85 research outputs found

    Creating a database for Tibeto-Burman languages

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    In the number of its speakers, Tibeto-Burman is one of the largest language families in the world. The language family, however, has received little scholarly attention and its composition and history remain poorly understood. Many languages are still awaiting detailed documentation and description - a task that is becoming urgent as smaller languages fall victim to socio-economic and demographic pressures. Given the dazzling linguistic diversity and sheer number of languages yet to be studied, a thorough understanding of the Tibeto-Burman language family poses great challenges. One complicating factor is that presently available data are scattered, making an overview of the family and adequate historical comparisons unfeasible

    Electronic Entropy Change in Ni-doped FeRh

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    The net entropy change corresponding to the free charge carriers in a Ni-doped FeRh bulk polycrystal was experimentally evaluated in a single sample using low-temperature heat capacity experiments with applied magnetic field and using Seebeck effect and Hall coefficient measurements at high temperatures across the first-order phase transition. From the heat capacity data, a value for the electronic entropy change ΔSel≈8.9 J kg−1K−1 was extracted. The analysis of the Seebeck coefficient allows tracing the change of the electronic entropy jump with applied magnetic field directly across the transition. The difference in electronic entropy contribution obtained is as high as 10% from 0.1 to 6 T. © 2019 Elsevier Ltd.The authors thank Dr. Sebastian Fahler for insightful discussions. TU Darmstadt acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant no. 743116 project Cool Innov)

    Analysis of risk factors and tactics of management of patients with synechia of the labia minor

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    The purpose of the study is the assessment of risk factors for the formation of synechia of the labia minora in girls of preschool age and the development of an algorithm for the treatment of synechia, taking into account risk factors.Цель исследования – оценка факторов риска формирования синехий малых половых губ у девочек дошкольного возраста и разработку алгоритма лечения синехий с учетом факторов риска

    EGFR interacts with the fusion protein of respiratory syncytial virus strain 2-20 and mediates infection and mucin expression.

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    Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to the RSV prototypic strain A2, clinical isolate RSV 2-20 induces airway mucin expression in mice, a clinically relevant phenotype dependent on the fusion (F) protein of the RSV strain. Epidermal growth factor receptor (EGFR) plays a role in airway mucin expression in other systems; therefore, we hypothesized that the RSV 2-20 F protein stimulates EGFR signaling. Infection of cells with chimeric strains RSV A2-2-20F and A2-2-20GF or over-expression of 2-20 F protein resulted in greater phosphorylation of EGFR than infection with RSV A2 or over-expression of A2 F, respectively. Chemical inhibition of EGFR signaling or knockdown of EGFR resulted in diminished infectivity of RSV A2-2-20F but not RSV A2. Over-expression of EGFR enhanced the fusion activity of 2-20 F protein in trans. EGFR co-immunoprecipitated most efficiently with RSV F proteins derived from "mucogenic" strains. RSV 2-20 F and EGFR co-localized in H292 cells, and A2-2-20GF-induced MUC5AC expression was ablated by EGFR inhibitors in these cells. Treatment of BALB/c mice with the EGFR inhibitor erlotinib significantly reduced the amount of RSV A2-2-20F-induced airway mucin expression. Our results demonstrate that RSV F interacts with EGFR in a strain-specific manner, EGFR is a co-factor for infection, and EGFR plays a role in RSV-induced mucin expression, suggesting EGFR is a potential target for RSV disease

    T cells at the site of autoimmune inflammation show increased potential for trogocytosis

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    CD4+ T cells acquire membrane fragments from antigen-presenting-cells via a process termed trogocytosis. Identifying which CD4+ T cells undergo trogocytosis in co-culture with Ag-loaded APC can enrich for antigen-reactive T cells without knowledge of their fine specificity or cytokine-production profiles. We sought to assess the suitability of this method to identify disease relevant effector and regulatory T cells during autoimmune inflammation. Trogocytosis efficiently identified MBP-reactive T cells in vitro and ex-vivo following immunization. However, Foxp3+ regulatory T cells constitutively displayed a higher rate of trogocytosis than their Foxp3- counterparts which limits the potential of trogocytosis to identify antigen-reactive Treg cells. During inflammation a locally elevated rate of trogocytosis (seen in both effector and regulatory T cells isolated from the inflamed CNS) precludes the use of trogocytosis as a measure of antigenic reactivity among cells taken from inflammatory sites. Our results indicate trogocytosis detection can enrich for Ag-reactive conventional T cells in the periphery but is limited in its ability to identify Ag-reactive Treg or T effector cells at sites of inflammation. Increased trogocytosis potential at inflammatory sites also draws into the question the biological significance of this phenomenon during inflammation, in Treg mediated suppression and for the maintenance of tolerance in health and disease

    Creating a database for Tibeto-Burman languages

    No full text
    In the number of its speakers, Tibeto-Burman is one of the largest language families in the world. The language family, however, has received little scholarly attention and its composition and history remain poorly understood. Many languages are still awaiting detailed documentation and description - a task that is becoming urgent as smaller languages fall victim to socio-economic and demographic pressures. Given the dazzling linguistic diversity and sheer number of languages yet to be studied, a thorough understanding of the Tibeto-Burman language family poses great challenges. One complicating factor is that presently available data are scattered, making an overview of the family and adequate historical comparisons unfeasible
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