1,284 research outputs found
Technology adoption and management innovation in construction
© ASCE 2014. This paper examines the adoption of object-based modeling software across design and construction team members during project delivery. Drawing on insights from sociology, management theory and innovation studies, the paper investigates changes surrounding technology adoption and subsequent management-based innovation. Using empirical data from a case study, analysis focuses on adoption of software, the evolution of new digital and social networks, and subsequent innovations in management. The paper has three main contributions. First, it identifies related literature and examines change processes surrounding software adoption and the management innovations that are triggered. Second, it explores rigidities in existing routines that challenge adoption and deployment, highlighting innovations that reconcile change conflicts. Third, it shows how the concept of management innovation in construction is valuable to an understanding IT adoption processes
Visual style: Qualitative and context-dependent categorization
Style is an ordering principle by which to structure artifacts in a design domain. The application of a visual order entails some explicit grouping property that is both cognitively plausible and contextually dependent. Central to cognitive-contextual notions are the type of representation used in analysis and the flexibility to allow semantic interpretation. We present a model of visual style based on the concept of similarity as a qualitative context-dependent categorization. The two core components of the model are semantic feature extraction and self-organizing maps (SOMs). The model proposes a method of categorizing two-dimensional unannotated design diagrams using both low-level geometric and high-level semantic features that are automatically derived from the pictorial content of the design. The operation of the initial model, called Q-SOM, is then extended to include relevance feedback (Q-SOM:RF). The extended model can be seen as a series of sequential processing stages, in which qualitative encoding and feature extraction are followed by iterative recategorization. Categorization is achieved using an unsupervised SOM, and contextual dependencies are integrated via cluster relevance determined by the observer's feedback. The following stages are presented: initial per feature detection and extraction, selection of feature sets corresponding to different spatial ontologies, unsupervised categorization of design diagrams based on appropriate feature subsets, and integration of design context via relevance feedback. From our experiments we compare different outcomes from consecutive stages of the model. The results show that the model provides a cognitively plausible and context-dependent method for characterizing visual style in design. Copyright © 2006 Cambridge University Press
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A pilot study for the collaborative development of new ways of visualising seasonal climate forecasts
Performance-based Design of Tall Building Envelopes using Competing Wind Load and Wind Flow Criteria
© 2017 The Authors. This paper investigates performance-based tall building design and the development of a combined architectural-urban design method focusing on the effects of wind loads on- and wind flows around tall buildings. The paper provides an overview of related buildings codes and city development design guidelines that define requirements for structural façade wind loading and urban ventilation. A review of performance-based design methods for the generation, analysis and optimization of buildings is also presented. Within this frame, an approach to performance-based tall building envelope design is proposed. The approach is aimed at addressing wind loading and wind impact requirements based on generative parametric modelling and performance analysis that integrates physical parameters at the architectural and urban scales and performance criteria can support filtering and optimization relative to prevailing wind conditions
Towards a value-centric approach to education: Implications of changing practices in construction project management
This article explores two interdependent subjects underpinning how the built environment is produced: value and integrated teamwork. The concept of value is defined as the relationship between benefits received and costs incurred. Value thereby derives from the values of the judge and in multi-stakeholder construction projects, understanding each membera??s unique value proposition is complex, forming a catalyst for integrated teamwork and interdisciplinary ways of working. These subjects are reviewed in relation to the changes occurring in practice and how they can help inform new approaches to the education of built environment professionals, giving specific attention to construction project management education. In exploring these themes, the authors first review related project management research, before focusing on construction and current trends in practice. The paper then summarises research aimed at developing better theories of value and advancing integrated teamwork in construction. A framework aimed at facilitating a move to an educational model that encompasses a value-based and multidisciplinary approach is presented, followed by discussion and future work
The Vertical Distribution of some West African Mosquitoes (Diptera,Culicidae) Over Open Farmland in a Freshwater Area of the Gambia
Mosquitoes flying at low levels over open farmland were sampled by means of electrical suction traps. These were set up at nine levels from ground level up to 6 m. From the vertical profiles obtained it was possible to recognise three patterns of behaviour: (1) a low-flying group with relatively very high densities below 1 m, comprising Mansonia (Mansonioides) spp., Aedes spp. and some species of Anopheles; (2) an intermediate group with densities rather evenly distributed at the lower levels but declining above 2-4 m, comprising A. funestus Giles, A. gambiae Giles and Culex neavei Theo.; (3) a high-flying group with catches at 6 m greater, or much greater, than at 1 m, composed of C. antennatus (Becfcer),C. thalassius Theo. and C. poicilipes (Theo.). For all species, catches after 23.00 h showed an increase in the proportion of mosquitoes taken in traps at the lower levels, this being most marked at ground level and 0-5 m. No influence of either moonlight or wind speed could be detected to account for this. Biting catches on human baits showed a generally similar pattern to suction-trap catches, although differences between baits at 1-m intervals at the higher levels were less than with unbaited traps
The potential for dietary factors to prevent or treat osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this disease will increase in the future. Focusing on compounds from the habitual diet that may prevent the onset or slow the progression of OA is a strategy that has been under-investigated to date. An approach that relies on dietary modification is clearly attractive in terms of risk/benefit and more likely to be implementable at the population level. However, before undertaking a full clinical trial to examine potential efficacy, detailed molecular studies are required in order to optimise the design. This review focuses on potential dietary factors that may reduce the risk or progression of OA, including micronutrients, fatty acids, flavonoids and other phytochemicals. It therefore ignores data coming from classical inflammatory arthritides and nutraceuticals such as glucosamine and chondroitin. In conclusion, diet offers a route by which the health of the joint can be protected and OA incidence or progression decreased. In a chronic disease, with risk factors increasing in the population and with no pharmaceutical cure, an understanding of this will be crucial
Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory.
RATIONALE: Antenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring. However, the consequences of this expansion in midbrain dopamine (DA) neurons for behavioural processes in adulthood are poorly understood, including working memory that depends on DA transmission in the prefrontal cortex (PFC). OBJECTIVES: We therefore investigated the influence of antenatal glucocorticoid treatment (AGT) on the modulation of spatial working memory by a D1 receptor agonist and on D1 receptor binding and DA content in the PFC and striatum. METHODS: Pregnant rats received AGT on gestational days 16-19 by adding dexamethasone to their drinking water. Male offspring reared to adulthood were trained on a delayed alternation spatial working memory task and administered the partial D1 agonist SKF38393 (0.3-3 mg/kg) by systemic injection. In separate groups of control and AGT animals, D1 receptor binding and DA content were measured post-mortem in the PFC and striatum. RESULTS: SKF38393 impaired spatial working memory performance in control rats but had no effect in AGT rats. D1 binding was significantly reduced in the anterior cingulate cortex, prelimbic cortex, dorsal striatum and ventral pallidum of AGT rats compared with control animals. However, AGT had no significant effect on brain monoamine levels. CONCLUSIONS: These findings demonstrate that D1 receptors in corticostriatal circuitry down-regulate in response to AGT. This compensatory effect in D1 receptors may result from increased DA-ergic tone in AGT rats and underlie the resilience of these animals to the disruptive effects of D1 receptor activation on spatial working memory.The authors’ research is funded by the Wellcome
Trust (grant number 086871/Z/08/Z), the MRC (G0701500), a joint
award from the MRC (G1000183) and Wellcome Trust (093875/Z/10/
Z) in support of the Behavioral and Clinical Neuroscience Institute at
Cambridge University, and an MRC strategic award to the Imperial
College-Cambridge University-Manchester University (ICCAM) addiction
cluster (G1000018).This is the final version of the article. It first appeared from Springer at http://dx.doi.org/10.1007/s00213-016-4405-8
The cellular microscopy phenotype ontology
BACKGROUND:
Phenotypic data derived from high content screening is currently annotated using free-text, thus preventing the integration of independent datasets, including those generated in different biological domains, such as cell lines, mouse and human tissues.
DESCRIPTION:
We present the Cellular Microscopy Phenotype Ontology (CMPO), a species neutral ontology for describing phenotypic observations relating to the whole cell, cellular components, cellular processes and cell populations. CMPO is compatible with related ontology efforts, allowing for future cross-species integration of phenotypic data. CMPO was developed following a curator-driven approach where phenotype data were annotated by expert biologists following the Entity-Quality (EQ) pattern. These EQs were subsequently transformed into new CMPO terms following an established post composition process.
CONCLUSION:
CMPO is currently being utilized to annotate phenotypes associated with high content screening datasets stored in several image repositories including the Image Data Repository (IDR), MitoSys project database and the Cellular Phenotype Database to facilitate data browsing and discoverability
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