The effect of increased channel interaction on speech perception with cochlear implants.

Cochlear implants (CIs) are neuroprostheses that partially restore hearing for people with severe-to-profound hearing loss. While CIs can provide good speech perception in quiet listening situations for many, they fail to do so in environments with interfering sounds for most listeners. Previous research suggests that this is due to detrimental interaction effects between CI electrode channels, limiting their function to convey frequency-specific information, but evidence is still scarce. In this study, an experimental manipulation called spectral blurring was used to increase channel interaction in CI listeners using Advanced Bionics devices with HiFocus 1J and MS electrode arrays to directly investigate its causal effect on speech perception. Instead of using a single electrode per channel as in standard CI processing, spectral blurring used up to 6 electrodes per channel simultaneously to increase the overlap between adjacent frequency channels as would occur in cases with severe channel interaction. Results demonstrated that this manipulation significantly degraded CI speech perception in quiet by 15% and speech reception thresholds in babble noise by 5 dB when all channels were blurred by a factor of 6. Importantly, when channel interaction was increased just on a subset of electrodes, speech scores were mostly unaffected and were only significantly degraded when the 5 most apical channels were blurred. These apical channels convey information up to 1 kHz at the apical end of the electrode array and are typically located at angular insertion depths of about 250 up to 500°. These results confirm and extend earlier findings indicating that CI speech perception may not benefit from deactivating individual channels along the array and that efforts should instead be directed towards reducing channel interaction per se and in particular for the most-apical electrodes. Hereby, causal methods such as spectral blurring could be used in future research to control channel interaction effects within listeners for evaluating compensation strategies

The effect of increased channel interaction on speech perception with cochlear implants.

Cochlear implants (CIs) are neuroprostheses that partially restore hearing for people with severe-to-profound hearing loss. While CIs can provide good speech perception in quiet listening situations for many, they fail to do so in environments with interfering sounds for most listeners. Previous research suggests that this is due to detrimental interaction effects between CI electrode channels, limiting their function to convey frequency-specific information, but evidence is still scarce. In this study, an experimental manipulation called spectral blurring was used to increase channel interaction in CI listeners using Advanced Bionics devices with HiFocus 1J and MS electrode arrays to directly investigate its causal effect on speech perception. Instead of using a single electrode per channel as in standard CI processing, spectral blurring used up to 6 electrodes per channel simultaneously to increase the overlap between adjacent frequency channels as would occur in cases with severe channel interaction. Results demonstrated that this manipulation significantly degraded CI speech perception in quiet by 15% and speech reception thresholds in babble noise by 5 dB when all channels were blurred by a factor of 6. Importantly, when channel interaction was increased just on a subset of electrodes, speech scores were mostly unaffected and were only significantly degraded when the 5 most apical channels were blurred. These apical channels convey information up to 1 kHz at the apical end of the electrode array and are typically located at angular insertion depths of about 250 up to 500°. These results confirm and extend earlier findings indicating that CI speech perception may not benefit from deactivating individual channels along the array and that efforts should instead be directed towards reducing channel interaction per se and in particular for the most-apical electrodes. Hereby, causal methods such as spectral blurring could be used in future research to control channel interaction effects within listeners for evaluating compensation strategies

Using Spectral Blurring to Assess Effects of Channel Interaction on Speech-in-Noise Perception with Cochlear Implants

Abstract: Cochlear implant (CI) listeners struggle to understand speech in background noise. Interactions between electrode channels due to current spread increase the masking of speech by noise and lead to difficulties with speech perception. Strategies that reduce channel interaction therefore have the potential to improve speech-in-noise perception by CI listeners, but previous results have been mixed. We investigated the effects of channel interaction on speech-in-noise perception and its association with spectro-temporal acuity in a listening study with 12 experienced CI users. Instead of attempting to reduce channel interaction, we introduced spectral blurring to simulate some of the effects of channel interaction by adjusting the overlap between electrode channels at the input level of the analysis filters or at the output by using several simultaneously stimulated electrodes per channel. We measured speech reception thresholds in noise as a function of the amount of blurring applied to either all 15 electrode channels or to 5 evenly spaced channels. Performance remained roughly constant as the amount of blurring applied to all channels increased up to some knee point, above which it deteriorated. This knee point differed across listeners in a way that correlated with performance on a non-speech spectro-temporal task, and is proposed here as an individual measure of channel interaction. Surprisingly, even extreme amounts of blurring applied to 5 channels did not affect performance. The effects on speech perception in noise were similar for blurring at the input and at the output of the CI. The results are in line with the assumption that experienced CI users can make use of a limited number of effective channels of information and tolerate some deviations from their everyday settings when identifying speech in the presence of a masker. Furthermore, these findings may explain the mixed results by strategies that optimized or deactivated a small number of electrodes evenly distributed along the array by showing that blurring or deactivating one-third of the electrodes did not harm speech-in-noise performance

Auditory Cortical Images of Tones and Noise Bands

We examined the representation of stimulus center frequencies by the distribution of cortical activity. Recordings were made from the primary auditory cortex (area A1) of ketamine-anesthetized guinea pigs. Cortical images of tones and noise bands were visualized as the simultaneously recorded spike activity of neurons at 16 sites along the tonotopic gradient of cortical frequency representation. The cortical image of a pure tone showed a restricted focus of activity along the tonotopic gradient. As the stimulus frequency was increased, the location of the activation focus shifted from rostral to caudal. When cochlear activation was broadened by increasing the stimulus level or bandwidth, the cortical image broadened. An artificial neural network algorithm was used to quantify the accuracy of center-frequency representation by small populations of cortical neurons. The artificial neural network identified stimulus center frequency based on single-trial spike counts at as few as ten sites. The performance of the artificial neural network under various conditions of stimulus level and bandwidth suggests that the accuracy of representation of center frequency is largely insensitive to changes in the width of cortical images.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41376/1/10162_2000_Article_36.pd

Using Spectral Blurring to Assess Effects of Channel Interaction on Speech-in-Noise Perception with Cochlear Implants

Abstract: Cochlear implant (CI) listeners struggle to understand speech in background noise. Interactions between electrode channels due to current spread increase the masking of speech by noise and lead to difficulties with speech perception. Strategies that reduce channel interaction therefore have the potential to improve speech-in-noise perception by CI listeners, but previous results have been mixed. We investigated the effects of channel interaction on speech-in-noise perception and its association with spectro-temporal acuity in a listening study with 12 experienced CI users. Instead of attempting to reduce channel interaction, we introduced spectral blurring to simulate some of the effects of channel interaction by adjusting the overlap between electrode channels at the input level of the analysis filters or at the output by using several simultaneously stimulated electrodes per channel. We measured speech reception thresholds in noise as a function of the amount of blurring applied to either all 15 electrode channels or to 5 evenly spaced channels. Performance remained roughly constant as the amount of blurring applied to all channels increased up to some knee point, above which it deteriorated. This knee point differed across listeners in a way that correlated with performance on a non-speech spectro-temporal task, and is proposed here as an individual measure of channel interaction. Surprisingly, even extreme amounts of blurring applied to 5 channels did not affect performance. The effects on speech perception in noise were similar for blurring at the input and at the output of the CI. The results are in line with the assumption that experienced CI users can make use of a limited number of effective channels of information and tolerate some deviations from their everyday settings when identifying speech in the presence of a masker. Furthermore, these findings may explain the mixed results by strategies that optimized or deactivated a small number of electrodes evenly distributed along the array by showing that blurring or deactivating one-third of the electrodes did not harm speech-in-noise performance

A Site-Selection Strategy Based on Polarity Sensitivity for Cochlear Implants: Effects on Spectro-Temporal Resolution and Speech Perception

ABSTRACT: Thresholds of asymmetric pulses presented to cochlear implant (CI) listeners depend on polarity in a way that differs across subjects and electrodes. It has been suggested that lower thresholds for cathodic-dominant compared to anodic-dominant pulses reflect good local neural health. We evaluated the hypothesis that this polarity effect (PE) can be used in a site-selection strategy to improve speech perception and spectro-temporal resolution. Detection thresholds were measured in eight users of Advanced Bionics CIs for 80-pps, triphasic, monopolar pulse trains where the central high-amplitude phase was either anodic or cathodic. Two experimental MAPs were then generated for each subject by deactivating the five electrodes with either the highest or the lowest PE magnitudes (cathodic minus anodic threshold). Performance with the two experimental MAPs was evaluated using two spectro-temporal tests (Spectro-Temporal Ripple for Investigating Processor EffectivenesS (STRIPES; Archer-Boyd et al. in J Acoust Soc Am 144:2983–2997, 2018) and Spectral-Temporally Modulated Ripple Test (SMRT; Aronoff and Landsberger in J Acoust Soc Am 134:EL217–EL222, 2013)) and with speech recognition in quiet and in noise. Performance was also measured with an experimental MAP that used all electrodes, similar to the subjects’ clinical MAP. The PE varied strongly across subjects and electrodes, with substantial magnitudes relative to the electrical dynamic range. There were no significant differences in performance between the three MAPs at group level, but there were significant effects at subject level—not all of which were in the hypothesized direction—consistent with previous reports of a large variability in CI users’ performance and in the potential benefit of site-selection strategies. The STRIPES but not the SMRT test successfully predicted which strategy produced the best speech-in-noise performance on a subject-by-subject basis. The average PE across electrodes correlated significantly with subject age, duration of deafness, and speech perception scores, consistent with a relationship between PE and neural health. These findings motivate further investigations into site-specific measures of neural health and their application to CI processing strategies

Assessing Cognitive Abilities in High-Performing Cochlear Implant Users

Despite being considered one of the most successful neural prostheses, cochlear implants (CIs) provide recipients with a wide range of speech perception performance. While some CI users can understand speech in the absence of visual cues, other recipients exhibit more limited speech perception. Cognitive skills have been documented as a contributor to complex auditory processing, such as language understanding; however, there are no normative data for existing standardized clinical tests assessing cognitive abilities in CI users. Here, we assess the impact of modality of presentation (i.e., auditory-visual versus visual) for the administration of working memory tests in high-performing CI users in addition to measuring processing speed, cognitive efficiency and intelligence quotient (IQ). Second, we relate performance on these cognitive measures to clinical CI speech perception outcomes.Methods: Twenty one post-lingually deafened, high-performing, adult CI users [age range: 52–88 years; 3 unilateral CI, 13 bimodal (i.e., CI with contralateral hearing aid), 5 bilateral CI] with clinical speech perception scores (i.e., AzBio sentences in quiet for the first-ear CI) of ≥60% were recruited. A cognitive test battery assessing auditory-visual working memory (AVWM), visual working memory (VWM), processing speed, cognitive efficiency and IQ was administered, in addition to clinical measures of speech perception in quiet (i.e., AzBio sentences in quiet). AzBio sentences were assessed in two conditions: first-ear CI only, and best-aided everyday wearing condition. Subjects also provided self-reported measures of performance and benefit from their CI using standardized materials, including the Glasgow Benefit Inventory (GBI) and the Nijmegen Cochlear Implant questionnaire (NCIQ).Results: High-performing CI users demonstrated greater VWM than AVWM recall. VWM was positively related to AzBio scores when measured in the first-ear CI only. AVWM, processing speed, cognitive efficiency, and IQ did not relate to either measure of speech perception (i.e., first-ear CI or best-aided conditions). Subjects’ self-reported benefit as measured by the GBI predicted best-aided CI speech perception performance.Conclusion: In high-performing CI recipients, visual presentation of working memory tests may improve our assessment of cognitive function

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure