FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF KETOROLAC TROMETHAMINE

Aim: Ketorolac tromethamine is used for the treatment of a number of infections including infection of joints and bones, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, anthrax, skin structural infections, and typhoid fever, and it also used in the treatment of community-acquired pneumonia, chronic bacterial prostatitis, and nosocomial pneumonia. Objective: Difficulty in swallowing (dysphasia) is a common problem of all age groups, especially the elderly and pediatrics, due to physiological changes associated with these groups. Conclusion: In the present work, it has been observed from all formulations of pre-compression and post-compression studies were given within the limit of values. The in vitro dissolution data, F1 (combination of different superdisintegrants) when compared to other formulation

Target and non-target response of Swietenia Mahagoni Jacq. chemical constituents against tobacco cutworm Spodoptera litura Fab. and earthworm, Eudrilus eugeniae

Not AvailableToxicological screening of Swietenia mahagoni Jacq. (Meliaceae, West Indies Mahogany) against the lepidopteran pest Spodoptera litura was examined. Phytochemical screening through GC-MS analysis revealed nine peaks with prominent peak area % in Bis (2-ethylhexyl) phthalate (31.5%) was observed. The larvae exposed to discriminating dosage of 100 ppm deliver significant mortality rate compare to other treatment concentrations. The lethal concentrations (LC50 and LC90) was observed at the dosage of 31.04 and 86.82 ppm respectively. Sub-lethal concentrations (30 ppm) showed higher larval and pupal durations. However, pupal weight and mean fecundity rate reduced significantly. Similarly, the adult longevity reduced significantly in dose dependent manner. Midgut histology studies showed that the methanolic extracts significantly disturbs the gut epithelial layer, lumen and brush border membrane compare to the control. The soil assay on a non-target beneficial organism, the soil indicator earthworm Eudrilus eugeniae, with extracts from S. mahagoni (200 mg/kg) showed no toxicity compared to Monocrotophos at the dosage of 10 ppm/kg. Current results suggest that this bio-rational plant product from S. mahagoni displays a significant effect to reduce lepidopteran pests with low toxicity to other beneficial species.Not Availabl