Technology Challenge

The 1998 MTTA Technology ChallengeThe MTTA (The Machine Tool Technologies Association) Technology Challenge featured 37 schools and partner companies working together on manufacturing-based projects throughout the year. Each school teamed up with a local company to work on the Challenge, starting off their projects with industrial visits. The children that took part in the Challenge were aged between 8-11 years, the aim being to excite the younger generation about the opportunities available to them in engineering. MTTA supports the view that it is important to ensure that teachers have the knowledge to further inspire and nurture the children's interest. Teacher training days are organised to assist this, enabling teachers to experience the importance of engineering skills to industry

Reviews

The following publications have been reviewed by the mentioned authors;Textile Innovation - reviewed by Helen WilsonTransferring Designs to Textiles - reviewed by Helen WilsonFood Solutions - reviewed by Jonty KinsellaICT Activities for Food Technology - reviewed by Jenny JupeGCSE Food Technology for OCR - reviewed by Karen O'MahonyFocus on Wood Joints - reviewed by Alison HardyDesigning for the future - reviewed by Ian CapewellLearning to Teach Design and Technology in the Secondary School - reviewed by Jenny JupeUnlocking Potential - reviewed by Rowland DyeThe E-learning Revolution - reviewed by Les Porte

Reviews

The following publications have been reviewed by the mentioned authors;The Story of the Can - reviewed by Marion RutlandExploring Food Cans - reviewed by Marion RutlandJames Dyson: Against the Odds - reviewed by David SpendloveDesign and Make It! Key Stage 3 Assessment Resources: Product Design and Food and Textiles - reviewed by Ali FarrellIn Target Design and Technology Key Stage 3 - reviewed by Ali FarrellThe Chocolate Challenge - reviewed by Anne RiggsFocus on Design Technology: Resistant Materials - reviewed by Chris SnellThe Food File - reviewed by Melanie FasciatoThe Usbourne Complete Book of the Internet and the World Wide Web - reviewed by Alan CrossTechno Designers - reviewed by Jenny JupeBasic Food Hygiene Interactive CD-ROM - reviewed by Jenny JupeThe University of Greenwich D&T Resource Materials - reviewed by Michael Lawranc

Reviews

The following publications have been reviewed by the mentioned authors;Technology Education - A World Wide Concern - reviewed by Dr Thomas GinnerLiving Materials - Practical Activities in Science and Technology - reviewed by David FosterSTEP Design and Technology: Resistant Materials - reviewed by Les PorterSTEP Design and Technology: Food - reviewed by Jenny JupeTERU Diagnostic Tests in Design and Technology - reviewed by Bill GoddardUnderstanding Practice in Design and Technology - reviewed by Melanie FasciatoTeaching Design and Technology - reviewed by John HillD&T Alive at Alton Towers Key Stage 3 - reviewed by John DurrellSucceeding with Autocad - reviewed by P WhittakerTIckle the Senses! - reviewed by Ali FarrellThe Fast Food Diner - reviewed by Margaret Jepso

Reviews

The following publications have been reviewed by the mentioned authors;Design and Technology Frames - reviewed by Mark HudsonDiscoveries - reviewed by Melanie FasciatoProgressio in Primary Design and Technology - reviewed by Rob BowenPrimary Design and Technology: Introducing Birds and Conservation to the Curriculum - reviewed by Bridget A. EganFood Tables and Labelling - reviewed by Jonty KinsellaExploring Materials CD-ROM Education Pack - reviewed by Chris SnellSkills in Resistant Materials Technology - reviewed by Mark HudsonDo3D - reviewed by Les PorterDesign and Technology Textiles Foundation Course - reviewed by Helen WilsonFocus on Plastics - reviewed by Chris SnellUnderstanding Industrial Practices in Textiles Technology - reviewed by Jenny JupeDyson Education Box - reviewed by Jenny JupeEdison 3.0 - reviewed by Jean Allma

Reviews

The following publications have been reviewed by the mentioned authors;Technology Education for Teachers - reviewed by Bill GoddardUnderstanding Design and Technology Key Stage 2 & 3 - reviewed by Melanie FasciatoElectronics Tasks and Assignments - reviewed by Trevor TaylorOutline Scheme of Work 'Working towards Capability' - reviewed by Bill GoddardCADpius - reviewed by Les PorterTechnology 1 - reviewed by Richard AgerDigital Electronics - reviewed by David FosterAn Introduction to Usability - reviewed by Anne RiggsHow do they do that? - reviewed by Jonty KinsellaD & T Routes: Graphic Products - reviewed by George AsquithD & T Routes: Textiles - reviewed by Jillian MellorD & T Routes: Resistant Materials - reviewed by Chris SnellD & T Routes: Food - reviewed by Margaret JepsonD & T Routes: Control Products - reviewed by Chris WoodD & T Routes: Core Book - reviewed by Jenny JupeD & T Routes: Teacher's Resource - reviewed by Jenny Jup

Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities

The assumption that RNA can be readily classified into either protein-coding or non-protein–coding categories has pervaded biology for close to 50 years. Until recently, discrimination between these two categories was relatively straightforward: most transcripts were clearly identifiable as protein-coding messenger RNAs (mRNAs), and readily distinguished from the small number of well-characterized non-protein–coding RNAs (ncRNAs), such as transfer, ribosomal, and spliceosomal RNAs. Recent genome-wide studies have revealed the existence of thousands of noncoding transcripts, whose function and significance are unclear. The discovery of this hidden transcriptome and the implicit challenge it presents to our understanding of the expression and regulation of genetic information has made the need to distinguish between mRNAs and ncRNAs both more pressing and more complicated. In this Review, we consider the diverse strategies employed to discriminate between protein-coding and noncoding transcripts and the fundamental difficulties that are inherent in what may superficially appear to be a simple problem. Misannotations can also run in both directions: some ncRNAs may actually encode peptides, and some of those currently thought to do so may not. Moreover, recent studies have shown that some RNAs can function both as mRNAs and intrinsically as functional ncRNAs, which may be a relatively widespread phenomenon. We conclude that it is difficult to annotate an RNA unequivocally as protein-coding or noncoding, with overlapping protein-coding and noncoding transcripts further confounding this distinction. In addition, the finding that some transcripts can function both intrinsically at the RNA level and to encode proteins suggests a false dichotomy between mRNAs and ncRNAs. Therefore, the functionality of any transcript at the RNA level should not be discounted

The Genetic Signatures of Noncoding RNAs

The majority of the genome in animals and plants is transcribed in a developmentally regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose incidence increases with developmental complexity. There is growing evidence that these transcripts are functional, particularly in the regulation of epigenetic processes, leading to the suggestion that they compose a hitherto hidden layer of genomic programming in humans and other complex organisms. However, to date, very few have been identified in genetic screens. Here I show that this is explicable by an historic emphasis, both phenotypically and technically, on mutations in protein-coding sequences, and by presumptions about the nature of regulatory mutations. Most variations in regulatory sequences produce relatively subtle phenotypic changes, in contrast to mutations in protein-coding sequences that frequently cause catastrophic component failure. Until recently, most mapping projects have focused on protein-coding sequences, and the limited number of identified regulatory mutations have been interpreted as affecting conventional cis-acting promoter and enhancer elements, although these regions are often themselves transcribed. Moreover, ncRNA-directed regulatory circuits underpin most, if not all, complex genetic phenomena in eukaryotes, including RNA interference-related processes such as transcriptional and post-transcriptional gene silencing, position effect variegation, hybrid dysgenesis, chromosome dosage compensation, parental imprinting and allelic exclusion, paramutation, and possibly transvection and transinduction. The next frontier is the identification and functional characterization of the myriad sequence variations that influence quantitative traits, disease susceptibility, and other complex characteristics, which are being shown by genome-wide association studies to lie mostly in noncoding, presumably regulatory, regions. There is every possibility that many of these variations will alter the interactions between regulatory RNAs and their targets, a prospect that should be borne in mind in future functional analyses