52 research outputs found
First-Principles Investigation of Anistropic Hole Mobilities in Organic Semiconductors
We report a simple first-principles-based simulation model (combining quantum mechanics with MarcusâHush theory) that provides the quantitative structural relationships between angular resolution anisotropic hole mobility and molecular structures and packing. We validate that this model correctly predicts the anisotropic hole mobilities of ruberene, pentacene, tetracene, 5,11-dichlorotetracene (DCT), and hexathiapentacene (HTP), leading to results in good agreement with experiment
Clue-based Spatio-textual Query
Along with the proliferation of online digital map and location-based service, very large POI (point of interest) databases have been constructed where a record corresponds to a POI with information including name, category, address, geographical location and other features. A basic spatial query in POI database is POI retrieval. In many scenarios, a user cannot provide enough information to pinpoint the POI except some
clue.
For example, a user wants to identify a caf
Ă©
in a city visited many years ago. SHe cannot remember the name and address but she still recalls that "the caf
Ă©
is about 200 meters away from a restaurant; and turning left at the restaurant there is a bakery 500 meters away, etc.". Intuitively, the clue, even partial and approximate, describes the spatio-textual context around the targeted POI. Motivated by this observation, this work investigates
clue-based spatio-textual query
which allows user providing clue, i.e., some nearby POIs and the spatial relationships between them, in POI retrieval. The objective is to retrieve
k
POIs from a POI database with the highest spatio-textual context similarities against the clue. This work has deliberately designed data-quality-tolerant spatio-textual context similarity metric to cope with various data quality problems in both the clue and the POI database. Through crossing valuation, the query accuracy is further enhanced by
ensemble method.
Also, this work has developed an index called
roll-out-star R-tree
(RSR-tree) to dramatically improve the query processing efficiency. The extensive tests on data sets from the real world have verified the superiority of our methods in all aspects.
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Laboratory-based Surveillance of Extensively Drug-Resistant Tuberculosis, China
To estimate the prevalence of extensively drug-resistant tuberculosis (XDR TB) in China, we retrospectively analyzed drug-resistance profiles of 989 clinical Mycobacterium tuberculosis isolates. We found 319 (32.3%) isolates resistant to >1 first-line drugs; 107 (10.8%) isolates were multidrug resistant, of which 20 (18.7%) were XDR. XDR TB is of major concern in China
Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history
<p>Abstract</p> <p>Background</p> <p>A2143G mutation of <it>23S rRNA </it>gene of <it>H. pylori </it>results in clarithromycin (CLR) resistance. To investigate the prevalence of the CLR resistance-related A2143G mutation of the <it>H. pylori</it>-specific <it>23S rRNA </it>gene in Chinese subjects with and without CLR use history, 307 subjects received the treatment with amoxicillin and omeprazole (OA) and 310 subjects received a placebo in 1995, and 153 subjects received a triple therapy with OA and CLR (OAC) in 2000. DNA was extracted from fasting gastric juice at the end of the intervention trial in 2003. <it>H. pylori </it>infection was determined by <it>H. pylori</it>-specific <it>23S rRNA </it>PCR, ELISA, and<sup>13</sup>C-urea breath test assays. Mutations of the <it>23S rRNA </it>gene were detected by RFLP assays.</p> <p>Results</p> <p>The presence of <it>23S rRNA </it>due to <it>H. pylori </it>infection in the OA group remained lower than that in the placebo group 7.3 yrs after OA-therapy [51.1% (157/307) vs. 83.9% (260/310), p = 0.0000]. In the OAC group, the <it>23S rRNA </it>detection rate was 26.8% (41/153) three yrs after OAC-treatment. The A2143G mutation rate among the <it>23S rRNA</it>-positive subjects in the OAC group [31.7% (13/41)] was significantly higher than that in the OA group [10.2% (16/157)] and the placebo group [13.8% (36/260)]. The frequency of the AAGGG â CTTCA (2222â2226) and AACC â GAAG (2081â2084) sequence alterations in the OAC group was also significantly higher than those in the OA group and the placebo group.</p> <p>Conclusion</p> <p>Primary prevalence of the A2143G mutation was 10~14% among Chinese population without history of CLR therapy. Administration of CLR to eliminate <it>H. pylori </it>infection increased the prevalence of the A2143G mutation in Chinese subjects (32%) significantly.</p
Identification of three species commonly known as âdaqingyeâ by internal leaf anatomy and high-performance liquid chromatography analyses
The macroscopic and microscopic morphologies and indigo and indirubin concentration of the traditional Chinese medicine herbs Isatis indigotica Fort., Polygonum tinctorium Ait., and Baphicacanthus cusia (Nees) Bremek, all commonly known as âdaqingyeâ, were determined and compared. The morphological analyses indicated that I. indigotica has leaves with winged petioles and no glandular hairs or crystals, P. tinctorium has leaves with membranous ocrea and clusters of calcium oxalate, and B. cusia has palisade cells in the mesophyll running over the main vein and single cells containing calcium carbonate crystals. Indigo and indirubin are chemical constituents that have been previously isolated from daqingye and were selected in this study as identification markers for high-performance liquid chromatography analysis due to their pharmacological activities. The chromatographic results showed that indigo and indirubin concentration varied significantly among the three species: high concentration of both indigo and indirubin were observed in I. indigotica, the highest concentration among the three daqingye plants was found in P. tinctorium but with low levels of indirubin, and the concentration of indigo and indirubin was quite low in B. cusia. In summary, three different species commonly known as daqingye were accurately distinguished by morphological observation, internal leaf anatomy analysis, and chromatographic analysis
Analyzing the Chinese landscape in anti-diabetic drug research: leading knowledge production institutions and thematic communities
Matching stream patterns of various lengths and tolerances
Continuously identifying pre-defined patterns in a streaming time series has strong demand in various applications. While most existing works assume the patterns are in equal length and tolerance, this work focuses on the problem where the patterns have various lengths and tolerances, a common situation in the real world. The challenge of this problem roots on the strict space and time requirements of processing the arriving and expiring data in high-speed stream, combined with difficulty of coping with a large number of patterns with various lengths and tolerances. We introduce a novel concept of converging envelope which bounds the tolerance of a group of patterns in various tolerances and equal length and thus dramatically reduces the number of patterns for similarity computation. The basic idea of converging envelope has potential to more general index problems. To index patterns in various lengths and tolerances, we partition patterns into sub-patterns in equal length and an multi-tree index is developed in this paper. Copyright 2009 ACM
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