A.: Substance P N-terminal metabolites and nitric oxide mediate capsaicin-induced antinociception in the adult

ABSTRACT ABBREViATIONS L-NAME, N '-nitro-L-arginine methyl ester; l.t., intrathecal; D-NAME, N "-nitro-D-arginine methyl ester. These findings suggest NO is produced and acts within capsaicin-sensitive primary afferent fibers in the dorsal spinal cord to mobilize substance P, resulting in N-terminal induced-antinociception