Gas Transport in Porous Media: Simulations and Experiments on Partially Densified Aerogels

The experimental density dependence of gas (argon and nitrogen) permeability of partially densified silica aerogels in the Knudsen regime is quantitatively accounted for by a computer model. The model simulates both the structure of the sintered material and the random ballistic motion of a point particle inside its voids. The same model is also able to account for the densit y dependence of the specific pore surface as measured from nitrogen adsorption experiments.Comment: RevTex, 11 pages + 5 postscript figures appended using "uufiles". Published in Europhys. Lett. 29, p. 567 (1995

Phase diagram of the frustrated spin ladder

We re-visit the phase diagram of the frustrated spin-1/2 ladder with two competing inter-chain antiferromagnetic exchanges, rung coupling J_\perp and diagonal coupling J_\times. We suggest, based on the accurate renormalization group analysis of the low-energy Hamiltonian of the ladder, that marginal inter-chain current-current interaction plays central role in destabilizing previously predicted intermediate columnar dimer phase in the vicinity of classical degeneracy line J_\perp = 2J_\times. Following this insight we then suggest that changing these competing inter-chain exchanges from the previously considered antiferromagnetic to the ferromagnetic ones eliminates the issue of the marginal interactions altogether and dramatically expands the region of stability of the columnar dimer phase. This analytical prediction is convincingly confirmed by the numerical density matrix renormalization group and exact diagonalization calculations as well as by the perturbative calculation in the strong rung-coupling limit. The phase diagram for ferromagnetic J_\perp and J_\times is determined.Comment: 12 pages, 12 figures, 1 Table. v2: version to appear in Phys. Rev.

Constraining short-range spin-dependent forces with polarized helium 3 at the Laue-Langevin Institute

We have searched for a short-range spin-dependent interaction mediated by a hypothetical light scalar boson with CP-violating couplings to the neutron using the spin relaxation of hyperpolarized $^3$He. The walls of the $^3$He cell would generate a depolarizing pseudomagnetic field.Comment: Twelfth Conference on the Intersections of Particle and Nuclear Physics (CIPANP2015), Vail Marriott Mountain Resort, Vail, Colorado, US

Small Angle Scattering by Fractal Aggregates: A Numerical Investigation of the Crossover Between the Fractal Regime and the Porod Regime

Fractal aggregates are built on a computer using off-lattice cluster-cluster aggregation models. The aggregates are made of spherical particles of different sizes distributed according to a Gaussian-like distribution characterised by a mean $a_0$ and a standard deviation $\sigma$. The wave vector dependent scattered intensity $I(q)$ is computed in order to study the influence of the particle polydispersity on the crossover between the fractal regime and the Porod regime. It is shown that, given $a_0$, the location $q_c$ of the crossover decreases as $\sigma$ increases. The dependence of $q_c$ on $\sigma$ can be understood from the evolution of the shape of the center-to-center interparticle-distance distribution function.Comment: RevTex, 4 pages + 6 postscript figures, compressed using "uufiles", published in Phys. Rev. B 50, 1305 (1994

Influence of surfactants on the structure of titanium oxide gels : experiments and simulations

We report here on experimental and numerical studies of the influence of surfactants on mineral gel synthesis. The modification of the gel structure when the ratios water-precursor and water-surfactant vary is brought to the fore by fractal dimension measures. A property of {\em polydispersity of the initial hydrolysis} is proposed to explain these results, and is successfuly tested through numerical experiments of three dimensional chemically limited aggregation.Comment: 12 pages, 4 Postscript figures, uses RevTe

Pharmaceutical innovation, reference pricing and therapeutic classes

This paper is a first attempt to model the effects of reference pricing on the innovation effort of pharmaceutical firms. The model is based on a dynamic game involving three types of agents: pharmaceutical firms, consumers and a regulatory entity. The games includes research stages where the innovation efforts by the firms are determined and introductory stages where a price for a new medicament is fixed. We model the negotiation between the drug owner and the regulator to fix the price, first without legal constraint, second under the regime of reference pricing in therapeutic classes. We then solve the innovation game where the firms anticipate the results of the negotiation round on prices. We thus consider the effect of the therapeutic class regulation on both prices and the innovation pace. The final stage consists in calibrating the model with a small data on anti-statine in France and simulates the effect of the change in regulatory regime

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action

Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to provide disease control. Numerous biological therapies are in various stages of clinical development, with expectation of providing enhanced safety and efficacy over currently available psoriasis therapies. Efalizumab, a recombinant humanized monoclonal IgG1 antibody, is a novel targeted T-cell modulator that inhibits multiple steps in the immune cascade that result in the production and maintenance of psoriatic plaques, including initial T-cell activation and T-cell trafficking into sites of inflammation, including psoriatic skin, with subsequent reactivation in these sites. This article reviews the pharmacodynamic, pharmacokinetic and clinical effects observed during phase I, II and III efalizumab trials in patients with moderate to severe chronic plaque psoriasis. Copyright (C) 2004 S. Karger AG, Basel

Fluctuating Bond Aggregation: a Model for Chemical Gel Formation

The Diffusion-Limited Cluster-Cluster Aggregation (DLCA) model is modified by including cluster deformations using the {\it bond fluctuation} algorithm. From 3$d$ computer simulations, it is shown that, below a given threshold value $c_g$ of the volumic fraction $c$, the realization of all intra-aggregate bonding possibilities prevents the formation of a gelling network. For $c>c_g$, the sol-gel transition occurs at a time $t_g$ which, in contrast to DLCA, doesnot diverge with the box size. Several results are reported including small angle scattering curves and possible applications are discussed.Comment: RevTex, 9 pages + 3 postscript figures appended using "uufiles". To appear in Phys. Rev. Let