16 research outputs found
Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study
Macroprolactinoma associated with Cushing’s disease, successfully treated with cabergoline
Assessment of adrenocortical function in the critically ill
The assessment of adrenocortical function in the critically ill continues to be a source of controversy. In this review we discuss the physiology of glucocorticoids, and the changes seen in critical illness. The reasons for the differences in establishing diagnostic criteria for adrenal insufficiency in the critically ill are also examined
Calcium and vitamin D metabolism in granulomatous diseases.
Overproduction of the active metabolite of vitamin D 1,25-dihydroxyvitamin D (1,25(OH)2D) has been described in sarcoidosis and other granulomatous diseases. High circulating concentrations of 1,25(OH)2D lead to increased intestinal absorption of calcium, possibly to enhanced bone resorption, and may result in hypercalcaemia and/or hypercalciuria. Data obtained in vivo and in vitro demonstrated that the unregulated production of 1,25(OH)2D lies within the granulomatous tissue and is controlled by glucocorticoids. This abnormal production of 1,25(OH)2D seems to be a general phenomenon of granulomatous processes, which is not exceptional in sarcoidosis, but appears seldom in tuberculosis. These abnormalities, however, are not pathognomonic of granulomatous processes, since they have been described in other diseases such as lymphomas.Journal ArticleResearch Support, Non-U.S. Gov'tReviewSCOPUS: re.jinfo:eu-repo/semantics/publishe