Dietary Supplement Use in Young Elite Athletes and School Children Aged 11 to 13 Years: A Cross-Sectional Study Design

Objective: Information about dietary supplement (DS) use in young German athletes beginning their sporting career is scarce and possible differences to their non-athlete counterparts are unknown. Therefore, the purpose of this study was to analyze DS use in young elite German athletes (A) and non-athlete (NA) controls. Method: During pre-participation examinations, 562 athletes (323m/239f, 11.7±0.6 years) and 69 non-athletes (12m/57f; 12.5±0.5 years) answered a standardized questionnaire analyzing the prevalence of DS use, reasons for intake, and sources of information. Group differences were analyzed with Chi² test (α=0.05). Results: 14% of A and 20% of NA used DS, with no statistically significant differences between groups (p=0.231). Magnesium (A: 35%; NA: 36%) and calcium (A: 28%; NA: 7%) were the most frequently used minerals. Vitamin C (A: 37%; NA: 36%) and multi-vitamin supplements (A: 40%; NA: 29%) were the most often used vitamins. The main reason for DS intake was for health improvement (A: 77%; NA: 71%). The main information source was cited as their parents (A: 66%, NA: 71%). Discussion: Young German athletes beginning their sporting career show similar supplementation habits astheir non-athletic counterparts. Compared to the literature, prevalence of DS use amongst the observed athletes is low. This is likely to increase with age and growing performance level. Keeping that and possible doping infractions or overdoses in mind, nutritional education should start early in ones sporting career and should include the parents

No Till and Organic Farming Improve Soil Properties but Reduce Crop Yield Compared to Conventional Farming in a Swiss Farm Network

Soils are of vital importance for sustainable food production. In order to maintain or improve soil quality, it is necessary to develop strategies for a sustainable use of soil. Alternative cropping practices such as reduced tillage and improved crop rotation are more and more adopted with the aim of decreasing the impact of agriculture on the environment. However, their on-the-ground impact in Swiss farming systems still has to be assessed. In this study, we quantified the impact of three farming systems (conventional farming, no-till, and organic farming) on plant and soil chemical, biological and physical properties. Our study included 20 fields for each farming system. All selected fields were cultivated with winter wheat the year of sampling. Soil was sampled at four layers, 0-5 cm, 5-20 cm, 20-25 cm, 25-50 cm. The main variables analysed were grain yield, soil nutrient availability, organic carbon stocks, bulk density, aggregation, porosity and soil biology. This was complemented with a comprehensive survey to collect information about cropping practices at field and farm scale, including organic matter inputs, fertilisation, tillage, phytosanitary treatments, and crop rotation.Our results show a significant influence of cropping practices on plant and soil properties. Wheat yield in no till and organic systems was reduced by 10% and 30% compared to conventional systems. Bulk density was higher in no-till than in ploughed fields in the 5-20 cm layer but similar in the subsoil. A strong stratification with depth of nutrients and soil organic carbon was observed in no-till fields. No-till and organic fields showed larger soil aggregates and higher microbial biomass in the surface layer (0-5 cm). Mycorrhizal colonisation of wheat roots was on average 50% higher in organic fields. However, no differences in carbon stock in the 0-20 cm layer was observed and the ratio organic matter / clay shows a high variability (from poor to good) and was not dependent on the farming system.Our results show that an improvement of soil properties can be achieved with alternative cropping practices such as no-till and organic farming, but also depends on the other practices adopted by the farmers, such as input of organic amendments, crop rotation diversification, residue management

Wurzelbürtige Stickstoff- und Kohlenstoffeinträge in den Boden: Erkenntnisse aus sieben Jahren DOK Wurzelforschung

We investigated nitrogen and carbon below ground inputs of soybean, clover-grass and maize and management effects of biological and conventional systems in the DOK long term experiment. We found for soybean increasing below ground C and N inputs with decreasing fertilization intensity whereas those effects were small for clover-grass. Below ground nitrogen inputs of red clover could be estimated by above ground N multiplied with a factor of 0.5

Enfrentamento à violência de gênero contra a mulher: estudo comparado das leis e políticas públicas do Brasil e da França: Confronting gender-based violence against women: a comparative study of laws and public policies of Brazil and France

Este trabalho objetiva analisar as legislações e políticas públicas do Brasil e da França no tocante ao enfrentamento à violência de gênero contra a mulher, utilizando a metodologia qualitativa de análise documental, em especial, a Lei n. 11.340/2006 (Lei Maria da Penha) e a Lei n. 13.104/2015 (Feminicídio). E, para fins de estudo comparado, a coletânea “Les droits des femmes face aux violences” elaborada por Marlène Schiappa. Efetuou-se uma abordagem sobre o sistema Civil Law e outros pontos de convergência entre o Brasil e a França. Foram analisadas as legislações mostrando as políticas públicas desses Países nesse enfrentamento. Referida pesquisa se mostra relevante para promover a compreensão de como são tratados os temas sobre violência de gênero contra as mulheres

Influence of Obesity on Foot Loading Characteristics in Gait for Children Aged 1 to 12 Years

Background Overweight and obesity are increasing health problems that are not restricted to adults only. Childhood obesity is associated with metabolic, psychological and musculoskeletal comorbidities. However, knowledge about the effect of obesity on the foot function across maturation is lacking. Decreased foot function with disproportional loading characteristics is expected for obese children. The aim of this study was to examine foot loading characteristics during gait of normal-weight, overweight and obese children aged 1–12 years. Methods A total of 10382 children aged one to twelve years were enrolled in the study. Finally, 7575 children (m/f: n = 3630/3945; 7.0±2.9yr; 1.23±0.19m; 26.6±10.6kg; BMI: 17.1±2.4kg/m2) were included for (complete case) data analysis. Children were categorized to normal-weight (≥3rd and 97th percentile; n = 371) according to the German reference system that is based on age and gender-specific body mass indices (BMI). Plantar pressure measurements were assessed during gait on an instrumented walkway. Contact area, arch index (AI), peak pressure (PP) and force time integral (FTI) were calculated for the total, fore-, mid- and hindfoot. Data was analyzed descriptively (mean ± SD) followed by ANOVA/Welch-test (according to homogeneity of variances: yes/no) for group differences according to BMI categorization (normal-weight, overweight, obesity) and for each age group 1 to 12yrs (post-hoc Tukey Kramer/Dunnett’s C; α = 0.05). Results Mean walking velocity was 0.95 ± 0.25 m/s with no differences between normal-weight, overweight or obese children (p = 0.0841). Results show higher foot contact area, arch index, peak pressure and force time integral in overweight and obese children (p<0.001). Obese children showed the 1.48-fold (1 year-old) to 3.49-fold (10 year-old) midfoot loading (FTI) compared to normal-weight. Conclusion Additional body mass leads to higher overall load, with disproportional impact on the midfoot area and longitudinal foot arch showing characteristic foot loading patterns. Already the feet of one and two year old children are significantly affected. Childhood overweight and obesity is not compensated by the musculoskeletal system. To avoid excessive foot loading with potential risk of discomfort or pain in childhood, prevention strategies should be developed and validated for children with a high body mass index and functional changes in the midfoot area. The presented plantar pressure values could additionally serve as reference data to identify suspicious foot loading patterns in children

Reflexões sobre bolsonarismo e violência policial: assassinatos e violações de Direitos Humanos de travestis e transgêneros no Brasil

O presente artigo busca fazer uma reflexão do bolsonarismo e da violência policial com o enfoque no assassinato e na violação de direitos humanos dos travestis e transgêneros no Brasil. Nosso problema de pesquisa consiste em analisar a influência do bolsonarismo na violência policial em se tratando de assassinato de pessoas trans e travestis. A metodologia utilizada é a bibliográfica e a análise documental do dossiê ANTRA sobre assassinato de transgêneros e travestis

The dynamical association between physical activity and affect in the daily life of individuals with ADHD

ADHD, Mood; Physical activityTDAH; Estado anímico; Actividad físicaTDAH; Estat anímic; Activitat físicaExercise interventions in mental disorders have evidenced a mood-enhancing effect. However, the association between physical activity and affect in everyday life has not been investigated in adult individuals with ADHD, despite being important features of this disorder. As physical activity and affect are dynamic processes in nature, assessing those in everyday life with e-diaries and wearables, has become the gold standard. Thus, we used an mHealth approach to prospectively assess physical activity and affect processes in individuals with ADHD and controls aged 14–45 years. Participants wore accelerometers across a four-day period and reported their affect via e-diaries twelve times daily. We used multilevel models to identify the within-subject effects of physical activity on positive and negative affect. We split our sample into three groups: 1. individuals with ADHD who were predominantly inattentive (n = 48), 2. individuals with ADHD having a combined presentation (i.e., being inattentive and hyperactive; n = 95), and 3. controls (n = 42). Our analyses revealed a significant cross-level interaction (F(2, 135.072)=5.733, p = 0.004) of physical activity and group on positive affect. In details, all groups showed a positive association between physical activity and positive affect. Individuals with a combined presentation significantly showed the steepest slope of physical activity on positive affect (slope_inattentive=0.005, p<0.001; slope_combined=0.009, p<0.001; slope_controls=0.004, p = 0.008). Our analyses on negative affect revealed a negative association only in the individuals with a combined presentation (slope=-0.003; p = 0.001). Whether this specifically pronounced association in individuals being more hyperactive might be a mechanism reinforcing hyperactivity needs to be empirically clarified in future studies

Effects of sudden walking perturbations on neuromuscular reflex activity and three-dimensional motion of the trunk in healthy controls and back pain symptomatic subjects.

Background Back pain patients (BPP) show delayed muscle onset, increased co-contractions, and variability as response to quasi-static sudden trunk loading in comparison to healthy controls (H). However, it is unclear whether these results can validly be transferred to suddenly applied walking perturbations, an automated but more functional and complex movement pattern. There is an evident need to develop research-based strategies for the rehabilitation of back pain. Therefore, the investigation of differences in trunk stability between H and BPP in functional movements is of primary interest in order to define suitable intervention regimes. The purpose of this study was to analyse neuromuscular reflex activity as well as three-dimensional trunk kinematics between H and BPP during walking perturbations. Methods Eighty H (31m/49f;29±9yrs;174±10cm;71±13kg) and 14 BPP (6m/8f;30±8yrs;171±10cm;67±14kg) walked (1m/s) on a split-belt treadmill while 15 right-sided perturbations (belt decelerating, 40m/s2, 50ms duration; 200ms after heel contact) were randomly applied. Trunk muscle activity was assessed using a 12-lead EMG set-up. Trunk kinematics were measured using a 3-segment-model consisting of 12 markers (upper thoracic (UTA), lower thoracic (LTA), lumbar area (LA)). EMG-RMS ([%],0-200ms after perturbation) was calculated and normalized to the RMS of unperturbed gait. Latency (TON;ms) and time to maximum activity (TMAX;ms) were analysed. Total motion amplitude (ROM;[°]) and mean angle (Amean;[°]) for extension-flexion, lateral flexion and rotation were calculated (whole stride cycle; 0-200ms after perturbation) for each of the three segments during unperturbed and perturbed gait. For ROM only, perturbed was normalized to unperturbed step [%] for the whole stride as well as the 200ms after perturbation. Data were analysed descriptively followed by a student´s t-test to account for group differences. Co-contraction was analyzed between ventral and dorsal muscles (V:R) as well as side right:side left ratio (Sright:Sleft). The coefficient of variation (CV;%) was calculated (EMG-RMS;ROM) to evaluate variability between the 15 perturbations for all groups. With respect to unequal distribution of participants to groups, an additional matched-group analysis was conducted. Fourteen healthy controls out of group H were sex-, age- and anthropometrically matched (group Hmatched) to the BPP. Results No group differences were observed for EMG-RMS or CV analysis (EMG/ROM) (p>0.025). Co-contraction analysis revealed no differences for V:R and Srigth:Sleft between the groups (p>0.025). BPP showed an increased TON and TMAX, being significant for Mm. rectus abdominus (p = 0.019) and erector spinae T9/L3 (p = 0.005/p = 0.015). ROM analysis over the unperturbed stride cycle revealed no differences between groups (p>0.025). Normalization of perturbed to unperturbed step lead to significant differences for the lumbar segment (LA) in lateral flexion with BPP showing higher normalized ROM compared to Hmatched (p = 0.02). BPP showed a significant higher flexed posture (UTA (p = 0.02); LTA (p = 0.004)) during normal walking (Amean). Trunk posture (Amean) during perturbation showed higher trunk extension values in LTA segments for H/Hmatched compared to BPP (p = 0.003). Matched group (BPP vs. Hmatched) analysis did not show any systematic changes of all results between groups. Conclusion BPP present impaired muscle response times and trunk posture, especially in the sagittal and transversal planes, compared to H. This could indicate reduced trunk stability and higher loading during gait perturbations

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germinal zone of the embryonic basal ganglia. How genetic information in the germinal zone determines cell types is unclear. Here we use a combination of in vivo CRISPR perturbation, lineage tracing and ChIP-sequencing analyses and show that the transcription factor MEIS2 favors the development of projection neurons by binding enhancer regions in projection-neuron-specific genes during mouse embryonic development. MEIS2 requires the presence of the homeodomain transcription factor DLX5 to direct its functional activity toward the appropriate binding sites. In interneuron precursors, the transcription factor LHX6 represses the MEIS2-DLX5-dependent activation of projection-neuron-specific enhancers. Mutations of Meis2 result in decreased activation of regulatory enhancers, affecting GABAergic differentiation. We propose a differential binding model where the binding of transcription factors at cis-regulatory elements determines differential gene expression programs regulating cell fate specification in the mouse ganglionic eminence. How genetic information in the germinal zone determines neuronal cell types is unclear. Here the authors show that MEIS2 plays an important role in determining GABAergic neuron diversity during development