58 research outputs found

    Head-to-tail dimerization and organogelating properties of click peptidomimetics

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    Click triazole-based oligopeptides 1-3 were found to self-dimerize (K dim ≈ 10-680 M -1) in a head-to-tail fashion based on 1H variable concentration, 2D, and H/D exchange NMR, VPO, CD, FT-IR studies and Gaussian 03 simulations. The dimerization constant K dim was shown to increase with increasing number of the amino acid units. Within the same oligomeric series, the K dim value is strongly affected by the size of the C-terminal end group. The tripeptides 2 are also excellent organogelators of aromatic solvents. © 2011 American Chemical Society.link_to_subscribed_fulltex
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