VLBI observations at 147 GHz: first detection of transatlantic fringes in bright AGN

At 147 GHz (2mm wavelength), we detected three prominent AGN (NRAO150, 3C279, 1633+382) with Very Long Baseline Interferometry (VLBI) with an angular resolution of only 18 micro-arcseconds on the baseline between two antennas in Arizona (10m HHT and 12m KittPeak) and the IRAM 30m antenna on Pico Veleta in Spain. This is a new world record in radio interferometry and astronomical imaging and opens fascinating future possibilities to directly image and study the innermost regions in Quasars and other Active Galactic Nuclei.Comment: 4 pages, 3 figures, appears in: Proceedings of the 6th European VLBI Network Symposium held on June 25th-28th in Bonn, Germany. Edited by: E. Ros, R.W. Porcas, A.P. Lobanov, and J.A. Zensu

Genome-Wide Association Study

Objective. Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome-wide association analysis of Takayasu arteritis.Methods. Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis.Results. We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 x 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 x 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 x 10(-10)). The genetic susceptibility locus in RPS9/LILRB3 lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P = 2.29 x 10(-8)). In addition, we identified candidate susceptibility genes with suggestive levels of association (P < 1 x 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B.Conclusion. Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis