Immunocytochemical localisation of follicle stimulating hormone (FSH) in normal, benign and malignant human prostates.

Immunocytochemical localisation of follicle stimulating hormone (FSH) was carried out in normal, benign and malignant human prostates by indirect immunoperoxidase technique. Positive staining was observed in the epithelial cells of all the three categories, while the stromal cells showed a weakly positive reaction in a few specimens. The brown reaction product was dispersed in the cytoplasm of the epithelial cells. These observations demonstrate the presence of immunoreactive FSH-like peptide in human prostate. The significance of FSH in the aetiopathology of prostatic disorders is discussed

Studies on immunoneutralization of inhibin: a time course study

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Lack of seasonal changes in biochemical constituents of Bonnet monkey semen

The seasonal changes in the production of semen were investigated in four proven-fertile bonnet males (Macaca radiata), maintained under ordinary laboratory conditions. The various physical and biochemical characteristics of 190 ejaculates collected at different seasons of the year were analyzed. There were no significant changes in the responses to penile stimulation, in semen volume, sperm density, and in the concentrations of fructose, citric acid, sialic acid, maltase, amylase, and protein of seminal plasma, attributable to season

Androgenic control of the secretion of accessory reproductive organs of Maccaca radiata

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Enhancement of in vitro release of FSH from rat pituitaries by a synthetic nonapeptide fragment of human seminal plasma inhibin

A synthetic C-terminal nonapeptide fragment of human seminal plasma inhibin preferentially enhances the basal release of FSH from rat pituitaries incubated in vitro, which indicates a direct action of the peptide on the pituitary. However, in the presence of LHRH, both FSH and LH release was increased particularly at higher doses of the nonapeptide. There was no change in prolactin release at 5 and 50 ng/ml but prolactin release was suppressed significantly at 500 ng/ml

Involvement of prostate in the regulation of serum levels of FSH, LH, and prolactin in male rats

Circulatory levels of LH and FSH were measured in serum of male rats (28, 35, 42, 63, 70, 77, and 207 days of age) 7 days following sham operation, castration (C), prostatectomy (P), and castration + prostatectomy (C + P). In C + P rats that were 49, 63, 70, 77, and 207 days of age, the plasma FSH was significantly elevated as compared to the C group. Administration of aqueous prostatic extract restored the circulatory FSH level in C + P animals to that observed in C animals, whereas in C animals FSH levels were suppressed, indicating inhibinlike activity. In rats 49 and 77 days of age, circulatory LH levels were significantly suppressed in C + P animals as compared to the C group. Both castration and prostatectomy alone suppressed circulatory prolactin levels. Administration of prostatic extract to castrated animals restored the prolactin levels to that of the sham-operated control animals. Results of the present study suggest a role of the prostate in feedback regulation of FSH and prolactin

Circulating levels of inhibin in cancer

Study on frequency distribution of serum inhibin levels - a peptide hormone involved in suppression of follicle stimulating hormone - was carried out using a specific radioimmunoassay developed in this laboratory, on 237 sera from normal men and women, from male and female patients with cancer prostate, lung, stomach and breast, and from patients with non-malignant disease of the respective organ. The mean serum inhibin levels in patients with malignant and non-malignant disease of prostate (90 ± 19 ng/ml and 54 ± 8 ng/ml) were significantly higher than found in normal men (31 ± 9 ng/ml). However, the levels in cancer of stomach (70 ± 9 ng/ml) and lung (45 ± ng/ml) were higher than those in normal as well as benign condition of stomach and lung. The mean serum inhibin in case of women with cancer of breast (27 ± 5 ng/ml) and lung (53 ±16 ng/ml) were significantly higher than those found in normal women (15 ± 2 ng/ml) and in women with benign disease of breast (10 ± 3 ng/ml) and lung (21 ± 4 ng/ml). Considering the levels in individual patient basis, 66% of the patients with cancer of stomach had higher inhibin concentration than the uppermost limit of inhibin found in normal men and in contrast none in benign disease of stomach

Prostate - a novel target for evaluation of FSH modulating peptides

Effects of prostatic inhibin peptide and its synthetic fragments on FSH biosynthesis by the human pituitary and prostate, were examined in vitro. The results showed that FSH biosynthesis by prostatic tissue is modulated by these peptides in a similar fashion to that observed at the pituitary level