An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 ( GLIS3 )

Neonatal diabetes and hypothyroidism (NDH) syndrome was first described in 2003 in a consanguineous Saudi Arabian family where two out of four siblings were reported to have presented with proportionate IUGR, neonatal non-autoimmune diabetes mellitus, severe congenital hypothyroidism, cholestasis, congenital glaucoma, and polycystic kidneys. Liver disease progressed to hepatic fibrosis. The renal disease was characterised by enlarged kidneys and multiple small cysts with deficient cortico-medullary junction differentiation and normal kidney function. There was minor facial dysmorphism (depressed nasal bridge, large anterior fontanelle, long philtrum) reported but no facial photographs were published. Mutations in the transcription factor GLI-similar 3 (GLIS3) gene in the original family and two other families were subsequently reported in 2006. All affected individuals had neonatal diabetes, congenital hypothyroidism but glaucoma and liver and kidney involvement were less consistent features. Detailed descriptions of the facial dysmorphism have not been reported previously. In this report, we describe the common facial dysmorphism consisting of bilateral low-set ears, depressed nasal bridge with overhanging columella, elongated, upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations and report the emergence of a distinct, probably recognisable facial gestalt in this group which evolves with age

The influence of implicit theories and offender characteristics on judgements of sexual offenders: a moderated mediation analysis

The psychological factors underpinning responses to sexual offenders are beginning to receive increased empirical scrutiny. One such factor is offender representativeness, which refers to the extent to which a given offender example matches a stereotype of those who are typically labelled as 'sexual offenders'. Using a sample of 252 community members, we examined the role of implicit theories about sexual offenders (i.e., whether sexual offending is seen as fixed or malleable) in mediating the relationship between affective responses to sexual offenders and policy outcome judgements. We found support for this mediating effect, although this was eliminated when participants were presented with a 'non-representative' offender vignette. We argue that the relationship between affective responses and policy judgements is contingent on the activation of a sexual offender stereotype, and that this link can be disrupted via the increased presentation of non-stereotypical case examples. Implications for public debate and professional practice are discussed

A New Large-Well 1024x1024 Si:As Detector for the Mid-Infrare

We present a description of a new 1024x1024 Si:As array designed for ground-based use from 5 - 28 microns. With a maximum well depth of 5e6 electrons, this device brings large-format array technology to bear on ground-based mid-infrared programs, allowing entry to the megapixel realm previously only accessible to the near-IR. The multiplexer design features switchable gain, a 256x256 windowing mode for extremely bright sources, and it is two-edge buttable. The device is currently in its final design phase at DRS in Cypress, CA. We anticipate completion of the foundry run in the beginning of 2006. This new array will enable wide field, high angular resolution ground-based follow up of targets found by space-based missions such as the Spitzer Space Telescope and the Widefield Infrared Survey Explorer (WISE).Comment: 8 pages, 9 figures, 2005 San Diego SPI

"A different world" exploring and understanding the climate of a recently re-rolled sexual offender prison

Understanding how sexual offenders experience prison and its environment is important because such experiences can impact on rehabilitation outcomes. The purpose of this research investigation was to explore the rehabilitative and therapeutic climate of a recently re-rolled sexual offender prison. The research took a mixed methods approach and consisted of quantitative and qualitative phases. There were differences between prisoners and staff on their perception of the prison climate and for prisoner and staff relationships. The qualitative results helped to explain the quantitative findings and added a more nuanced understanding of the experience of the prison, the nature of prisoner and staff relationships and the opportunities for personal growth within the prison. The study has important implications for prisons that co-locate sexual offenders and want to provide an environment conducive to rehabilitation

Different effects of dual task demands on the speech of young and older adults

This is an electronic version of an article published in Kemper, S., Herman, R. E., Nartowicz, J.(2005). Different effects of dual task demands on the speech of young and older adults. Aging, Neuropsychology, and Cognition, 12, 340-358. PM#1410812. Aging, Neuropsychology, and Cognition is available online at www.taylorandfrancis.comYoung and older adults provided language samples in response to elicitation questions while concurrently performing 3 different tasks. The language samples were scored on three dimensions: fluency, grammatical complexity, and content. Previous research has shown that older adults use a restricted speech register that is grammatically less complex than young adults’ and has suggested that this restricted speech register is buffered from the costs of dual task demands. This hypothesis was tested by comparing language samples collected during a baseline condition with those produced while the participants were performing the concurrent tasks. The results indicate that young and older adults adopt different strategies when confronted with dual task demands. Young adults shift to a restricted speech register when confronted with dual task demands. Older adults, who were already using a restricted speech register, became less fluent although the grammatical complexity and informational content of their speech was preserved. Hence, some but not all aspects of older adults’ speech are buffered from dual task demands

Análisis de costos y gastos para la determinación de la cuota adecuada de alquiler-venta a los socios de la empresa Transportes Huanchaco S.A. de Trujillo

RESUMEN El presente trabajo de investigación tiene como principal propósito, aportar a la Empresa de Transportes Huanchaco, la determinación de una cuota adecuada de alquiler venta que se cobrará al socio. El objetivo que persigue es determinar si el análisis de costos y gastos permitirá identificar una cuota adecuada de alquiler venta, la cual se le cobrará al socio. Esta identificación se realiza mediante la observación, análisis y clasificación de cada costo (costo de adquisición y costo por el servicio de alquiler) y gastos (gastos administrativos y financieros). La cuota adecuada está compuesta por los costos y gastos antes mencionados de acuerdo al análisis realizado, además se agregó un porcentaje mínimo de rentabilidad por el servicio prestado, con el objeto de no tener diferencias tributarias con SUNAT, más el Impuesto General a las Ventas, que debe ser asumido en sus totalidad por el socio. En el análisis de la cuota cobrada anteriormente se precisaron contingencias tributarias, tales como impuestos presuntos, los cuales pueden afectar a la empresa con sanciones tributarias, por lo que en esta investigación se determinó el importe de estos impuestos omitidos y las multas que se ocasionarían en una posible fiscalización. Las autoras realizan esta investigación con fines académicos y a espera de que la propuesta de la nueva cuota adecuada sirva como base para que a partir de la fecha y futuros planes semejantes sirvan como base y motiven a la Junta General de Accionistas continuar trabajando en la renovación de sus flotas sin perjuicio a la Empresa de Transportes Huanchaco S.A.ABSTRACT The main purpose of this research is to provide the “Empresa de Transportes Huanchaco S.A” with the final figure of an appropriate rental-sale fee, whick will be charged to the associated partners. The objective is to establish whether the cost and expense analysis will deliver an appropriate fee for rental-sales services, which will be charged to the partners. This setting is made through observation, analysis and classification of each cost (cost of acquisition and cost for the rental service) and expenses (administrative and financial expenses) The appropriate fee consists of the costs and expenses mentioned before according to the analysis made, plus a minimum percentage of profitability added for the service provided, in order not to have tax differences with SUNAT plus the General Sales Tax, that must be totally assumed by the partner. In the analysis of the quoted fee previously mentioned tax contingencies were included, such as estimated taxes, those which may affect the company’s liability to tax penalties, therefore in this investigation it was determined the amount of these omitted taxes and the fines that would be incurred in a possible audit. The authors carry out this research for academic purposes and are waiting for the new proposed fee to serve as a basis from now on and for future similar plans and motivate the General Shareholders’ Meeting to continue working on the renewal of its fleet without harm to the Transporte Huanchaco Company S

"We're all the same here"—Investigating the rehabilitative climate of a re-rolled sexual offender prison: a qualitative longitudinal study

Understanding how individuals with sexual convictions experience prison and its environment is important because such experiences can impact on rehabilitation outcomes. This is the first qualitative longitudinal investigation that explores the experiences of prisoners in a prison exclusively for individuals with sexual convictions over time. The purpose of this research was to explore the rehabilitative and therapeutic climate of a recently re-rolled prison (a general prison turned into a prison only for individuals who have sexually offended) at two time points (T1 at reroll and T2 a year later). The study focuses on prisoners perspectives of the purpose of the prison, experience of prison life, relationships in the prison, and the prison regime over time. Twenty interviews were conducted across the time points and revealed two main superordinate themes “‘Being’ in a prison for individuals with sexual convictions” and “obstructions to change". This research adds to the emerging body of knowledge surrounding the importance of the wider prison environment on the rehabilitation of individuals with sexual convictions and on the benefits and risks of co-locating men who have committed sexual offences in the same prison site. It also has implications wider than rehabilitation of those convicted of sexual offences and has insights for the types of environment and prisoner-staff relationships that are conducive to rehabilitation

Troubling stories of the end of occupy : feminist narratives of betrayal at occupy Glasgow

This article offers a feminist take on the question of why Occupy camps closed down, in the form of a narrative analysis of interviews from participants in Occupy Glasgow. In response to the emergence of an activist discourse emphasising the role of external forces in camp closure and the existence of a longer-term legacy in terms of individual and community politicisation, I build here on feminist interventions that point instead to serious internal problems within the camps and thus to a more limited legacy. Interrogating the plotting, characterisation and denouement of interviewee narratives, I show that feminist participants in Occupy Glasgow characterise the trajectory of the camp as a tragedy, attribute responsibility for the camp’s demise to co-campers and sometimes to themselves, and present the outcome of Occupy Glasgow as limited, and in some cases even traumatic. This raises serious questions about the culmination and outcomes of Occupy in Glasgow and more generally, and indicates the extent of the hard work remaining if future mobilisation against neoliberal austerity is to be more inclusive and sustainable. The article closes by considering the theoretical implications for the wider question of why movements come to an end

Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source

Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was chosen as it is a wellcharacterized model system, useful for proof-of-principle experiments, system optimization and algorithm development. RDV, an icosahedral virus of about 70 nm in diameter, was aerosolized and injected into the approximately 0.1 mu m diameter focused hard X-ray beam at the CXI instrument of LCLS. Diffraction patterns from RDV with signal to 5.9 angstrom ngstrom were recorded. The diffraction data are available through the Coherent X-ray Imaging Data Bank (CXIDB) as a resource for algorithm development, the contents of which are described here.11Ysciescopu

Persistent Organic Chemicals in the Pacific Basin Countries: An Overview

The Pacific Basin is a unique geographical region representing tropical, temperate and polar zones. This region is home to 2/3 of world’s population and consists of rapidly growing economies (countries) and highly developed countries. The Pacific Basin countries have had a history of use of persistent organic chemicals (POCs) at varying proportions during the last five decades. Due to diverse climatic and socio-economic conditions, the environment and biota in different countries in this basin have varying degrees of environmental contamination and effects on wildlife and humans. In this chapter, the historical background of POCs including, discovery, production, use, regulations/restrictions imposed, current status and possible future trends are reviewed especially focusing on the countries in the Pacific Rim