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Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
The substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) contain the two largest populations of dopamine (DA)-releasing neurons in the mammalian brain. These neurons extend elaborate projections in striatum, a large subcortical structure implicated in motor planning and reward-based learning. Phasic activation of dopaminergic neurons in response to salient or reward-predicting stimuli is thought to modulate striatal output via the release of DA to promote and reinforce motor action1–4. Here we show that activation of DA neurons in striatal slices rapidly inhibits action potential firing in both direct-and indirect-pathway striatal projection neurons (SPNs) through vesicular release of the inhibitory transmitter γ-aminobutyric acid (GABA). GABA is released directly from dopaminergic axons but in a manner that is independent of the vesicular GABA transporter VGAT. Instead GABA release requires activity of the vesicular monoamine transporter VMAT2, which is the vesicular transporter for DA. Furthermore, VMAT2 expression in GABAergic neurons lacking VGAT is sufficient to sustain GABA release. Thus, these findings expand the repertoire of synaptic mechanisms employed by DA neurons to influence basal ganglia circuits, reveal a novel substrate whose transport is dependent on VMAT2, and demonstrate that GABA can function as a bona fide co-transmitter in monoaminergic neurons
Proton-Antiproton Annihilation in Baryonium
A possible interpretation of the near-threshold enhancement in the
-mass spectrum in is the of existence
of a narrow baryonium resonance X(1860). Mesonic decays of the
-bound state X(1860) due to the nucleon-antinucleon annihilation
are investigated in this paper. Mesonic coherent states with fixed -parity
and -parity have been constructed . The Amado-Cannata-Dedoder-Locher-Shao
formulation(Phys Rev Lett. {\bf 72}, 970 (1994)) is extended to the decays of
the X(1860). By this method, the branch-fraction ratios of , and are calculated. It is shown
that if the X(1860) is a bound state of , the decay channel ( is favored over . In this way, we develop
criteria for distinguishing the baryonium interpretation for the near-threshold
enhancement effects in -mass spectrum in from other possibilities. Experimental checks are expected. An intuitive
picture for our results is discussed.Comment: 19 pages, 3 figure
Rotational Symmetry of Classical Orbits, Arbitrary Quantization of Angular Momentum and the Role of Gauge Field in Two-Dimensional Space
We study the quantum-classical correspondence in terms of coherent wave
functions of a charged particle in two-dimensional central-scalar-potentials as
well as the gauge field of a magnetic flux in the sense that the probability
clouds of wave functions are well localized on classical orbits. For both
closed and open classical orbits, the non-integer angular-momentum quantization
with the level-space of angular momentum being greater or less than is
determined uniquely by the same rotational symmetry of classical orbits and
probability clouds of coherent wave functions, which is not necessarily
-periodic. The gauge potential of a magnetic flux impenetrable to the
particle cannot change the quantization rule but is able to shift the spectrum
of canonical angular momentum by a flux-dependent value, which results in a
common topological phase for all wave functions in the given model. The quantum
mechanical model of anyon proposed by Wilczek (Phys. Rev. Lette. 48, 1144)
becomes a special case of the arbitrary-quantization.Comment: 6 pages, 5 figure
BONE MORPHOGENETIC PROTEIN-2 AND COLLAGEN TYPE 1 FROM DIFFERENT SOURCES OF DEMINERALIZED DENTINE MATRIX: RELEASE KINETIC AND CHEMOTAXIS POTENTIAL FOR OSTEOPROGENITOR CELLS
Objective: To investigate the release of bone morphogenetic protein-2 (BMP-2) and collagen type I proteins (COL1) from different sources ofdemineralized dentine matrix (DDM) and their chemotaxis to mouse osteoprogenitor cells.Methods: The release kinetic of BMP-2 and COL1 was measured from custom-made DDM (CMDDM) and commercially available DDM (CADDM).Using Urist physicochemical method, CMDDM was collected from the extracted teeth in a certified dental clinic. Levels of BMP-2 and COL1 releasedwere measured at days 1, 2, 3, 5, 7, 9, 11, and 13. Next, mouse osteoprogenitor cells, MC3T3-E1, were cultured with a variety of materials as follows:CMDDM, CADDM, Bio-Oss®, and blank control in transwell system. The number of cell migration was determined by crystal violet staining to explorechemotaxis of different DDMs to mouse osteoprogenitor cells.Results: BMP-2 was detected at 588.32 ± 14.53 pg/ml from 5 g of CMDDM. In the release kinetic assay, the concentration of BMP-2 in the CMDDMgroup increased rapidly and peaked at 113.9 pg/ml on day 5, almost four times higher than that of CADDM. The release of COL1 showed similarpattern in both CMDDM and CADDM; however, the amount was significantly higher in the CMDDM group. In cell culture experiment, the number ofmigrated MC3T3-E1 was ranked as the highest in CMDDM, followed by CADDM and Bio-Oss® (p<0.05).Conclusion: CMDDM released BMP-2 and COL1 greater than CADDM, which can induce more osteoblast-like cell migration. These results demonstrateda release kinetic of proteins and osteoinductivity of CMDDM, which supports a benefit of using autogenous bone graft
Free field realization of the exceptional current superalgebra \hat{D(2,1;\a)}_k
The free-field representations of the D(2,1;\a) current superalgebra and
the corresponding energy-momentum tensor are constructed. The related screening
currents of the first kind are also presented.Comment: Latex file, 10 page
A Dnn-Ensemble Method for Error Reduction and Training Data Selection in Dnn based Modeling
Deep neural networks (DNNs) have been widely adopted in modeling electromagnetic compatibility (EMC) problems, but the training data acquisition is usually time-consuming through various simulators. This paper presents a powerful approach using an ensemble of DNN s to effectively reduce the training data size in DNN-based modeling problems. A batch of training data with the largest uncertainties is selected using active learning through the variance among the ensemble of DNNs. Subsequently, a greedy sampling algorithm is applied to select a data subset using diversity. Thus, the proposed method can achieve both uncertainty and diversity in data selection. By averaging the outputs of the DNN ensemble, the prediction error can be further reduced. Simple mathematical functions are used to validate the proposed method, and a high-dimensional strip line modeling problem also demonstrates the effectiveness of this DNN-ensemble approach. The proposed method is task agnostic and can be used in other surrogate modeling problems with DNN s
Symbolic Dynamics Analysis of the Lorenz Equations
Recent progress of symbolic dynamics of one- and especially two-dimensional
maps has enabled us to construct symbolic dynamics for systems of ordinary
differential equations (ODEs). Numerical study under the guidance of symbolic
dynamics is capable to yield global results on chaotic and periodic regimes in
systems of dissipative ODEs which cannot be obtained neither by purely
analytical means nor by numerical work alone. By constructing symbolic dynamics
of 1D and 2D maps from the Poincare sections all unstable periodic orbits up to
a given length at a fixed parameter set may be located and all stable periodic
orbits up to a given length may be found in a wide parameter range. This
knowledge, in turn, tells much about the nature of the chaotic limits. Applied
to the Lorenz equations, this approach has led to a nomenclature, i.e.,
absolute periods and symbolic names, of stable and unstable periodic orbits for
an autonomous system. Symmetry breakings and restorations as well as
coexistence of different regimes are also analyzed by using symbolic dynamics.Comment: 35 pages, LaTeX, 13 Postscript figures, uses psfig.tex. The revision
concerns a bug at the end of hlzfig12.ps which prevented the printing of the
whole .ps file from page 2
Geometry and optics calibration of WFCTA prototype telescopes using star light
The Large High Altitude Air Shower Observatory project is proposed to study
high energy gamma ray astronomy ( 40 GeV-1 PeV ) and cosmic ray physics ( 20
TeV-1 EeV ). The wide field of view Cherenkov telescope array, as a component
of the LHAASO project, will be used to study energy spectrum and compositions
of cosmic ray by measuring the total Cherenkov light generated by air showers
and shower maximum depth. Two prototype telescopes have been in operation since
2008. The pointing accuracy of each telescope is crucial to the direction
reconstruction of the primary particles. On the other hand the primary energy
reconstruction relies on the shape of the Cherenkov image on the camera and the
unrecorded photons due to the imperfect connections between photomultiplier
tubes. UV bright stars are used as point-like objects to calibrate the pointing
and to study the optical properties of the camera, the spot size and the
fractions of unrecorded photons in the insensitive areas of the camera.Comment: 5 pages, 6 figures, submitted to Chinese Physics
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