Hubble Space Telescope Combined Strong and Weak Lensing Analysis of the CLASH Sample: Mass and Magnification Models and Systematic Uncertainties

We present results from a comprehensive lensing analysis in HST data, of the complete CLASH cluster sample. We identify new multiple-images previously undiscovered allowing improved or first constraints on the cluster inner mass distributions and profiles. We combine these strong-lensing constraints with weak-lensing shape measurements within the HST FOV to jointly constrain the mass distributions. The analysis is performed in two different common parameterizations (one adopts light-traces-mass for both galaxies and dark matter while the other adopts an analytical, elliptical NFW form for the dark matter), to provide a better assessment of the underlying systematics - which is most important for deep, cluster-lensing surveys, especially when studying magnified high-redshift objects. We find that the typical (median), relative systematic differences throughout the central FOV are $\sim40\%$ in the (dimensionless) mass density, $\kappa$, and $\sim20\%$ in the magnification, $\mu$. We show maps of these differences for each cluster, as well as the mass distributions, critical curves, and 2D integrated mass profiles. For the Einstein radii ($z_{s}=2$) we find that all typically agree within $10\%$ between the two models, and Einstein masses agree, typically, within $\sim15\%$. At larger radii, the total projected, 2D integrated mass profiles of the two models, within r\sim2\arcmin, differ by $\sim30\%$. Stacking the surface-density profiles of the sample from the two methods together, we obtain an average slope of $d\log (\Sigma)/d\log(r)\sim-0.64\pm0.1$, in the radial range [5,350] kpc. Lastly, we also characterize the behavior of the average magnification, surface density, and shear differences between the two models, as a function of both the radius from the center, and the best-fit values of these quantities.Comment: 35 pages (20 main text pages, plus 15 pages for additional figures and tables); 2 Tables, 17 Figures. V3: accepted version; some minor corrections and additions made. V4: corrected several entries in Table 2. All mass models and magnification maps are made publicly available for the communit

CLASH: Mass Distribution in and around MACS J1206.2-0847 from a Full Cluster Lensing Analysis

We derive an accurate mass distribution of the galaxy cluster MACS J1206.2-0847 (z=0.439) from a combined weak-lensing distortion, magnification, and strong-lensing analysis of wide-field Subaru BVRIz' imaging and our recent 16-band Hubble Space Telescope observations taken as part of the Cluster Lensing And Supernova survey with Hubble (CLASH) program. We find good agreement in the regions of overlap between several weak and strong lensing mass reconstructions using a wide variety of modeling methods, ensuring consistency. The Subaru data reveal the presence of a surrounding large scale structure with the major axis running approximately north-west south-east (NW-SE), aligned with the cluster and its brightest galaxy shapes, showing elongation with a \sim 2:1 axis ratio in the plane of the sky. Our full-lensing mass profile exhibits a shallow profile slope dln\Sigma/dlnR\sim -1 at cluster outskirts (R>1Mpc/h), whereas the mass distribution excluding the NW-SE excess regions steepens further out, well described by the Navarro-Frenk-White form. Assuming a spherical halo, we obtain a virial mass M_{vir}=(1.1\pm 0.2\pm 0.1)\times 10^{15} M_{sun}/h and a halo concentration c_{vir} = 6.9\pm 1.0\pm 1.2 (\sim 5.7 when the central 50kpc/h is excluded), which falls in the range 4 <7 of average c(M,z) predictions for relaxed clusters from recent Lambda cold dark matter simulations. Our full lensing results are found to be in agreement with X-ray mass measurements where the data overlap, and when combined with Chandra gas mass measurements, yield a cumulative gas mass fraction of 13.7^{+4.5}_{-3.0}% at 0.7Mpc/h (\approx 1.7r_{2500}), a typical value observed for high mass clusters.Comment: Accepted by ApJ (30 pages, 17 figures), one new figure (Figure 10) added, minor text changes; a version with high resolution figures available at http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/MACS1206/ms_highreso.pd

Local partitioning of the overturning circulation in the tropics and the connection to the Hadley and Walker circulations

Conceptually, it is useful to partition the three-dimensional tropical circulation into meridional and zonal components, namely, the Hadley and Walker circulations. The averaging involved in their definitions can introduce ambiguities. These problems can be circumvented by first partitioning the total vertical mass flux into components associated with overturning in the meridional and zonal directions, respectively, called here the local Hadley and local Walker circulations. Defining the local Hadley and local Walker circulations this way ensures the pair of two-dimensional overturning circulations can be added to give the original three-dimensional circulation, even when the averages are taken over limited domains. The method is applied to the vertical motion from the ERA-Interim reanalysis for the period 1979 to 2009. One important result is that the local Hadley circulation responds much more strongly to ENSO than the local Walker circulation, even though the local Walker circulation in the central Pacific weakens during El Niño years and strengthens and widens during La Niña years

Edge-resolved transient imaging: performance analyses, optimizations, and simulations

Edge-resolved transient imaging (ERTI) is a method for non-line-of-sight imaging that combines the use of direct time of flight for measuring distances with the azimuthal angular resolution afforded by a vertical edge occluder. Recently conceived and demonstrated for the first time, no performance analyses or optimizations of ERTI have appeared in published papers. This paper explains how the difficulty of detection of hidden scene objects with ERTI depends on a variety of parameters, including illumination power, acquisition time, ambient light, visible-side reflectivity, hidden-side reflectivity, target range, and target azimuthal angular position. Based on this analysis, optimization of the acquisition process is introduced whereby the illumination dwell times are varied to counteract decreasing signal-to-noise ratio at deeper angles into the hidden volume. Inaccuracy caused by a coaxial approximation is also analyzed and simulated.Accepted manuscrip

Dendritic/antigen presenting cell mediated provision of T-cell receptor gamma delta (TCRγδ) expressing cells contributes to improving antileukemic reactions ex vivo

T-cell receptor gamma delta (TCRγδ) expressing T-cells are known to mediate an MHC-independent immune response and could therefore qualify for immune therapies. We examined the influence of dendritic cells(DC)/antigen presenting cell (APC) generated from blast-containing whole blood (WB) samples from AML and MDS patients on the provision of (leukemia-specific) TCRγδ expressing T-cells after mixed lymphocyte culture (MLC). Kit-M (granulocyte-macrophage colony-stimulating factor (GM-CSF) + prostaglandin E1 (PGE1)) or Kit-I (GM-CSF + Picibanil) were used to generate leukemia derived APC/DC (DCleu)from WB, which were subsequently used to stimulate T-cell enriched MLC. Immune cell composition and functionality were analysed using degranulation- (DEG), intracellular cytokine- (INTCYT) and cytotoxicity fluorolysis- (CTX) assays. Flow cytometry was used for cell quantification. We found increased frequencies of APCs/DCs and their subtypes after Kit-treatment of healthy and patients´ WB compared to control, as well as an increased stimulation and activation of several types of immune reactive cells after MLC. Higher frequencies of TCRγδ expressing leukemia-specific degranulation and intracellularly cytokine producing T-cells were found. The effect of Kit-M-treatment on frequencies of TCRγδ expressing cells and their degranulation could be correlated with the Kit-M-mediated blast lysis compared to control. We also found higher frequencies of TCRγδ expressing T-cells in AML patients´ samples with an achieved remission (compared to blast persistence) after induction chemotherapy. This might point to APC/DC-mediated effects resulting in the provision of leukemia-specific TCRγδ expressing T-cells: Moreover a quantification of TCRγδ expressing T-cells might contribute to predict prognosis of AML/MDS patients

Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation

Protein acetylation is a highly frequent protein modification. However, comparatively little is known about its enzymatic machinery. N-alpha-acetylation (NTA) and epsilon-lysine acetylation (KA) are known to be catalyzed by distinct families of enzymes (NATs andKATs, respectively), although the possibility that the sameGCN5-relatedN-acetyltransferase (GNAT) can perform both functions has been debated. Here, we discovered a new family of plastid-localizedGNATs, which possess a dual specificity. All characterizedGNATfamily members display a number of unique features. Quantitative mass spectrometry analyses revealed that these enzymes exhibit both distinctKAand relaxedNTAspecificities. Furthermore, inactivation ofGNAT2 leads to significantNTAorKAdecreases of several plastid proteins, while proteins of other compartments were unaffected. The data indicate that these enzymes have specific protein targets and likely display partly redundant selectivity, increasing the robustness of the acetylation processin vivo. In summary, this study revealed a new layer of complexity in the machinery controlling this prevalent modification and suggests that other eukaryoticGNATs may also possess these previously underappreciated broader enzymatic activities

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio