EPMR is a practical option to cure colorectal tumors

The definitive version is available at www.blackwell-synergy.com AuthorEndoscopic mucosal resection (EMR) and endoscopic piecemeal resection (EPMR) are therapeutic options widely accepted for the treatment of colon adenoma, intramucosal cancer and minimally invasive submucosal cancer. Our retrospective investigation revealed that single EMR or EPMR with 2-channel procedure cured 913 (96.6%) of 945 flat and depressed tumors, verifying the significant role of certain procedures in the therapeutic strategy for colorectal neoplasm. Predicting the invasion depth and fibrotic change before resection are proposed to be necessary for improving complete resection rate of first EMR or EPMR. Hood, 2-channel method and the combination of EMR and circumferential mucosal incision are regarded to be practical procedures on EPMR

Auto-Fluorescence Imaging is useful to assess the activity of ulcerative colitis

The definitive version is available at www.blackwell-synergy.com authorThe efficacy of AFI for assessing UC activity was reviewed. AFI images of UC lesions could be classified into 4 categories; Green, Green with Purple Spots, Purple with Green Spots, Purple. The strength of purple in AFI images of UC lesions is related to histologic severity, thus this classification is helpful to assess the activity of UC. We also quantified the auto-fluorescence of AFI images using color analysis software. Active lesions showed significantly low auto-florescence / reflex ration rather than inactive area in UC patients. The ratio is inversely proportional to histologic severity. When defining the cut-off value as 0.9, the accuracy to predict histologic activity by AFI is 92%

Auto-Fluorescence Imaging is useful to assess the activity of ulcerative colitis

http://dx.doi.org/10.1111/j.1443-1661.2007.00725.x | http://dx.doi.org/10.1111/j.1443-1661.2007.00725.

Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion

Elsevier, Tanabe, Hiroki ; Ayabe, Tokiyoshi ; Maemoto, Atsuo ; Ishikawa, Chisato ; Inaba, Yuhei ; Sato, Ryu ; Moriichi, Kentaro ; Okamoto, Kotaro ; Watari, Jiro ; Kono, Toru ; Ashida, Toshifumi ; Kohgo, Yutaka, Biochemical and Biophysical Research Communications, 358(1), 2007, 349-335. authorα-Defensin is an antimicrobial peptide which plays an important role in innate immunity. Human defensin (HD)-5 is stored in the Paneth cells of the small intestine as a pro-form and is cleaved by trypsin, which is co-secreted from the Paneth cell granules. The mature HD-5 is protected from further digestion by the proteolysis enzyme. We generated both recombinant HD-5 and proHD-5, and the reduced form of each peptide in order to determine their physiological roles of the disulfide bonds. The reduced proHD-5 attenuated the bactericidal activity and the stability against the trypsin digestion. Human defensin was protected from the enzymatic degradation by disulfide bridges. We further purified the HD-5 with a disulfide variation in the small intestine of Crohn’s disease patients. The HD-5 was sensitive to the trypsin treatment. These observations evidently predict that a defensin deficiency may be caused by a disulfide disorder in the disease

Endoscopic piecemeal resection is a practical option to cure colorectal tumors

http://dx.doi.org/10.1111/j.1443-1661.2009.00861.x | http://dx.doi.org/10.1111/j.1443-1661.2009.00861.