Genomic Sequence is Highly Predictive of Local Nucleosome Depletion

The regulation of DNA accessibility through nucleosome positioning is important for transcription control. Computational models have been developed to predict genome-wide nucleosome positions from DNA sequences, but these models consider only nucleosome sequences, which may have limited their power. We developed a statistical multi-resolution approach to identify a sequence signature, called the N-score, that distinguishes nucleosome binding DNA from non-nucleosome DNA. This new approach has significantly improved the prediction accuracy. The sequence information is highly predictive for local nucleosome enrichment or depletion, whereas predictions of the exact positions are only modestly more accurate than a null model, suggesting the importance of other regulatory factors in fine-tuning the nucleosome positions. The N-score in promoter regions is negatively correlated with gene expression levels. Regulatory elements are enriched in low N-score regions. While our model is derived from yeast data, the N-score pattern computed from this model agrees well with recent high-resolution protein-binding data in human.Statistic

Advantages of the multinucleon transfer reactions based on 238U target for producing neutron-rich isotopes around N = 126

The mechanism of multinucleon transfer (MNT) reactions for producing neutron-rich heavy nuclei around N = 126 is investigated within two different theoretical frameworks: dinuclear system (DNS) model and isospin-dependent quantum molecular dynamics (IQMD) model. The effects of mass asymmetry relaxation, N=Z equilibration, and shell closures on production cross sections of neutron-rich heavy nuclei are investigated. For the first time, the advantages for producing neutron-rich heavy nuclei around N = 126 is found in MNT reactions based on 238U target. We propose the reactions with 238U target for producing unknown neutron-rich heavy nuclei around N = 126 in the future.Comment: 6 pages, 6 figure