4 research outputs found
DETERMINATION OF THE INITIAL CONDITIONS OF ROAD TRAFFIC ACCIDENTS IN THEIR CONSEQUENCES
Developed a calculation-experimental method of determining the initial conditions of road traffic accidents in their consequences in the event of a frontal collision
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Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue
Brown adipose tissue (BAT) is a key thermogenic organ whose expression of uncoupling protein 1 (UCP1) and ability to maintain body temperature in response to acute cold exposure require histone deacetylase 3 (HDAC3). HDAC3 exists in tight association with nuclear receptor corepressors (NCoRs) NCoR1 and NCoR2 (also known as silencing mediator of retinoid and thyroid receptors [SMRT]), but the functions of NCoR1/2 in BAT have not been established. Here we report that as expected, genetic loss of NCoR1/2 in BAT (NCoR1/2 BAT-dKO) leads to loss of HDAC3 activity. In addition, HDAC3 is no longer bound at its physiological genomic sites in the absence of NCoR1/2, leading to a shared deregulation of BAT lipid metabolism between NCoR1/2 BAT-dKO and HDAC3 BAT-KO mice. Despite these commonalities, loss of NCoR1/2 in BAT does not phenocopy the cold sensitivity observed in HDAC3 BAT-KO, nor does loss of either corepressor alone. Instead, BAT lacking NCoR1/2 is inflamed, particularly with respect to the interleukin-17 axis that increases thermogenic capacity by enhancing innervation. Integration of BAT RNA sequencing and chromatin immunoprecipitation sequencing data revealed that NCoR1/2 directly regulate Mmp9, which integrates extracellular matrix remodeling and inflammation. These findings reveal pleiotropic functions of the NCoR/HDAC3 corepressor complex in BAT, such that HDAC3-independent suppression of BAT inflammation counterbalances stimulation of HDAC3 activity in the control of thermogenesis
New developments in the pathology of malignant lymphoma: a review of the literature published from May to August 2017
Glanders & Melioidosis: A Zoonosis and a Sapronosis—“Same Same, but Different”
Glanders, caused by infection with Burkholderia mallei, primarily causes infection in equines, but may be transmitted to humans, and thus qualifies as a true zoonosis. Melioidosis Melioidosis is caused by B. pseudomallei, genetically very similar to B. mallei, but which is an environmental saprophyte capable of infecting humans and a wide range of other animals. Good evidence of animal-to-human, or even human-to-human, transmission of melioidosis is lacking, and so it most appropriately referred to as a sapronosis, or at most a sapro-zoonosis. Although rare in Western countries, both micro-organisms have recently gained much interest because of their potential use as bioterrorism agents Bioterrorism. The increasing recognition of melioidosis in humans and recent outbreaks of glanders Glanders in animals have led to their description as emerging or re-emerging diseases. Laboratory-associated infections with both organisms have also occurred, resulting in their categorisation as Hazard Group 3 pathogens. In this chapter we review the epidemiology of animal and human cases of glanders and melioidosis, the evidence for different modes of transmission, pathogenesis and clinical features, diagnosis and treatment, as well as public health and disease control issues