2,203 research outputs found
The leptonic decay using the principle of maximum conformality
In the paper, we study the leptonic decay width
by using the principle of maximum
conformality (PMC) scale-setting approach. The PMC adopts the renormalization
group equation to set the correct momentum flow of the process, whose value is
independent to the choice of the renormalization scale and its prediction thus
avoids the conventional renormalization scale ambiguities. Using the known
next-to-next-to-next-to-leading order perturbative series together with the PMC
single scale-setting approach, we do obtain a renormalization scale independent
decay width, keV,
where the error is squared average of those from
, GeV and the choices of
factorization scales within of their central values. To compare with
the result under conventional scale-setting approach, this decay width agrees
with the experimental value within errors, indicating the importance of a
proper scale-setting approach.Comment: 6 pages, 4 figure
Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis
Tissue fibrosis compromises organ function and occurs as a potential
long-term outcome in response to acute tissue injuries. Currently, lack of
mechanistic understanding prevents effective prevention and treatment of the
progression from acute injury to fibrosis. Here, we combined quantitative
experimental studies with a mouse kidney injury model and a computational
approach to determine how the physiological consequences are determined by the
severity of ischemia injury, and to identify how to manipulate Wnt signaling to
accelerate repair of ischemic tissue damage while minimizing fibrosis. The
study reveals that Wnt-mediated memory of prior injury contributes to fibrosis
progression, and ischemic preconditioning reduces the risk of death but
increases the risk of fibrosis. Furthermore, we validated the prediction that
sequential combination therapy of initial treatment with a Wnt agonist followed
by treatment with a Wnt antagonist can reduce both the risk of death and
fibrosis in response to acute injuries
Methyl 2-[2-(tert-butÂoxyÂcarbonylÂamino)-1,3-benzothiaÂzole-6-carboxamido]Âacetate
In the title compound, C16H19N3O5S, the dihedral angle between the benzene ring and the carbonylÂamino group is 18.18 (2)°. In the crystal, molÂecules form centrosymmetric dimers via pairs of N—H⋯N hydrogen bonds. The dimers are connected via N—H⋯O hydrogen bonds into a three-dimensional network.
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