Campylobacter jejuni padermių atsparumas antimikrobinėms medžiagoms ir genomo sekoskaita pagrįstas atsparumo faktorių nustatymas

[...]. The aim of the study was to determine antimicrobial resistance phenotypes of Campylobacter jejuni isolated from different sources, and to investigate the genetic mechanisms of resistance and population structure using a single nucleotide polymorphisms-based phylogenomic analysis. Objectives of the study. 1. To investigate antimicrobial resistance of C. jejuni strains to five different antimicrobial agents with special emphasis on the multidrug resistance. 2. To analyze associations between antimicrobial resistance phenotypes and MLST genotypes. 3. To analyze genetic insights in the genetic features linked to antimicrobial resistance determinants contained in the bacterial genome. 4. To characterize C. jejuni strains using whole genome sequencing and comparative genomics for antimicrobial resistance determinants and pathogenicity factors prediction. [...]