The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury

Angiotensin II (AngII) causes hypertension (HTN) and promotes renal injury while simultaneously inducing reno-protective enzymes like heme oxygenase-1 (HO-1). We examined the modulatory role of HO on sub-pressor angiotensin II (SP-AngII) induced renal inflammation and injury. We first tested whether the SP-AngII-induced renal dysfunction, inflammation and injury are exacerbated by either preventing (chronic HO-1 inhibition) or reversing (late HO-1 inhibition) SP-AngII-induced HO (using tin protoporphyrin; SnPP). We next examined whether additional chronic or late induction of SP-AngII-induced HO (using cobalt protoporphyrin; CoPP), prevents or ameliorates renal damage. We found that neither chronic nor late SnPP altered blood pressure. Chronic SnPP worsened SP-AngII-induced renal dysfunction, inflammation, injury and fibrosis, whereas late SnPP worsened renal dysfunction but not inflammation. Chronic CoPP prevented HTN, renal dysfunction, inflammation and fibrosis, but surprisingly, not the NGAL levels (renal injury marker). Late CoPP did not significantly alter SP-AngII-induced HTN, renal inflammation or injury, but improved renal function. Thus, we conclude (a) endogenous HO may be an essential determining factor in SP-AngII induced renal inflammation, injury and fibrosis, (b) part of HO's renoprotection may be independent of blood pressure changes; and (c) further induction of HO-1 protects against renal injury, suggesting a possible therapeutic target

Resilience as an emergent European project? The EU’s place in the resilience turn

This article looks at the development of the resilience approach in EU foreign policy. Building state and societal resilience in the EU's neighbourhood has been identified as one of the key priorities in the EU global strategy. Here we critically analyse these developments and seek to provide an account of the complex dynamics within which the EU's approach to resilience is located. We argue that EU resilience‐thinking is influenced by three broad dynamics – the neoliberal and Anglo‐Saxon approaches to resilience in the sphere of global governance; the particular normative discourse of the EU as a certain type of global actor (the EU as a normative/liberal power); and the multilevel character of the EU with its complex institutional structure and path dependencies which results in decoupling. As a consequence, the ‘translation’ of resilience constitutes an emergent project at the EU level, but also brings with it new challenges. The argument will be illustrated through a study of the EU global strategy and the Joint Communication on resilience in the neighbourhood

Temporal characteristics of speech: The effect of age and speech style

Aging affects temporal characteristics of speech. It is still a question how these changes occur in different speech styles which require various cognitive skills. In this paper speech rate, articulation rate, and pauses of 20 young and 20 old speakers are analyzed in four speech tyles: spontaneous narrative, narrative recalls, a three-participant conversation, and reading aloud. Results show that age has a significant effect only on speech rate, articulation rate, and frequency of pauses. Speech style has a higher effect on temporal parameters than speakers’ age

Possible Treatment of Parkinson's Disease with Intrathecal Medication in the MPTP Model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73916/1/j.1749-6632.1988.tb31828.x.pd

A cross-cultural, participatory approach for measuring and cultivating resilience on small and medium farms

One of the greatest leverage points in fostering the transition to sustainability can be found in the realm of food systems. The COVID-19 pandemic has brought into sharp focus the critical importance of small farm resilience to the well-being of communities around the world. We explored the role of small and medium farms in promoting sustainable social-agricultural systems, and investigated how the resilience of these farms can be both measured and amplified. W e integrated concepts from the fields of food systems sustainability and resilience, agroecology, and positive deviance to identify indicators that can help measure and track farm resilience. Our aims were to 1) investigate the diversity of ecological and social factors that impact the vulnerability, resilience, and long-term health of small-medium farms and farm systems, exploring similarities and differences between the two cultures/geographies; 2) incorporate farmers’ personal experiences together with knowledge in the academic literature to enrich understanding about food systems sustainability; and 3) develop an indicator tool for evaluating farm resilience that empowers farmers to both assess their local farm system and to implement and document change over time. Our research process employed a cross-cultural, mixed-methods, Participatory Action Research (PAR) approach that engaged farmers from diverse geographic settings in Puerto Rico and Vermont. The project was organized into four phases implemented over a six month period from July through December 2020. These included identifying farmer participants, selecting key farm resilience frameworks, distilling a preliminary list of indicators, and validating those indicators with farmer feedback through surveys, interviews, and group meetings. The phases culminated in the creation of a Farm Resilience Tool for conducting rapid assessments using 20 indicators organized into four categories of Growth Mindset, Strong Relationships, Sustainable Farming Practices, and Sustainable Business Management. We further outlined a proposal for how to implement and refine the tool with farmer participants through subsequent PAR activities. Refinement is essential, given that our proposal is place-based and local, yet also modular and globally scalable to help advance planetary sustainability. More research is necessary to understand potential tradeoffs and synergies that can occur from trying to optimize multiple outcomes in tandem, and how to transition small farm resilience to broader-scale landscape planning and management strategies. Among the important lessons learned from this project are A) the importance of farmer-to-farmer knowledge sharing, B) the value of an authentic and reciprocal PAR process in expanding the range and depth of understanding beyond the academic literature, C) the utility of integrating positive deviants for helping identify indicators and examples of resilience outside the box of traditional thinking, and D) the rich interaction across cultures and geographies that enlivens the research and enlightens the outcomes. All these lessons converge on the critical insight that sustainability is ultimately about the quality of relationships within food systems. Thus, food systems research must integrate objective and subjective methods in order to cultivate the relational synergy needed to address and transcend the complex problems we face in the 21st Century

Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence of hypertension. NZBWF1 (SLE-Hyp) mice develop hypertension that can be prevented by modulating T cells. The peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) decreases renal damage and improves renal function in a model of SLE without hypertension (MRL/lpr). However, it is not known whether Ac-SDKP prevents hypertension in NZBWF1 mice. We hypothesized that in SLE-Hyp, Ac-SDKP prevents hypertension and renal damage by modulating T cells. Animals were divided into four groups: (1) control + vehicle, (2) control + Ac-SDKP, (3) SLE + vehicle, and (4) SLE + Ac-SDKP Systolic blood pressure (SBP), albuminuria, renal fibrosis, and T-cell phenotype were analyzed. SBP was higher in SLE compared to control mice and was not decreased by Ac-SDKP treatment. Half of SLE mice developed an acute and severe form of hypertension accompanied by albuminuria followed by death. Ac-SDKP delayed development of severe hypertension, albuminuria, and early mortality, but this delay did not reach statistical significance. Ac-SDKP prevented glomerulosclerosis, but not interstitial fibrosis in SLE-Hyp mice. SLE-Hyp mice showed a decrease in helper and cytotoxic T cells as well as an increase in double negative lymphocytes and T helper 17 cells, but these cells were unaffected by Ac-SDKP In conclusion, Ac-SDKP prevents kidney damage, without affecting blood pressure in an SLE animal model. However, during the acute relapse of SLE, Ac-SDKP might also delay the manifestation of an acute and severe form of hypertension leading to early mortality. Ac-SDKP is a potential tool to treat renal damage in SLE-Hyp mice

Amplifying Agroecology in Vermont: Principles and Processes to Foster Food Systems Sustainability

Agroecology is grounded in principles that support transitions toward economic, social and ecological sustainability and proposes that real and lasting change will require a significant transformation of our agri-food systems. Evidence for agroecology’s potential continues to grow, both through word of mouth by farmers and social movements, and through recent scientific assessments of its performance. With endorsements from the Food & Agriculture Organization of the United Nations (FAO), national governments in both the global north and south, and social movements, it is developing the web of ‘thick legitimacy’ required for even broader adoption (Montenegro de Wit & Iles, 2016). “...Agroecology represents a system that works with nature instead of against it and offers an approach to food production that boosts biodiversity, creates ecological resilience, improves soils, cools the planet and reduces energy and resource use. It has been shown to be highly productive, to provide highly diverse dietary offerings and to support the process of community building and women’s empowerment” (Anderson et al., 2020, p. 3). However, agroecology is an approach that is not yet recognized as being actively practiced in Vermont and the USA, despite its significant potential for supporting transitions to sustainable food systems in different contexts. The University of Vermont is home to researchers and practitioners at the forefront of agroecological research and learning. The objectives of this white paper are to demonstrate the importance of agroecology for the future of sustainable food systems in Vermont, and as a framework to assess and advance transformations towards sustainability. In this paper we will: a) Demonstrate the global evidence base for agroecology and the potential of agroecology in the United States, and Vermont. b) Present the case for an agroecological principles-based approach to assess food and farming sustainability which can capture the multifunctional dynamics and benefits of agroecology to economic, social and ecological sustainability. c) Present examples based on our newly developed Agroecological Assessment for Sustainability framework to existing initiatives in Vermont that represent constituencies across a range of farm types and scales. d) Demonstrate the importance of participatory and transdisciplinary approaches for researc