Typical short-axis cine-MRI frames obtained in vivo at 9.4T with the surface coil that allowed the assessment of the left the ventricle wall thickness.

<p>Typically, the frames obtained at the end of the ventricle relaxation (diastole) show the presence of concentric hypertrophy in hypertensive (SHR) rats (see the arrow) at age 21-wk while the phenomenon was absent at 12-wk in SHR as well at any age in control (WKY) rats.</p

Main characteristics in WKY and SHR at the beginning and at the end of the follow-up.

<p>Main characteristics in WKY and SHR at the beginning and at the end of the follow-up.</p

Results obtained on tubes containing PCr and ATP to calibrate the OVs spectroscopy method.

<p>a: a typical spectrum with signal/noise (S/N) ratio of 20 obtained with the OVS method in 1 min 36 s, with the saturation bands positioned outside of the tubes. b: spectra obtained for different positions of the saturation slice. c: PCr and ATPγ signal intensities as a function of the position of the saturation slice covering the tube containing the PCr. The reference in position is between the two tubes. The horizontal bar at the bottom of the graphs shows the noise level (σ_n). d: Typical positioning of saturation slices (around the virtual square) in cardiac localized spectroscopy in vivo that takes into account the 3 mm overlap required to ensure the attenuation of ³¹PCr signal from (non cardiac) chest skeletal muscles.</p

Weekly ratios of PCr/ATPγ in control (WKY, square symbols) and hypertensive (SHR, circles) rats.

<p>Horizontal lines indicate average values, 0.99 and 0.95 confidence intervals to highlight narrow intra- and owner-individual variations, great consistency in repeated ³¹P-MR assessments, and energy homeostasis along weeks.</p

Comparison between infarcted and mirrored normoxic areas in patients.

<p>Histogram and scatter-plot of pooled 9 infarcted areas (‘stroke’) versus unaffected mirror areas (‘control’). <b>3.a</b>: Histograms demonstrated that the shift to lower values of lipids R₁ in stroke areas (0.408 s^-1; p<0.0001) is more pronounced than the corresponding shift observed with global R₁ values (0.154 s^-1; p<0.027). <b>3.b</b>: Scatter plots demonstrated a greater difference between medians for lipids R₁ at 0.409 s^-1 with p <0.0001 (in orange) than for global R₁ at 0.151 s^-1 with p<0.027 (in blue).</p

Statistical details: statistical tests were performed depending on results of the D’Agostino & Pearson test for the normality of the data distribution with a parametric test (classic) used in cases of normal distribution, and non-parametric tests (bold and italic) used in cases of non-normal distribution.

<p>Calculations were performed using paired tests when both datasets were obtained from the same patient. The p values are given for each patient (P#X).</p

Full display of morphological/quantitative data sets obtained in a patient.

<p>Axial transverse FLAIR image (<b>1.a</b>) through centrum semiovale showing hyperintensity within acutely infarcted whole territory of the right middle cerebral artery (MCA), and corresponding global R₁-mapped image (<b>1.b</b>), lipids R₁-mapped image (MOBILE) (<b>1.c</b>) and R₂*-mapped image (<b>1.d</b>) in a similar slice location. Image 1.e: overlay of the two ROIs (right-sided contour of infarction and left-sided mirrored one) from the MOBILE map (<b>1.b</b>) on the FLAIR image (<b>1.a</b>). Images 1b-1e have been smoothed using the ‘Gaussian Blur’ function (radius of 2 pixels) of the GIMP software (GIMP 2, GNU Image Manipulation Program, GPLv3). Histograms of global R₁ (<b>1.f</b>), lipids R₁ (<b>1.g</b>) and R₂* (<b>1.h</b>) of the same patient demonstrating significant shift of the medians to lower values for the stroke area. Differences of 0.111 s^-1, 0.536 s^-1 and 6.09 s^-1 are observed for global R₁, lipids R₁ and R₂*, respectively.</p

Healthy volunteers’ brain tissue (‘Volunteers’) versus unaffected mirror-areas in stroke patients (‘Control’) versus infarcts (‘Stroke’).

<p>Global R₁ plots (3.a), Lipids R₁ plots (3.b) and R₂* plots (3.c) demonstrated a statistically significant difference between infarcts and unaffected mirror-ROIs in patients. In turn, no difference was observed for all modalities between the values obtained in patient mirror-ROIs and healthy brain tissue in volunteers.</p