A relativistic coupled-channel formalism for the pion form factor

The electromagnetic form factor of a confined quark-antiquark pair is calculated within the framework of point-form relativistic quantum mechanics. The dynamics of theexchanged photon is explicitly taken into account by treating theelectromagnetic scattering of an electron by a meson as a relativistic two-channel problem for a Bakamjian-Thomas type mass operator. This approach guarantees Poincare invariance. Using a Feshbach reduction the coupled-channel problem can be converted into a one-channel problem for the elastic electron-meson channel. By comparing the one-photon-exchange optical potential at the constituent and hadronic levels, we are able to unambiguously identify the electromagnetic meson form factor. Violations of cluster-separability properties, which are inherent in the Bakamjian-Thomas approach, become negligible for sufficiently large invariant mass of the electron-meson system. In the limit of an infinitely large invariant mass, an equivalence with form-factor calculations done in front-form relativistic quantum mechanics is established analytically.Comment: 3 pages, 1 figure, submitted to EPJ Web of Conference

Point-form quantum field theory and meson form factors

We shortly review point-form quantum field theory, i.e. the canonical quantization of a relativistic field theory on a Lorentz-invariant surface of the form $x_\mu x^\mu = \tau^2$. As an example of how point-form quantum field theory may enter the framework of relativistic quantum mechanics we discuss the calculation of the electromagnetic form factor of a confined quark-antiquark pair (e.g. the pion).Comment: 3 pages, 2 figures. Based on a talk presented by W. Schweiger at the 20th European Conference on Few-Body Problems in Physics, September 10-14 2007, Pisa, Ital

Determination of the Chromaticity of the TI 8 Transfer Line Based on Kick Response Measurements

The 3 km long TI 8 transfer line is used to transfer 450 GeV proton and ion beams from the SPS to LHC collider. As part of a detailed optics investigation program the chromaticity of the transfer line was measured. Kick response data of the transfer line was recorded for various extraction energy offsets in the SPS. The quadrupolar and sextupolar field errors (b2 and b3, respectively) over the whole transfer line dipoles, a systematic error of the main quadrupole strengths and the initial momentum error were estimated by a fit. Using the updated model, the chromaticity of the line was then calculated

Trim Magnet Polarities, Dispersion, and Response Data in Sector 23

During the first LHC injection test, on 10 August 2008, the horizontal dispersion measured with beam 1 at the end of Sector 23 differed from the model prediction close to point 3. Beam-based polarity checks performed during the same period indicated an inversion of the trim quadrupole QTL11.R2. Combined with other evidence, like electrical drawings and earlier Hall-probe measurements of warm magnets, this gave rise to the hypothesis of a systematic error. Indeed a model inversion of all trim quadrupoles (QT or QTL) attached to a defocusing main quadrupole (actually the odd-numbered trim quadrupoles in Sector 23) reproduced the dispersion measurement. An analysis of kick-response measurements independently revealed an optics error left of point 3, and confirmed the inversion of the odd-numbered trim quadrupoles in this sector. After changing the polarity of the suspected set of quadrupoles prior to the second injection test on August 24, the measured dispersion nicely traced the model prediction

Machine studies during beam commissioning of the SPS-to-LHC transfer lines

Through May to September 2008, further beam commissioning of the SPS-to-LHC transfer lines was performed. For the first time, optics and dispersion measurements were also taken in the last part of the lines, and into the LHC. Extensive trajectory and optics studies were conducted, in parallel with hardware checks. In particular dispersion measurements and their comparison with the beam line model were analysed in detail and led to propose the addition of a dispersion-free steering algorithm in the existing trajectory correction program. Its effectiveness was simulated and is briefly discussed

Independent test assessment using the extreme value distribution theory

The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of reliable associations by the overreduction of statistical power. In this report, we examine 2 alternative approaches to improve the statistical power of a whole genome association study to detect reliable genetic associations. The approaches were tested using the Genetic Analysis Workshop 19 (GAW19) whole genome sequencing data. The first tested method estimates the real number of effective independent tests actually being performed in whole genome association project by the use of an extreme value distribution and a set of phenotype simulations. Given the familiar nature of the GAW19 data and the finite number of pedigree founders in the sample, the number of correlations between genotypes is greater than in a set of unrelated samples. Using our procedure, we estimate that the effective number represents only 15 % of the total number of independent tests performed. However, even using this corrected significance threshold, no genome-wide significant association could be detected for systolic and diastolic blood pressure traits. The second approach implements a biological relevance-driven hypothesis tested by exploiting prior computational predictions on the effect of nonsynonymous genetic variants detected in a whole genome sequencing association study. This guided testing approach was able to identify 2 promising single-nucleotide polymorphisms (SNPs), 1 for each trait, targeting biologically relevant genes that could help shed light on the genesis of the human hypertension. The first gene, PFH14, associated with systolic blood pressure, interacts directly with genes involved in calcium-channel formation and the second gene, MAP4, encodes a microtubule-associated protein and had already been detected by previous genome-wide association study experiments conducted in an Asian population. Our results highlight the necessity of the development of alternative approached to improve the efficiency on the detection of reasonable candidate associations in whole genome sequencing studies

Feed forward in the LHC

The LHC operational cycle is comprised of several phases such as the ramp, the squeeze and stable beams. During the ramp and squeeze in particular, it has been ob- served that the behaviour of key LHC beam parameters such as tune, orbit and chromaticity is highly reproducible from fill to fill. To reduce the reliance on the crucial feed- back systems, it was decided to perform fill-to-fill feed- forward corrections. The LHC feed-forward application was developed to ease the introduction of corrections to the operational settings. The LHC Feed-Forward software has been used during LHC commissioning and tune and orbit corrections during ramp and squeeze have been suc- cessfully applied. As a result, the required real-time cor- rections for the above parameters have been reduced to a minimum. In parallel, successful trials have been made to apply feedforward corrections before commissioning with beam which are based on M AD - X simulation scans over the unused setting functions. In this paper we present the evolution of feedforward for the LHC and discuss further improvements of this software

Independent test assessment using the extreme value distribution theory

Abstract The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of reliable associations by the overreduction of statistical power. In this report, we examine 2 alternative approaches to improve the statistical power of a whole genome association study to detect reliable genetic associations. The approaches were tested using the Genetic Analysis Workshop 19 (GAW19) whole genome sequencing data. The first tested method estimates the real number of effective independent tests actually being performed in whole genome association project by the use of an extreme value distribution and a set of phenotype simulations. Given the familiar nature of the GAW19 data and the finite number of pedigree founders in the sample, the number of correlations between genotypes is greater than in a set of unrelated samples. Using our procedure, we estimate that the effective number represents only 15 % of the total number of independent tests performed. However, even using this corrected significance threshold, no genome-wide significant association could be detected for systolic and diastolic blood pressure traits. The second approach implements a biological relevance-driven hypothesis tested by exploiting prior computational predictions on the effect of nonsynonymous genetic variants detected in a whole genome sequencing association study. This guided testing approach was able to identify 2 promising single-nucleotide polymorphisms (SNPs), 1 for each trait, targeting biologically relevant genes that could help shed light on the genesis of the human hypertension. The first gene, PFH14, associated with systolic blood pressure, interacts directly with genes involved in calcium-channel formation and the second gene, MAP4, encodes a microtubule-associated protein and had already been detected by previous genome-wide association study experiments conducted in an Asian population. Our results highlight the necessity of the development of alternative approached to improve the efficiency on the detection of reasonable candidate associations in whole genome sequencing studies.http://deepblue.lib.umich.edu/bitstream/2027.42/134747/1/12919_2016_Article_38.pd