Analysis of significant protein abundance from multiple reaction-monitoring data

Background Discovering reliable protein biomarkers is one of the most important issues in biomedical research. The ELISA is a traditional technique for accurate quantitation of well-known proteins. Recently, the multiple reaction-monitoring (MRM) mass spectrometry has been proposed for quantifying newly discovered protein and has become a popular alternative to ELISA. For the MRM data analysis, linear mixed modeling (LMM) has been used to analyze MRM data. MSstats is one of the most widely used tools for MRM data analysis that is based on the LMMs. However, LMMs often provide various significance results, depending on model specification. Sometimes it would be difficult to specify a correct LMM method for the analysis of MRM data. Here, we propose a new logistic regression-based method for Significance Analysis of Multiple Reaction Monitoring (LR-SAM). Results Through simulation studies, we demonstrate that LMM methods may not preserve type I error, thus yielding high false- positive errors, depending on how random effects are specified. Our simulation study also shows that the LR-SAM approach performs similarly well as LMM approaches, in most cases. However, LR-SAM performs better than the LMMs, particularly when the effects sizes of peptides from the same protein are heterogeneous. Our proposed method was applied to MRM data for identification of proteins associated with clinical responses of treatment of 115 hepatocellular carcinoma (HCC) patients with the tyrosine kinase inhibitor sorafenib. Of 124 candidate proteins, LMM approaches provided 6 results varying in significance, while LR-SAM, by contrast, yielded 18 significant results that were quite reproducibly consistent. Conclusion As exemplified by an application to HCC data set, LR-SAM more effectively identified proteins associated with clinical responses of treatment than LMM did.This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C2037, HI15C2165). Publication of this article was sponsored by HI16C2037 grant

A Framework for Integration of Knowledge Management and Business Process Management

Recently, several attempts have been made to introduce the process concept to knowledge management (KM) or the knowledge concept to business process management (BPM) in order to combine the advantages of the two approaches. However, clear description about their interrelationship or a comprehensive framework to combine them has not been provided. This paper explores how KM and BPM can complement each other and proposes a framework to integrate the two paradigms. The concept of process knowledge proposed by this paper focuses on the importance of business processes as knowledge, which is overlooked by existing KM or BPM research efforts. The paper proposes a framework that combines and extends the functionalities of existing knowledge management systems (KMSs) and business process management systems (BPMSs) by identifying the functionalities required to manage process knowledge from the lifecycle perspective of both knowledge management and business process management. A prototype system is also presented to demonstrate the feasibility of the proposed framework.clos

AN INTEGRATED FRAMEWORK FOR PROCESS KNOWLEDGE MANAGEMENT

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An integration architecture for knowledge management systems and business process management systems

Recently, interests in the notion of process-oriented knowledge management (PKM) from academia and industry have been significantly increased. Comprehensive research and development requirements along with a cogent framework, however, have not been proposed for integrating knowledge management (KM) and business process management (BPM), which were proposed independently. Based on a comprehensive framework that reflects lifecycle requirements of both KM and BPM, this paper proposes an architecture for integrating knowledge management systems (KMSs) and business process management systems (BPMSs) to combine the advantages of the two paradigms. The paper first defines the concept of process knowledge and classifies it into three types. Then, it suggests how the functionalities of existing KMSs and BPMSs must be extended to support the three types of process knowledge while satisfying the lifecycle requirements of both knowledge and business processes. The architecture, which is comprehensive since it is derived from the extended requirements from the lifecycle perspective, will provide a basis for research and development of process-oriented knowledge management systems. A prototype system is presented to demonstrate the feasibility of the proposed architecture.close286

ABSTRACT

Compensation is widely used in advanced transaction models as a means of backward recovery from a failure. However, traditional compensation notions are not sufficient for handling failures in business processes if state changes involve consumable resources that cannot be undone. This paper presents a backward recovery mechanism to support the business process management domain. The proposed mechanism resets a business process to an acceptable state by re-executing all or a part of its activities that are failed or already completed successfully. The paper classifies backward recovery types into compensation, rework, and complementation, and discusses their semantics. Then, the paper classifies the types of process activities based on resource constraints. By exploiting the meaning of activity types and backward recovery types, the paper presents guidelines that determine if a business process can be restored to an acceptable state

A Backward Recovery Mechanism for Workflow Management (Extended Abstract)

Compensation is widely used in advanced transaction models as a means of backward recovery from a failure. However, traditional compensation notions are not sufficient for handling failures in business processes if state changes involve consumable resources that cannot be undone. This paper presents a backward recovery mechanism to support the business process management domain. The proposed mechanism resets a business process to an acceptable state by re-executing all or a part of its activities that are failed or already completed successfully. The paper classifies backward recovery types into compensate, rework, and complement, and discusses their semantics. Then, the paper classifies the types of process activities based on resource constraints. By exploiting the meaning of activity types and backward recovery types, the paper presents guidelines that determine if a business process can be restored to an acceptable state

비뉴턴 유체를 이용한 스마트 과속방지턱 소재 개발

In this study, a smart material applicable to speed bumps was developed using low-cost starch and water-based suspensions, and their properties were investigated. Viscosity and shear stress according to the shear rate was measured by a rheometer to observe shear thickening behavior according to starch concentration. The shear thickening phenomenon and applicability to speed bumps were identified macroscopically via drop weight test and bike driving test, measuring the vibration after impact with a driving speed of 5-25 km/h. As a result of the viscosity measurement, shear thickening occurred after the shear thinning region at the beginning, and the critical strain causing the shear thickening phenomenon decreased as the concentration of starch increased. Also, the viscosity and shear stress increased significantly with the increase of the starch concentration. As a result of the drop weight test and the bike driving test, the suspension was changed to a solid-like state in a short time, and the impact energy was absorbed in the fluid. The shear thickening phenomenon easily occurred as the concentration of the fluid and the applied impact (velocity) increased. Therefore, it can be proposed the development of a smart speed bump material that operates in the range of 5-25 km/h with a Non-Newtonian fluid based on water and starch.N

The Study on a Cooperative Education System for Logistics: the Case Study of International Program in Logistics Management Systems in Technology University of Eindhoven

Korea needs to build world-class infrastructures that will shape the country into the logistics hub of the Northeast Asia. To achieve the goal, highly skilled and internationalized experts in the area of logistics are required. In Korea, however, there are no education programs that train qualified experts who have not only knowledge in logistics but also industrial and international experiences. This paper introduces a case study on education programs which cultivate such experts. An in-depth analysis was conducted on the global logistics program of Technical University of Eindhoven (TU/e) in the Netherlands. The global logistics program of TU/e is an international post master program in which several universities as well as famous companies such as Philips, Nokia, etc. are tightly involved. We analyzed the success factors of this program by investigating the roles of university, social community, and industry. Based on these success factors, some suggestions are made for establishing competitive logistics education programs in Korea.clos

Low-Temperature and High-Quality Growth of Bi2O2 Se Layered Semiconductors via Cracking Metal-Organic Chemical Vapor Deposition

Ternary metal-oxy-chalcogenides are emerging as next-generation layered semiconductors beyond binary metal-chalcogenides (i.e., MoS2). Among ternary metal-oxy-chalcogenides, especially Bi2O2Se has been demonstrated in field-effect transistors and photodetectors, exhibiting ultrahigh performance with robust air stability. The growth method for Bi2O2Se that has been reported so far is a powder sublimation based chemical vapor deposition. The first step for pursuing the practical application of Bi2O2Se as a semiconductor material is developing a gas-phase growth process. Here, we report a cracking metal-organic chemical vapor deposition (c-MOCVD) for the gas-phase growth of Bi2O2Se. The resulting Bi2O2Se films at very low growth temperature (similar to 300 degrees C) show single-crystalline quality. By taking advantage of the gas-phase growth, the precise phase control was demonstrated by modulating the partial pressure of each precursor. In addition, c-MOCVD-grown Bi2O2Se exhibits outstanding electrical and optoelectronic performance at room temperature without passivation, including maximum electron mobility of 127 cm(2)/(V.s) and photoresponsivity of 45134 A/W