubian, Damascus, Barki and Boer goat breeds. A total of 46,268 SNP markers and 337 animals were available for the genomic analyses. On average, 145.44, 42.02, 87.90 and 126.95 ROHs were detected per individual in the autosomal genome of the respective breeds. The mean accumulative ROH lengths ranged from 46.5&nbsp;Mb in Damascus to 360&nbsp;Mb in Egyptian Nubian. The short ROH segments (&lt; 2&nbsp;Mb) were most frequent in all breeds, while the longest ROH segments (&gt; 16&nbsp;Mb) were exclusively found in the Egyptian Nubian. The highest average FROH was observed in Egyptian Nubian (~ 0.12) followed by Boer (~ 0.11), while the lowest FROH was found in Damascus (~ 0.05) and Barki breed (~ 0.03). The estimated mean FST was 0.14 (Egyptian Nubian and Boer), 0.077 (Egyptian Nubian and Barki), 0.075 (Egyptian Nubian and Damascus), 0.071 (Barki and Boer), 0.064 (Damascus and Boer), and 0.015 (Damascus and Barki), for each pair of breeds. Interestingly, multiple SNPs that accounted for high FST values were observed on chromosome 6 in regions harboring ALPK1 and KCNIP4. Genomic regions overlapping both FST and ROH harbor genes related to immunity (IL4R, PHF23, GABARAP, GPS2, and CD68), reproduction (SPATA2L, TNFSF12, TMEM95, and RNF17), embryonic development (TCF25 and SOX15) and adaptation (MC1R, KDR, and KIT), suggesting potential genetic adaptations to local environmental conditions. Our results contribute to the understanding of the genetic architecture of different goat breeds and may provide valuable information for effective preservation and breeding programs of local goat breeds in Egypt
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