Case Report The Solitary Variant of Mandibular Intraosseous Neurofibroma: Report of a Rare Entity

Neurofibroma (NF) is a benign neoplasm derived from peripheral nerve cells. NF may extend either as a solitary lesion or as part of a generalized syndrome of neurofibromatosis. Intraorally, the intraosseous variant of neurofibroma is a very rare tumor. The literature provides only few cases of solitary intraosseous neurofibroma of the mandible. We report a case of 28-year-old female who was diagnosed with a solitary intraosseous neurofibroma involving the lower left quadrant of the mandible. The present case is rare in regard to its dimensions and its location

Serum lipid profile as a prognostic marker in oral submucous fibrosis

Introduction: Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India, with high prevalence rates found in North Gujarat. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not been widely investigated with respect to the serum lipid levels. The changes in lipid profile have long been associated with cancer as lipids play a key role in the maintenance of cell integrity. Aim: To investigate the alterations and clinical significance of serum lipid profiles in OSMF patients. Materials and Methods: A total of 50 subjects were included in the study and divided into two groups. Group I consisted of 40 clinically diagnosed OSMF subjects and group II consisted of 10 healthy subjects. After taking a thorough history, clinical examination, and informed consent, all the patients were sent for lipid profile estimation, which consisted of (i) serum total cholesterol (TC), (ii) low density lipoprotein (LDL) cholesterol, (iii) high density lipoprotein (HDL) cholesterol, (iv) very low density lipoprotein (VLDL) cholesterol, and (v) serum triglycerides (TG). Results: The serum lipid levels were significantly lower in patients with OSMF than in the controls, which was most evident in stage IV OSMF. From the present results, it is evident that the level of serum lipids decreases with the progression of the disease. Conclusion: This study suggests that decrease in lipid levels may be considered as a useful marker in the early diagnosis of oral premalignant conditions like OSMF

Sex determination of human mandible using metrical parameters by computed tomography: A prospective radiographic short study

Introduction: Sex determination of unidentified human remains is very important in forensic medicine, medicolegal cases, and forensic anthropology. The mandible is the largest and hardest facial bone that commonly resists postmortem damage and forms an important source of personal identification. Additional studies have demonstrated the applicability of facial reconstruction using three-dimensional computed tomography scan (3D-CT) for the purpose of individual identification. Aim: To determine the sex of human mandible using metrical parameters by CT. Materials and Methods: The study included thirty subjects (15 males and 15 females), with age group ranging between 10 and 60 years obtained from the outpatient department of Oral Medicine and Radiology, Narsinhbhai Patel Dental College and Hospital. CT scan was performed on all the subjects, and the data obtained were reconstructed for 3D viewing. After obtaining 3D-CT scan, a total of seven mandibular measurements, i.e., gonial angle (G-angle), ramus length (Ramus-L), minimum ramus breadth and gonion-gnathion length (G-G-L), bigonial breadth, bicondylar breadth (BIC-Br), and coronoid length (CO-L) were measured; collected data were analyzed using SPSS statistical analysis program by Student's t-test. Results: The result of the study showed that out of seven parameters, G-angle, Ramus-L, G-G-L, BIC-Br, and CO-L showed a significant statistical difference (P < 0.05), with overall accuracy of 86% for males and 82% for females. Conclusion: Personal identification using mandible by conventional methods has already been proved but with variable efficacies. Advanced imaging modalities can aid in personal identification with much higher accuracy than conventional methods

Analysis of iron levels in the mucosal tissue and serum of oral submucous fibrosis patients

Introduction: Oral submucous fibrosis (OSMF), being a chronic insidious oral mucosal condition, affects most parts of the oral cavity and has a high malignant transformation rate, which is triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. Aims and Objectives: The objective of the present study was to evaluate the levels of iron, as a trace element of patients with OSMF, and its association with areca nut and betel quid chewing. Materials and Methods: The study sample comprised 30 patients who were clinically diagnosed with OSMF and 10 healthy controls. OSMF patients were categorized by clinical staging. Tissue and serum estimation of iron levels was done using Vitros 250 photometry. Results: The levels of tissue and serum iron was significantly decreased in OSMF patients when compared to controls, which was statistically significant. Conclusion: Most of the patients with OSMF chewed gutkha, as compared to the transitional form of pan masala. The betel quid and areca nut chewing habits are associated with the disease state, which may play a role in altering the tissue and serum iron levels

The Solitary Variant of Mandibular Intraosseous Neurofibroma: Report of a Rare Entity

Neurofibroma (NF) is a benign neoplasm derived from peripheral nerve cells. NF may extend either as a solitary lesion or as part of a generalized syndrome of neurofibromatosis. Intraorally, the intraosseous variant of neurofibroma is a very rare tumor. The literature provides only few cases of solitary intraosseous neurofibroma of the mandible. We report a case of 28-year-old female who was diagnosed with a solitary intraosseous neurofibroma involving the lower left quadrant of the mandible. The present case is rare in regard to its dimensions and its location