58 research outputs found
Reproducibility of different screening classifications in ultrasonography of the newborn hip
<p>Abstract</p> <p>Background</p> <p>Ultrasonography of the hip has gained wide acceptance as a primary method for diagnosis, screening and treatment monitoring of developmental hip dysplasia in infants. The aim of the study was to examine the degree of concordance of two objective classifications of hip morphology and subjective parameters by three investigators with different levels of experience.</p> <p>Methods</p> <p>In 207 consecutive newborns (101 boys; 106 girls) the following parameters were assessed: bony roof angle (α-angle) and cartilage roof angle (β-angle) according to Graf's basic standard method, "femoral head coverage" (FHC) as described by Terjesen, shape of the bony roof and position of the cartilaginous roof. Both hips were measured twice by each investigator with a 7.5 MHz linear transducer (SONOLINE G60S<sup>® </sup>ultrasound system, SIEMENS, Erlangen, Germany).</p> <p>Results</p> <p>Mean kappa-coefficients for the subjective parameters shape of the bony roof (0.97) and position of the cartilaginous roof (1.0) demonstrated high intra-observer reproducibility. Best results were achieved for α-angle, followed by β-angle and finally FHC. With respect to limits of agreement, inter-observer reproducibility was calculated less precisely.</p> <p>Conclusions</p> <p>Higher measurement differences were evaluated more in objective scorings. Those variations were observed by every investigator irrespective of level of experience.</p
Measurement of isotopic separation of argon with the prototype of the cryogenic distillation plant Aria for dark matter searches
The Aria cryogenic distillation plant, located in Sardinia, Italy, is a key component of the DarkSide-20k experimental program for WIMP dark matter searches at the INFN Laboratori Nazionali del Gran Sasso, Italy. Aria is designed to purify the argon, extracted from underground wells in Colorado, USA, and used as the DarkSide-20k target material, to detector-grade quality. In this paper, we report the first measurement of argon isotopic separation by distillation with the 26 m tall Aria prototype. We discuss the measurement of the operating parameters of the column and the observation of the simultaneous separation of the three stable argon isotopes: 36Ar , 38Ar , and 40Ar . We also provide a detailed comparison of the experimental results with commercial process simulation software. This measurement of isotopic separation of argon is a significant achievement for the project, building on the success of the initial demonstration of isotopic separation of nitrogen using the same equipment in 2019
Study on cosmogenic activation above ground for the DarkSide-20k project
The activation of materials due to the exposure to cosmic rays may become an
important background source for experiments investigating rare event phenomena.
DarkSide-20k is a direct detection experiment for galactic dark matter
particles, using a two-phase liquid argon time projection chamber filled with
49.7 tonnes (active mass) of Underground Argon (UAr) depleted in 39Ar. Here,
the cosmogenic activity of relevant long-lived radioisotopes induced in the
argon and other massive components of the set-up has been estimated; production
of 120 t of radiopure UAr is foreseen. The expected exposure above ground and
production rates, either measured or calculated, have been considered. From the
simulated counting rates in the detector due to cosmogenic isotopes, it is
concluded that activation in copper and stainless steel is not problematic.
Activation of titanium, considered in early designs but not used in the final
design, is discussed. The activity of 39Ar induced during extraction,
purification and transport on surface, in baseline conditions, is evaluated to
be 2.8% of the activity measured in UAr from the same source, and thus
considered acceptable. Other products in the UAr such as 37Ar and 3H are shown
to not be relevant due to short half-life and assumed purification methods
Directionality of nuclear recoils in a liquid argon time projection chamber
The direct search for dark matter in the form of weakly interacting massive
particles (WIMP) is performed by detecting nuclear recoils (NR) produced in a
target material from the WIMP elastic scattering. A promising experimental
strategy for direct dark matter search employs argon dual-phase time projection
chambers (TPC). One of the advantages of the TPC is the capability to detect
both the scintillation and charge signals produced by NRs. Furthermore, the
existence of a drift electric field in the TPC breaks the rotational symmetry:
the angle between the drift field and the momentum of the recoiling nucleus can
potentially affect the charge recombination probability in liquid argon and
then the relative balance between the two signal channels. This fact could make
the detector sensitive to the directionality of the WIMP-induced signal,
enabling unmistakable annual and daily modulation signatures for future
searches aiming for discovery. The Recoil Directionality (ReD) experiment was
designed to probe for such directional sensitivity. The TPC of ReD was
irradiated with neutrons at the INFN Laboratori Nazionali del Sud, and data
were taken with 72 keV NRs of known recoil directions. The direction-dependent
liquid argon charge recombination model by Cataudella et al. was adopted and a
likelihood statistical analysis was performed, which gave no indications of
significant dependence of the detector response to the recoil direction. The
aspect ratio R of the initial ionization cloud is estimated to be 1.037 +/-
0.027 and the upper limit is R < 1.072 with 90% confidence levelComment: 20 pages, 10 figures, submitted to Eur. Phys. J.
Study of cosmogenic activation above ground for the DarkSide-20k experiment
The activation of materials due to exposure to cosmic rays may become an important background source for experiments investigating rare event phenomena. DarkSide-20k, currently under construction at the Laboratori Nazionali del Gran Sasso, is a direct detection experiment for galactic dark matter particles, using a two-phase liquid-argon Time Projection Chamber (TPC) filled with 49.7 tonnes (active mass) of Underground Argon (UAr) depleted in 39Ar. Despite the outstanding capability of discriminating
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background in argon TPCs, this background must be considered because of induced dead time or accidental coincidences mimicking dark-matter signals and it is relevant for low-threshold electron-counting measurements. Here, the cosmogenic activity of relevant long-lived radioisotopes induced in the experiment has been estimated to set requirements and procedures during preparation of the experiment and to check that it is not dominant over primordial radioactivity; particular attention has been paid to the activation of the 120 t of UAr used in DarkSide-20k. Expected exposures above ground and production rates, either measured or calculated, have been considered in detail. From the simulated counting rates in the detector due to cosmogenic isotopes, it is concluded that activation in copper and stainless steel is not problematic. The activity of 39Ar induced during extraction, purification and transport on surface is evaluated to be 2.8% of the activity measured in UAr by DarkSide-50 experiment, which used the same underground source, and thus considered acceptable. Other isotopes in the UAr such as 37Ar and 3H are shown not to be relevant due to short half-life and assumed purification methods
Sensitivity projections for a dual-phase argon TPC optimized for light dark matter searches through the ionization channel
Sensitivity projections for a dual-phase argon TPC optimized for light dark matter searches through the ionization channel
Dark matter lighter than 10 GeV/c2 encompasses a promising range of candidates. A conceptual design for a new detector, DarkSide-LowMass, is presented, based on the DarkSide-50 detector and progress toward DarkSide-20k, optimized for a low-threshold electron-counting measurement. Sensitivity to light dark matter is explored for various potential energy thresholds and background rates. These studies show that DarkSide-LowMass can achieve sensitivity to light dark matter down to the solar neutrino fog for GeV-scale masses and significant sensitivity down to 10 MeV/c2 considering the Migdal effect or interactions with electrons. Requirements for optimizing the detector’s sensitivity are explored, as are potential sensitivity gains from modeling and mitigating spurious electron backgrounds that may dominate the signal at the lowest energies
miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives
Sprawozdanie z międzynarodowej konferencji naukowej pt. "Ekonomiczne i społeczne uwarunkowania rozwoju polskiej gospodarki żywnościowej po wstąpieniu Polski do Unii Europejskiej"
Sprawozdanie z seminarium "Ocena stanu polskiej gospodarki żywnościowej po wejściu Polski do UE"
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