Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

Objectives: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS).Material and methods: Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status.Results: The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients (p = 0.022, p = 0.045,p = 0.001 respectively). There was a statistically significant and positive correlation between HOMA-IR and malondialdehyde values (r = 0.523, p = 0.001), between HOMA-IR and glutathione peroxidase values (r = 0.468, p = 0.001) and between HOMA-IR and zinc values (r = 0.601, p = 0.001). There was a statistically significant and negative correlation between HOMA-IR and catalase values (r = –0.493, p = 0.001).Conclusions: The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response

Successful Pregnancies in Two Patients on Chronic Haemodialysis

To discuss two pregnants with end stage renal failure. Two pregnancies delivered successfully during 37th and 38th weeks of pregnancy. Chronic renal failure patients who required dialysis can rarely become pregnant. Although there are some improvements in recent years, fetal survival is still about 50% in these patients. Most common complications are hypertension, polyhydramnios, and preterm labor. Spontaneous delivery occurs at an average of 32nd gestational week. Prematurity due to preterm labor is still the most common reason for neonatal mortality. Polyhydramnios can be prevented by increasing the dialysis dose and so duration of gestation can be prolonged and fetal survival improves. Because of two dialysis patients managed in our hospital, we aimed to investigate the recent data about chronic renal failure patients that required dialysis during pregnancy

The Baseline Serum Homocysteine Levels in Peri- and Postmenopausal Women

OBJECTIVE: To investigate the effects of perimenopause, natural menopause and surgical menopause on the baseline serum homocysteine (Hcy) levels. STUDY DESIGN: The baseline serum Hcy levels were measured in 33 perimenopausal and 153 postmenopausal women and were compared between groups RESULTS: The mean Hcy levels of perimenopausal (n=33) , natural menopausal (n=99) and surgical menopausal (n=54) women were 12,3 μmol/L, 13,4 μmol/L and 13,2 μmol/L, respectively. There were no statistically significant differences in the baseline levels of Hcy between the study groups (p=0.73). CONCLUSIONS: The baseline Hcy levels of postmenopausal women were not higher than perimenopausal women. On the other hand, there were no significant differences in the baseline Hcy levels between the natural and surgical menopausal groups

Pap Smear Screening Results in Kahramanmaraş

OBJECTIVE: To evaluate the Pap smear results in our region. STUDY DESIGN: Results of 3795 Pap smear reports, performed at Kahramanmaraş Maternity and Children Hospital were evaluated retrospectively. RESULTS: There were 68 cases (1,7%) with epithelial abnormalities consisting of 51 (1,3%) ASCUS, 12 (0,3%) ASC- H, 1 (0,02%) LSIL, 4 (0,1%) HSIL. In these pathologies the ratio of advanced epithelial abnormalities (LSIL and HSIL) were determined lower than the literature. Lower HPV infection ratios in our country when compared with the literature might be due to this. CONCLUSION: Pap smear screening can be apply infrequently, at least in the populations with low incidence of epithelial abnormalities like our region

Effect of Holiday Periods on Obstetrician’s Cesarean Desicions

OBJECTIVE: To compare the cesarean sections performed prior to public holidays in 2004 with the rates of cesarean deliv ery in other periods in Kahramanmaraş. STUDY DESIGN: A total of 3994 cesarean sections out of 11611 deliveries were analyzed retrospectively. Two different long public holiday periods were determined. The total number of cesarean deliveries in a total of ten days comprised of each five days prior to the mentioned holiday periods were taken into consideration and evaluated. RESULTS: No significant difference was found in these units between the numbers of cesarean deliveries in periods prior public holiday dates and the numbers of cesarean in other times. CONCLUSIONS: As a result of this study, it may be concluded that the tendency of physicians in cesarean indications before long off-time periods is not as effective as expected. Further detailed studies examining also the indications of cesarean sections with larger patient populations are required to make a real conclusion

Parvovirus Infection and Seropositivity in a Group of Pregnant Women

OBJECTIVE: Detection of parvovirus B19 seropositivity in a group of pregnant women. STUDY DESIGN: Parvovirus B19 IgM and IgG seropositivity was investigated in 58 pregnant women. RESULTS: None of the 58 pregnant women had parvovirus B19 IgM seropositivity and 27% (n: 16) of the patients had IgG seropositivity. CONLUSIONS: Parvovirus B19 IgG seropositivity increases in pregnants by aging and it is reported as 60- 70 %. In our study the seropositivity was lower than the rates reported in the literature. Parvovirus B 19 infection is rare during pregnancy. Maternal- to- foetal transmission during acute maternal infection is about 33 %. Most of the foetal infections are asymptomatic. Common clinic presentations are miscarriage or foetal non-immun hydrops. In our opinion, routine screening of parvovirus B 19 infection should not recommended during pregnancy and screening should be limited with the hydropic fetuses because of some reasons including rarity of acute maternal infection during pregnancy, difficulty in predicting of foetal transmission, and irrelevance with fetal anomalies, rarity of miscarriage and hydrops foetalis even if fetal infection is considered

Retrospective Evaluation of Amniocentesis Cases

OBJECTIVE: The aim of this study is to evaluate retrospectively the indications, karyotype results and complications of amniocentesis that we performed in our clinic. STUDY DESIGN: Between January 2005 and May 2008 at the Department of Obstetrics and Gynecology Clinic of Kahramanmaras Sutcu Imam University, 340 amniocentesis procedure were performed. RESULTS: The biggest amniocentesis indication group, with 47% (160 in 340), was high risk at triple test followed by the advanced maternal age with 25% (86 in 340 ). Chromosomal abnormality was found in 15 (4,4%) of 340 cases after the result of karyotype analyses. Chromosomal abnormality was determined in 3 of the 160 patient (1,8%) with high risk at triple test, 3 of the 86 patient (3,5%) with advanced maternal age, 1 of the 29 patient (3,4%) with high risk at double test, 6 of the 41 patient (14,5%) with abnormal ultrasound findings, 2 of the 7 patient (28,6%) with increased NT thickness. Six cases (1,7%) had vaginal bleeding in the week following amniocentesis and 3 of these (0,9%) ended in abortion. CONCLUSION: Although it might lead to serious complications including fetal loss, amniocentesis is the most commonly and easily performed, and reliable invasive test for prenatal diagnosis of genetic disease