10 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells
- Author
- A Gomes
- A Ludke
- A Perl
- AC Ribou
- Adam Gbankoto
- AF Branco
- Amandine Bijoux
- Anne-Cécile Ribou
- AR Imondi
- B Kalyanaraman
- B Zhao
- BB Hasinoff
- BB Hasinoff
- Christophe Canal
- CJ Zeiss
- D Lebrecht
- Daniela Panáková
- DS Alberts
- E Martin
- EH Choi
- EL Bell
- F Antunes
- F Antunes
- F Bernuzzi
- F Galetta
- F Yang
- G Bartosz
- G Corna
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- H Ito
- H Kaiserová
- H Sakahira
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- J Gao
- J Grossmann
- J Kluza
- J Ma
- J Savatier
- JJ Lemasters
- K Jung
- LD Horwitz
- M Gilleron
- M Gülden
- M Napirei
- M Tokarska-Schlattner
- M Štěrba
- MJ Arends
- N Zamzami
- NJ McCarthy
- P Hašková
- P Spallarossa
- PE Schroeder
- PR Shan
- PS Green
- R Lai
- S Classen
- S Deng
- S Elmore
- S Toné
- S Zhou
- SE Lipshultz
- SL Pereira
- SM Cutts
- T Hirsch
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- T Rharass
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- TV Dudnakova
- X Tan
- Y Moné
- Y Octavia
- Y Pommier
- YL Lyu
- Z Junjing
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synthesis and Cytotoxic and Antiviral Activity Profiling of All‐Four Isomeric Series of Pyrido‐Fused 7‐Deazapurine Ribonucleosides
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- Anzai K.
- Barbora Lišková
- Blanka Klepetářová
- Cho J. H.
- Eva Tloušťová
- Ghosh K.
- Helena Mertlíková‐Kaiserová
- Jana Trylčová
- Lee J.-H.
- Loomis C. R.
- Lucia Veselovská
- Marián Hajdúch
- Martina Medvedíková
- Michal Hocek
- Michal Tichý
- Natálie Kudlová
- Nemanja Milisavljevic
- Nishimura H.
- Nosková V.
- Ondřej Hodek
- Pavla Perlíková
- Petr Džubák
- Radek Pohl
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- Scudiero D. A.
- Soňa Gurská
- Publication venue
- 'Wiley'
- Publication date
- Field of study
4′-Epidoxorubicin To Re-explore Anthracycline Degradation in Cardiomyocytes
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- Altan N.
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- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative
- Author
- A Minaei
- A Pham
- AW Tolcher
- B Ríhová
- BN Zordoky
- CF Thorn
- D Agudelo
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- DL Gustafson
- F Qian
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- FY Chen
- G Wang
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- H Kaiserová
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- SW Kennedy
- Y He
- Y Issan
- Y Liu
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- YL Chen
- ZH Maayah
- ZH Maayah
- ZH Maayah
- ZH Maayah
- ZH Maayah
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sugar Cane and Sugar Beet Molasses, Antioxidant-rich Alternatives to Refined Sugar
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- Aires A.
- Alessandra Bordoni
- Ana María Gómez-Caravaca
- Azzi A.
- Baek B. S.
- Balasundram N.
- Bradford M. M.
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- Maria Fiorenza Caboni
- Mattia Di Nunzio
- Mersch-Sundermann V.
- Moure A.
- Orhan D. D.
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- Phillips K. M.
- Pietta P. G.
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- Vercellotti J. R.
- Veronica Valli
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- Yadav D. V.
- Yao L. H.
- Yilmaz Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Naringenin Enhances the Anti-Tumor Effect of Doxorubicin Through Selectively Inhibiting the Activity of Multidrug Resistance-Associated Proteins but not P-glycoprotein
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- A. Bast
- A. T. Nies
- C. Calatozzolo
- C. Kimchi-Sarfaty
- C. L. Hammond
- C. M. Laurençot
- C. Zanini
- Chun Ling Zhang
- E. H. Rubin
- E. K. Rowinsky
- E. Teodori
- F. Tosetti
- Fa Yun Zhang
- G. A. Thomas
- Gang Jun Du
- H. Kaiserová
- H. M. Arafa
- H. Minderman
- J. J. Zanden van
- L. A. Doyle
- L. Beketic-Oreskovic
- L. C. Young
- L. Gandhi
- Ling Zhang
- M. Biscardi
- M. Bredel
- M. Hadjeri
- M. M. Gottesman
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- P. Borst
- P. Mitra
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- R. V. Kondratov
- S. Kitagawa
- S. Kitagawa
- S. P. Cole
- S. Zhang
- S. Zhang
- S. Zhang
- T. Abe
- T. Mosmann
- V. Jekerle
- V. Stierlé
- Wan Liang Lu
- Wei Liang
- X. F. Hu
- Y. Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach
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- A Abbaszadeh
- A Baghaei
- A Ghasemi Tousi
- A Jafari
- A Karimani
- A Korkmaz
- A Maleki
- A Mathai
- A Pannu
- AA Vosooghi
- AH Abdolghaffari
- AM Sciuto
- AS Gouda
- AT Proudfoot
- Azin Samimi
- B Hashemi-Domeneh
- B Lakshmi
- B Mohan
- B Mostafazadeh
- C Marchetti
- D Gunnell
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- F Taghaddosinejad
- GJ Daglish
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- H Haghi-Aminjan
- H Hassanian-Moghaddam
- H Kaiserová
- H Kariman
- H Mohammadi
- H Shafiee
- H Yan
- HH Aminjan
- I Mozos
- J Chui
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- JD Barry
- K Soltaninejad
- K Soltaninejad
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- L Paulis
- M Baeeri
- M Goharbari
- M Lescan
- M Martin
- Mahmood Maniati
- MD Cappellini
- Mehdi Forouzesh
- MH Asghari
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- ML Circu
- Mohsen Maleknia
- N Li
- N Valmas
- NS Nath
- O Mehrpour
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- P Ježek
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- Samira Valiyari
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- SM Marashi
- SS Lee
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- V Kuhn
- V Srinivasan
- W Elabbassi
- Z Hena
- Z Oghabian
- Z-Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Heart As a Target for Xenobiotic Toxicity: The Cardiac Susceptibility to Oxidative Stress
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- Altug S.
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- 'American Chemical Society (ACS)'
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- Field of study
Copper signalling: causes and consequences
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- A Barilli
- A Baslé
- A Bhattacharjee
- A Chakraborty
- A Fernandes
- A Gaál
- A Gupta
- A Gupta
- A Gupte
- A Gupte
- A Hopt
- A Itoh
- A Küffer
- A Lubin
- A Mathie
- A Pal
- A Pal
- A Pal
- A Palló
- A Pasquarello
- A Piriou
- A Pompella
- A Shcheglovitov
- A Shimada
- A Sinopoli
- A Verkhratsky
- AA Alghobashy
- AI Bush
- AI Bush
- AK Boal
- AL Lamb
- AN Pham
- AS Sansinanea
- AT Aron
- B Bánsági
- B Desforges
- B Sullivan
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- B-S Choi
- BJ McCranor
- BM Paterson
- BR Lins
- C Angelé-Martínez
- C Duncan
- C Hureau
- C Marchetti
- C Maureira
- C Santini
- C-F Yen
- C-G Li
- CC Moser
- CC Page
- CD Fan
- CJ Chang
- CJ De Feo
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CL Haigh
- CM Ackerman
- CM Ackerman
- CM Carver
- CM Opazo
- CM Weekley
- CPW Soon
- CR Andrew
- CR Liao
- D Chen
- D Giustarini
- D Kahra
- D Kumar
- D Ramos
- DA Armstrong
- DA Quist
- DE Hartter
- DE Hartter
- DE Sutherland
- DJ Cash
- DJ Cash
- DJ Hare
- DM Lovinger
- DM Mann
- DR Brown
- E Bonilla
- E Bárány
- E Delhaize
- E Kumamoto
- E Ladomersky
- E Løvaas
- E Pan
- E Scherzinger
- EB Maryon
- ED Gaier
- EH Gray
- EI Hamilton
- EI Solomon
- EI Solomon
- EJ Margalioth
- EM Johnston
- EM Johnston
- EM Shepard
- EN Mentz
- EW Ainscough
- F Bisceglie
- F Bulcke
- F Bulcke
- F Durola
- F Neumaier
- F Steinberg
- F Wang
- F Xie
- FQ Schafer
- G Caruso
- G Giachin
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- GD Shimberg
- GI Giles
- GJ Brewer
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- H Sakurai
- H Yoshiji
- HF Stanyon
- HJ Kim
- HJ Stuerenburg
- HS Comstra
- I Horvath
- IF Scheiber
- IF Scheiber
- IS Villumsen
- István Jablonkai
- J Benedikt
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- J Sneddon
- J Telianidis
- J Witherick
- J-P Collin
- JA Cotruvo Jr
- JA Lyons
- JB Hilton
- JC Biancotti
- JD Watson
- JE Raftos
- JH Freedman
- JH Viles
- JL Fisher
- JM Argüello
- JN Cobley
- JN Cumings
- JR Kirshner
- Julianna Kardos
- JY Ma
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- Katalin Jemnitz
- KF Adams
- KG Daniel
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- KM Davies
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- KM Davies
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- L Banci
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- M Toni
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- MA Greenough
- MA Halcrow
- MC Linder
- ME Aliaga
- MG Novelle
- MI Ivanova
- Michal S. Shoshan
- MJ Ceko
- ML Schlief
- ML Schlief
- ML Schlief
- MM Cortese-Krott
- MS Niemiec
- MT Morgan
- MY Khodanovich
- N Benseny-Cases
- N D’Ambrosi
- N Liu
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- N Sowada
- NC Nayak
- NE Wezynfeld
- NH Vo
- O Bandmann
- O Kékesi
- P Bagchi
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- P Ács
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- PG Georgopoulos
- PV Chang
- Q Jin
- R Cao
- R Delgado
- R Dringen
- R Furman
- R Kovács
- R Kovács
- R Kovács
- R Kumar
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- R Srivastava
- R van de Bospoort
- RA Bissell
- RA Scott
- RDM Travasso
- Richard Kovács
- Richard W. Strange
- RR Crichton
- RT Thomason
- RW Colburn
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- SA James
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- SC Dodani
- SC Dodani
- SC Drew
- SG Kaler
- SG Kaler
- SJ Haswell
- SN Skatchkov
- SS Stojilkovic
- SV Smith
- SY Assaf
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- T Lech
- T Lőrincz
- T Narahashi
- T Nevitt
- T Schumann
- T Skripuletz
- TA Nichols
- TC Jorgenson
- TD Rae
- TJ Lawton
- TJ van’t Erve
- TP McGee
- TR Young
- TS Sun
- V Gudi
- V Lanza
- V Tõugu
- VFS Pape
- VP Kotsaki-Kovatsi
- W Bal
- W Cypryk
- W Keown
- W Neumann
- W Small Jr
- W Wang
- W Zhou
- W-J Lian
- WD Jiang
- WH Koppenol
- WIM Vonk
- WW Harrison
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- X Liu
- X-M Wu
- XM Xie
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- Y Furukawa
- Y Hatori
- Y Hatori
- Y Hatori
- Y Hatori
- Y Li
- Y Li
- Y Lu
- Y Ogra
- Y Ogra
- Y Okita
- Y Seo
- Y Wang
- Y Xie
- Y Yoo
- Y Zou
- Y-H Han
- YJ Kang
- Z Szabó*
- Z Xiao
- ZM Ma
- Ágnes Simon
- É Szárics
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study