An Overdensity of Lyman-alpha Emitters at Redshift z=5.7 near the Hubble Ultra Deep Field

We have identified an obvious and strong large scale structure at redshift z=5.75 in a wide (31 by 33 arcminute) field, narrowband survey of the Chandra Deep Field South region. This structure is traced by 17 candidate Lyman alpha emitters, among which 12 are found in an 823nm filter (corresponding to Lyman alpha at z=5.77 +- 0.03) and 5 in an 815nm image (z=5.70 +- 0.03). The Lyman alpha emitters in both redshift bins are concentrated in one quadrant of the field. The Hubble Ultra Deep Field, Chandra Deep Field South, and GOODS-South fields all lie near the edge of this overdense region. Our results are consistent with reports of an overdensity in the UDF region at z=5.9. This structure is the highest redshift overdensity found so far.Comment: 12 pages, AASTeX. Submitted to ApJ Letters, and revised in response to referee's comment

Advantages of Looping at the Elementary Level

Advantages of Looping at the Elementary Level Recently, looping has been getting attention from educators and educational reformers as a low cost, easily implemented way to improve education. In this project, the author created an inservice presentation designed as an introduction to the practice of looping at the elementary level. The target audience was elementary teachers and administrators. The presentation provided a brief history of the practice of looping, the theory behind the practice, a synthesis of the benefits and possible challenges of looping, and finally, several tips and considerations for the implementation of looping

CHARACTERIZATION OF SPONTANEOUS HYPERTENSION IN CHLOROCEBUS AETHIOPS SABAEUS, THE AFRICAN GREEN MONKEY

Hypertension is a complex multifactorial pathology that is a major risk factor for the development of cardiovascular disease, stroke, and end stage renal disease. In the United States, hypertension affects over 1 in 3 adults and comprises an annual cost of over $58 billion in the healthcare industry. While remarkable strides in the diagnosis and treatment of hypertension have been made since the pathology was first treated in the 1960s, a remarkable 13% of patients with elevated blood pressures are classified as resistant hypertensive, where blood pressure remains uncontrolled while on three or more classes of anti-hypertensive drugs. This treatment gap suggests that researchers need to develop and utilize translational models that recapitulate the pathologies seen in patient populations. Non-human primates (NHP) are highly similar to humans in terms of physiology, circadian rhythmicity, behavior, and gene sequence and structure. Development of NHP models that spontaneously develop pathologies, like spontaneous hypertension, provide novel and vital tools to studying disease. Overall, this dissertation is a comparative analysis of the mechanisms that drive the development of spontaneous hypertension in Chlorocebus aethiops sabaeus, an Old World non-human primate, and known mediators of essential hypertension in human populations. Chapter 2 presents how hypertensive (HT) African Green Monkeys (AGMs) are older, with elevated heart rates, increased renal vascular wall/lumen ratios, and altered glomerular morphologies compared to normotensive (NT) controls. Chapter 3 describes metabolic studies performed in a large cohort of animals that identified elevated proteinuria and ion excretion in HT AGMs compared to NT animals. Chapter 4 focuses on the contribution of sympathetic nervous system to the development of hypertension in this animal model and describes the significant left ventricular hypertrophy and elevation of adrenergic receptor mRNA in HT AGMs. Chapter 5 examines how age affects hypertension and renal function in the NT and HT AGMs. Together these data provide a foundational basis for the development of spontaneous hypertension in the AGM and provide a novel translational model for the study of cardiovascular disease

Luminosity functions of Lyman-alpha emitters at z=6.5, and z=5.7: evidence against reionization at z=6

Lyman-alpha emission from galaxies should be suppressed completely or partially at redshifts beyond reionization. Without knowing the instrinsic properties of galaxies at z = 6.5, this attenuation is hard to infer in any one source, but can be infered from a comparison of luminosity functions of lyman-alpha emitters at redshifts just before and after reionization. We combine published surveys of widely varying depths and areas to construct luminosity functions at z=6.5 and 5.7, where the characteristic luminosity L_star and density phi_star are well constrained while the faint-end slope of the luminosity function is essentially unconstrained. Excellent consistency is seen in all but one published result. We then calculate the likelihood of obtaining the z=6.5 observations given the z=5.7 luminosity function with (A) no evolution and (B) an attenuation of a factor of three. Hypothesis (A) gives an acceptable likelihood while (B) does not. This indicates that the z=6.5 lyman-alpha lines are not strongly suppressed by a neutral intergalactic medium and that reionization was largely complete at z = 6.5.Comment: Submitted to Astrophysical Journal Letter

Starting a Private Foundation: Carrying Out the Donor's Intent

A beginners guide to setting up a private foundation, this report is designed to provide the reader with a general insight into the world of philanthropy and specific observations about private foundations. Topics covered include: charitable giving in general, defining and carrying out your mission, determining the structure of your foundation and how to begin the foundation. Full content listing is provided

Our Parents, Ourselves: Health Care for an Aging Population; A Report of the Dartmouth Atlas Project

The new Dartmouth Atlas, funded by The John A. Hartford Foundation, is a report card that analyzes Medicare data to show us where the United States is making progress in patient-centered, evidence-based care for Medicare beneficiaries and where improvement is still needed. It also offers insight into regional variations in care.Filling in the gaps in our knowledge about the state of care across the country will help health care providers, health systems, and patients and families work together to improve care for all older adults.This Dartmouth Atlas report looks at a number of measures from Medicare data, including:The number of days older adults spend in contact with the health care system;Use of high-risk medications;Cancer screening rates (and how they compare with recommendations);30-day hospital readmission rates;Annual Wellness Visit (AWV) rates;Late hospice referral; andThe number of days spent in intensive care.The report also offers a historical look at key practices, comparing data from 2003-05 and 2012

Classic Article: The influence of deposit-feeding organisms on sediment stability and community trophic structure

Deposit-feeding and suspension-feeding benthos in Buzzards Bay, Massachusetts, show marked spatial separation; suspension feeders are largely confined to sandy or firm mud bottoms while deposit feeders attain high densities on soft muddy substrata. Food source and bottom stability have been investigated as potential factors effecting this trophic-group separation. Between October 4, 1967 and August 22, 1969, observations were made at 11 stations in Buzzards Bay, Massachusetts, along two widely separated transects over bottoms ranging in texture from silt to fine and medium sand. Water depths at these stations ranged from 3 m to 20 m. Scuba divers made many of the field observations and collected most of the samples. This study included sampling of benthic macrofauna, taking bottom photographs, analyzing sedimentary structures, texture, organic content and water content of the sediments, and measuring both water currents and suspended sediment above the bottom. Laboratory experiments were also carried out to determine differential resuspension between burrowed and unburrowed muds. Intensive reworking of the upper few centimeters of a mud bottom by deposit feeders produces a fluid fecal-rich surface that is easily resuspended by low-velocity tidal currents. We suggest that the physical instability of this fecal surface tends to: (i) clog the filtering structures of suspension-feeding organisms, (ii) bury newly settled larvae or discourage the settling of suspension-feeding larvae, and (iii) prevent sessile epifauna from attaching to an unstable mud bottom. Thus suspension feeders are unable to successfully populate all areas of the bottom where a suspended food source is available, especially in areas where mud bottoms are intensively reworked by deposit feeders. Modification of the benthic environment by deposit feeders, resulting in the exclusion of many suspension feeders and sessile epifauna, is an example of trophic group amensalism. This biotic relationship appears to be important in shaping trophic-group distributions in embayments and basins on continental shelves

Brief Cognitive Screening Tools for Primary Care Practice

Early detection and diagnosis of Alzheimer’s disease and other cognitive impairment presents as a critical issue facing primary and specialty care providers in Washington State. In order to address the gaps and challenges faced by providers, the Dementia Action Collaborative offers the current paper to provide information and guidance around early detection and diagnosis of memory loss and dementia, including Alzheimer’s disease. At the conclusion of this paper, providers should be able to identify indications and opportunities for detection, appropriate tools, and care pathways for individuals and families affected by cognitive impairment and dementia