The Impact of a Flipped Classroom on Student Achievement in Mathematics, Science and Physical Education Classrooms

This study was designed to examine the effects of the flipped classroom model. Our study was conducted in Physical Education, Mathematics, and Science classrooms in the Bismarck Public Schools district. The participants were in both the middle and high school levels within the same school district. Data collection methods included a pre-assessment survey, written assignments, a student behavior checklist, and a post-assessment survey. The results of our study showed that students enjoyed learning with the flipped classroom method, completion rates were higher than previously observed, and students were successful at mastering classroom content. According to our student survey, the main benefits to the flipped classroom, were the ability to view lessons without distractions and to view them multiple times. We will continue to look into the benefits of the flipped classroom through the analysis of standardized test scores and classroom assessments

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and chondrosarcoma (CS). For AML, low-grade glioma and CC, mutant IDH status is associated with a DNA hypermethylation phenotype, implicating altered epigenome dynamics in the aetiology of these cancers. Here we show that the IDH variants in CS are also associated with a hypermethylation phenotype and display increased production of the oncometabolite 2-hydroxyglutarate, supporting the role of mutant IDH-produced 2-hydroxyglutarate as an inhibitor of TET-mediated DNA demethylation. Meta-analysis of the acute myeloid leukaemia, low-grade glioma, cholangiocarcinoma and CS methylation data identifies cancer-specific effectors within the retinoic acid receptor activation pathway among the hypermethylated targets. By analysing sequence motifs surrounding hypermethylated sites across the four cancer types, and using chromatin immunoprecipitation and western blotting, we identify the transcription factor EBF1 (early B-cell factor 1) as an interaction partner for TET2, suggesting a sequence-specific mechanism for regulating DNA methylation