Spin-Down of the Long-Period Accreting Pulsar 4U 2206+54

4U 2206+54 is a high mass X-ray binary which has been suspected to contain a neutron star accreting from the wind of its companion BD +53 2790. Reig et al. have recently detected 5560 s period pulsations in both RXTE and INTEGRAL observations which they conclude are due to the spin of the neutron star. We present observations made with Suzaku which are contemporaneous with their RXTE observation of this source. We find strong pulsations at a period of 5554 +/- 9 s in agreement with their results. We also present a reanalysis of BeppoSAX observations of 4U 2206+54 made in 1998, in which we find strong pulsations at a period of 5420 +/- 28 seconds, revealing a spin-down trend in this long-period accreting pulsar. Analysis of these data suggests that the neutron star in this system is an accretion-powered magnetar.Comment: Submitted to The Astrophysical Journa

Anatomical, histomorphological, and molecular classification of cholangiocarcinoma

Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin-producing adenocarcinomas or papillary tumours; intrahepatic cholangiocarcinomas are more heterogeneous and can be sub-classified according to the level or size of the displayed bile duct. Cholangiocarcinoma develops through multistep carcinogenesis and is preceded by dysplastic and in situ lesions. Definition and clinical significance of precursor lesions, including biliary intraepithelial neoplasia, intraductal papillary neoplasms of the bile duct, intraductal tubulopapillary neoplasms and mucinous cystic neoplasm, are discussed in this review. A main challenge in diagnosing cholangiocarcinoma is the fact that tumour tissue for histological examination is difficult to obtain. Thus, a major clinical obstacle is the establishment of the correct diagnosis at a tumour stage that is amenable to surgery which still represents the only curable therapeutic option. Current standards, methodology and criteria for diagnosis are discussed. Cholangiocarcinoma represents a heterogeneous tumour with regard to molecular alterations. In intrahepatic subtype, mainly two distinctive morpho-molecular groups can currently be discriminated. Large-duct type intrahepatic cholangiocarcinoma shows a high mutation frequency of oncogenes and tumour suppressor genes, such as KRAS and TP53 while Isocitrate Dehydrogenase 1/2 mutations and Fibroblast Growth Factor Receptor 2-fusions are typically seen in small-duct type tumours. It is most important to ensure the separation of the given anatomical subtypes and to search for distinct subgroups within the subtypes on a molecular and morphological basis

New Public-key Cryptosystem Using Braid Groups

Abstract. The braid groups are infinite non-commutative groups naturally arising from geometric braids. The aim of this article is twofold. One is to show that the braid groups can serve as a good source to enrich cryptography. The feature that makes the braid groups useful to cryptography includes the followings: (i) The word problem is solved via a fast algorithm which computes the canonical form which can be efficiently manipulated by computers. (ii) The group operations can be performed efficiently. (iii) The braid groups have many mathematically hard problems that can be utilized to design cryptographic primitives. The other is to propose and implement a new key agreement scheme and public key cryptosystem based on these primitives in the braid groups. The efficiency of our systems is demonstrated by their speed and information rate. The security of our systems is based on topological, combinatorial and group-theoretical problems that are intractible according to our current mathematical knowledge. The foundation of our systems is quite different from widely used cryptosystems based on number theory, but there are some similarities in design. Key words: public key cryptosystem, braid group, conjugacy problem, key exchange, hard problem, non-commutative group, one-way function, public key infrastructure