22 research outputs found
RECOVERY OF DAILY ACTIVITY PATTERNS IN PATIENTS AFTER ACL RECONSTRUCTION
Injuries of the anterior cruciate ligament are one of the most often occurring injuries during sports activities. For young active patients, surgical treatment with repair, augmentation or replacement of the involved structure(s) is advised. The present study compared the outcome after Ligamys repair and Semitendinosus reconstruction during the first six postoperative weeks with objective measurements of the activity/inactivity behavior in daily life
LOQTEQ® VA Periprosthetic Plate—A New Concept for Bicortical Screw Fixation in Periprosthetic Fractures: A Technical Note
Internal fixation using angle stable plates is the treatment standard in periprosthetic fractures around stable implants. To provide instant postoperative full weight-bearing, bicortical screw fixation is advisable but often surgically demanding. This work presents the first clinical results of the LOQTEQ® VA Periprosthetic Plate (aap Implantate AG, Berlin, Germany), a new plate system to simplify screw placement around implants. This plate system uses insertable hinges that allow for variable angle screw anchorage. Data of 26 patients with a mean age of 80 years and a mean follow-up of 13.9 months were retrospectively collected. Patients were clinically and radiologically examined. Bony union was achieved in 14 out of 15 patients with no signs of non-union or implant loosening. One patient, however, presented with implant failure. Clinical scores demonstrated acceptable results. Since the hinge plates are easy to apply, the first results are promising
Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma
Ziel der Arbeit: Die Uterusarterienembolisation (UAE) ist eine Therapieoption
für Patientinnen mit symptomatischen Leiomyomen des Uterus. Die vorliegende
Arbeit beschäftigt sich mit den klinischen Langzeitergebnissen in Bezug auf
Symptomkontrolle und Lebensqualität bei Patientinnen nach UAE sowie mit
möglichen Faktoren, die Therapieerfolg oder -versagen beeinflussen können.
Material und Methoden: 380 Patientinnen wurden von 10/2000 bis 10/2007
behandelt und in die Auswertung einbezogen. Mit Hilfe eines standardisierten
Fragebogens wurden Folgeeingriffe, Leiomyombeschwerden (Blutungs- und
Druckbeschwerden) und Lebensqualität abgefragt. Folgeeingriffe, eine
Verschlechterung der Symptomatik oder der Lebensqualität wurden als
Therapieversagen gewertet. Mittels Kaplan-Meier-Analyse wurde die
durchschnittliche ereignisfreie Zeit (Endpunkt: Therapieversagen) analysiert.
Um festzustellen, ob klinische und anatomischen Kriterien einen Erfolg oder
Misserfolg beeinflussen, wurde eine Cox-Regressions-Analyse genutzt. Bei einer
Subgruppe (n=115) wurde 48 – 72 Stunden nach UAE eine
kontrastmittelunterstützte Magnetresonanztomographie (MRT) durchgeführt und
ein Zusammenhang zwischen Infarzierung des Leiomyomgewebes und klinischem
Erfolg geprüft. Um einen Zusammenhang zwischen Beschwerden und anatomischen
Ausgangsdaten treffen zu können, wurde eine Subgruppe (n=91) mit singulären
Leiomyomen untersucht. Ergebnisse: Von 304 der 380 Patientinnen (80 %)
erhielten wir verwertbare Antworten. Die Verlaufskontrolle erstreckte sich im
Median über 5,7 Jahre (Spannweite: 3,1 – 10,1 Jahren) nach UAE. Die Kaplan-
Meier-Analyse zeigte nach 10 Jahren ein Therapieversagen bei 23,3 % der
behandelten Patientinnen. Patientinnen unter 40 Jahren weisen ein signifikant
höheres Risiko für ein Therapieversagens im Verlaufszeitraum auf (Hazard
Ratio: 2,28, p=0,049). Patientinnen nach UAE ohne Therapieversagen wiesen im
Langzeitverlauf vergleichbare Werte der Lebensqualität zu dem eines nicht
erkrankten Kollektivs auf (p<0,001). Patientinnen mit einer Infarzierung der
Leiomyome unter 89 % hatten ein 22,2-fach erhöhtes Risiko (p<0,001) für ein
Therapieversagen gegenüber der Gruppe mit 90 – 99% und 100 % Infarzierung. Bei
Patientinnen mit reinen Blutungsbeschwerden und einer Infarzierung unter 89 %
ist ein 40,5-fach höheres Risiko eines Therapieversagens im Vergleich zu einer
Gruppe mit Blutungs- und Druckbeschwerden oder einer Infarzierung über 90 % zu
verzeichnen. Es konnte kein signifikanter Zusammenhang zwischen den
anatomischen Ausgangsdaten und Leiomyombeschwerden gezeigt werden.
Schlussfolgerungen: Die UAE zur Behandlung symptomatischer Uterusmyome zeigt
im Langzeitverlauf bei etwa 75 % der Patientinnen eine anhaltende Besserung
der Leiomyombeschwerden und verschafft behandelten Patientinnen eine
Lebensqualität, die der nicht betroffener Frauen vergleichbar ist. Es besteht
keine Korrelation zwischen anatomischen Faktoren und Leiomyombeschwerden.
Patientinnen < 40 Jahren mit reinen Blutungsstörungen haben ein höheres Risiko
für ein Therapieversagen. Ein prognostischer Faktor für einen Langzeiterfolg
ohne Re-Intervention ist die Infarzierung des Myomgewebes zu über 90 %.Purpose: Uterine artery embolisation (UAE) is a therapeutic option for
patients with symptomatic leiomyomata fibroids of the uterus. The study
presented here, evaluates the clinical long-term results of this procedure
with regard to symptom control and quality-of-life of as well as factors that
may influence therapeutic success or failure. Material and Methods: Between
10/2000 and 10/2007 380 patients were treated and included in this analysis.
Using an standardized questionnaire data on re-interventions, fibroid-related
symptoms (bleeding and pressure symptoms) and quality-of-life were collected.
Re-interventions, worsening of fibroid-related symptoms or quality-of-life
were defined as a failure of therapy. Using a Kaplan-Meier-Analysis the event-
free survival (endpoint: therapy failure) was calculated. A cox regression
analysis was carried out to determine if clinical or anatomical factors
influence clinical outcome. A subgroup of patients (n=115) underwent contrast-
enhanced MRI to investigate the relationship between infarction of fibroids
and clinical outcome. Another subgroup of patients (n=91) with single fibroids
were analyzed to determine if anatomical factors relate to the type of
symptoms. Results: 304 of 380 patients (80 %) returned information that could
be analyzed. Median follow-up was 5,7 years (range: 3,1 – 10,1 years). Kaplan-
Meier-Analysis showed that ten years after UAE up to 23,3 % of women reported
failure of therapy. Cox-regression analysis demonstrated that patients under
the age of forty have a significant higher risk of clinical failure (Hazard
Ratio: 2,28, p=0,049). Patients with a positive long-term result after UAE
reported similiar Quality-of-life compared to a a group of patients without
fibroids (p<0,001). Patients with an infarction rate of leiomyoma below 89 %
had a 22,2-fold higher risk for therapy failure than women with a 90-99 % or
100 % infarction rate (p<0,001). The combination bleeding symptoms and an
infarction rate of less than 89% was associated with a 40,5-fold increased
risk for therapy failure as compared to a group of women with pressure and
bleeding symptoms or an infarction rate >90%. No correlation between
anatomical variables and fibroid-related symptoms could be found. Conclusion:
UAE for symptomatic fibroids leads to long-term symptom control in 75 % of
women and is associated with an improvement in quality-of-life comparable to
women without disease. No correlation between anatomical factors and clinical
symptoms was found. Women under age of 40 and bleeding symptoms are a higher
risk for clinical failure after UAE. An infarction rate of > 90% of leiomyoma
tissue after UAE is a strong positive predictor for clinical success
Cost-utility analysis of dynamic intraligamentary stabilization versus early reconstruction after rupture of the anterior cruciate ligament
Objectives
The aim of this study was to evaluate the cost-effectiveness of the dynamic intraligamentary stabilization (DIS) technique in comparison with reconstructive surgery (ACLR) in the treatment of isolated anterior cruciate ligament (ACL) ruptures from the perspective of the community of insured citizens in Germany.
Methods
Because of the specific decision problem at hand, namely that with DIS the procedure has to take place within 21 days after the initial trauma, a decision tree was developed.
The time horizon of the model was set to 3 years. Input data was taken from official tariffs, payer data, the literature and assumptions based on expert opinion when necessary.
Results
The decision tree analysis identified the DIS strategy as the superior one with 2.34 QALY versus 2.26 QALY for the ACLR branch. The higher QALY also came with higher costs of 5,398.05 € for the DIS branch versus 4,632.68 € for the ACLR branch respectively, leading to an ICER of 9,092.66 € per QALY. Results were robust after sensitivity analysis. Uncertainty was examined via probabilistic sensitivity analysis resulting in a slightly higher ICER of 9,567.13 € per QALY gained.
Conclusion
The DIS technology delivers an effective treatment for the ACL rupture at a favorable incremental cost-effectiveness ratio
The Müller acetabular reinforcement ring - still an option in acetabular revision of Paprosky 2 defects? Longterm results after 10 years
Aim of this study was to measure the clinical and radiological longterm outcome after acetabular revision arthroplasty using the Müller acetabular reinforcement ring. 96 patients with 103 revision arthroplasties and a mean age of 69 years (41 to 84) were included. The mean follow-up was 10 years (range 7 – 12). The radiologic analysis reports no signs of loosening in 76 %, 17 % showed possibly loosening and 7 % probable loosening. Definite radiologic loosening has not been detected. The mean center of rotation of the hip moved 0.15 cm (SD 0.74 cm) laterally and 0.1 cm (SD 0.97 cm) cranially based on the geometrically reconstructed center of rotation. A mean score of 58 points for the Harris Hip Score (range 14 – 93) indicated a poor functional outcome, while a mean value of 96 points (range 0 – 223) for the WOMAC Index indicated good results for functional outcome in daily living. The revision arthroplasty in cases with acetabular defects using the Müller acetabular reinforcement ring shows acceptable longterm results
Peri- and Interprosthetic Femoral Fractures—Current Concepts and New Developments for Internal Fixation
Treatment of peri- and interprosthetic fractures represents a challenge in orthopedic trauma surgery. Multiple factors such as osteoporosis, polymedication and comorbidities impede therapy and the rehabilitation of this difficult fracture entity. This article summarizes current concepts and highlights new developments for the internal fixation of periprosthetic fractures. Since the elderly are unable to follow partial weight bearing, stable solutions are required. Therefore, a high primary stability is necessary. Numerous options, such as new angular stable plate systems with additional options for variable angle screw positioning, already exist and are in the process of being further improved. Lately, individually produced custom-made implants are offering interesting alternatives to treat periprosthetic fractures
Additional file 1 of 2-year results of middle-aged patients with two-compartment cartilage lesions in one knee treated with two patient specific metal implants
Additional file 1
2‐year results of middle‐aged patients with two‐compartment cartilage lesions in one knee treated with two patient specific metal implants
Abstract Purpose Focal chondral lesions of the femur are currently treated with biological repair or arthroplasty. However, some patients are not suitable for either one due to lesion size, age, or prior biological treatment attempts. While singular patient‐specific focal mini metal implants already showed good results, the outcomes of bicompartmental implantation of these implants have not been discussed in the literature yet. This study aims to evaluate clinical outcomes of patients who underwent bicompartmental implantation of two patient‐specific implants. Methods This prospective, non‐randomized, non‐comparative pilot study evaluates results up to two years after bicompartmental implantation of two implants (Episealer Implant, Episurf, Stockholm, Sweden). A damage report is compiled using a special MRI program and patient specific implants are manufactured, including 3D‐printed surgical instruments to provide exact placement of the implant. The patients were assessed repeatedly using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain during the follow‐up. Results The scores were evaluated three, 12, and 24 months after surgery and showed good results. The median in both scores improved from 37.7 for the KOOS5 preoperatively to 69.1 after 24 months and from 69 for the VAS for pain preoperatively to 9 after 24 months. Conclusion Overall, for the small study group presented, the early results are promising. With noticeable improvement in KOOS and VAS for pain after two years, patient specific implants appear to become relevant in future standardized treatment of femoral chondral lesions. Especially with bicompartmental implantation, full arthroplasty can be delayed even further. Level of Evidence I
Implant preloading in extension reduces spring length change in dynamic intraligamentary stabilization: a biomechanical study on passive kinematics of the knee
A New System for Periprosthetic Fracture Stabilization—A Biomechanical Comparison
In recent years, an increase in periprosthetic femur fractures has become apparent due to the increased number of hip replacements. In the case of Vancouver type B1 fractures, locking plate systems offer safe procedures. This study compared the distal lateral femur plate (LOQTEQ®, aap Implantate AG) with a standard L.I.S.S. LCP® (DePuy Synthes) regarding their biomechanical properties in fixation of periprosthetic femur fractures after hip arthroplasty. We hypothesized that the new LOQTEQ system has superior stability and durability in comparison. Eighteen artificial left femurs were randomized in two groups (Group A: LOQTEQ®; Group B: L.I.S.S. LCP®) and tested until failure. Failure was defined as 10° varus deformity and catastrophic implant failure (loosening, breakage, progressive bending). Axial stiffness, loads of failure, cycles of failure, modes of failure were recorded. The axial stiffness in Group A with 73.4 N/mm (SD +/− 3.0) was significantly higher (p = 0.001) than in Group B (40.7 N/mm (SD +/− 2.8)). Group A resists more cycles than Group B until 10° varus deformity. Catastrophic failure mode was plate breakage in Group A and bending in Group B. In conclusion, LOQTEQ® provides higher primary stability and tends to have higher durability