Assessment of Risk to Drinking Water from Turf Pesticide Runoff

A human health risk assessment was performed on pesticide runoff from lawns and golf courses for 9 U.S. locations using a fate and transport modeling program. Pesticide concentrations for 37 turf pesticides registered for application on golf courses were compared to drinking water standards. A maximum 24 hour lake pesticide concentration was used for an acute risk assessment and a mean daily lake concentration was used for a chronic risk assessment. Our results show that a number of the pesticides posed a potential risk as evidenced by a risk quotient (RQ; concentration divided by standard) over 0.01. For fairways, both iprodione and 24-D produced acute and chronic risk at more than 3 locations. Potential risk was only found for myclobutanil applications to greens and tees. MCPA, oxadiazon and 24-D applied to lawns posed both acute and chronic risks. The highest concentrations were seen with acephate applied to fairways with acute RQ≥0.01 in 4 locations and in oxadiazon applied to lawns in Houston with chronic RQ≥0.01. The assessment was based on simulations using TPQPond, a model developed for predicting pesticide runoff and resulting concentrations in a receiving pond, lake, or reservoir. The risk assessment followed general protocols used by USEPA in their pesticide concentration model, FIRST, but with more realistic methods of determining reservoir flow characteristics, pesticide mass balances and region specific weather data. Risk levels were found to vary with location and turf type. Pesticide concentrations were highest for fairways and lowest for greens. Greatest impacts were observed in areas of high annual precipitation rates and long growing seasons whereas lowest impacts were observed in areas of low precipitation rates. These results suggest that persons living in heavy rainfall areas may have higher exposures of turf pesticide in their drinking water than would be predicted by EPA risk assessments

That’s entertainment: trends in late-night assaults and acute alcohol illness in Sydney's entertainment precinct

Summary: This report uses various data sources to show the incidence of night-time alcohol-related violence and other alcohol harm in the Sydney CBD in the ten years prior to the 2014 lockout intervention. Between 2004 and 2013 police crime statistics and triple zero (000) calls both show a decrease in alcohol-related assault while emergency department presentations for alcohol illnesses increased.   Aim: To assess the role of administrative police and health databases in monitoring trends in, and epidemiology of, alcohol-related violence and acute alcohol illness associated with the night time economy in the Sydney central business district (CBD) "Entertainment Precinct", prior to the introduction of 2014 government reforms addressing "alcohol-fuelled violence". Method: We examined annual trends in police-recorded incidents of grievous bodily harm, ambulance Triple Zero (000) calls for assault, and acute alcohol illness emergency department presentations that occurred between 10 p.m. and 6 a.m. over a 10-year period (2004–2013). Trends were examined among persons of all ages and young adults (18 to 29 year olds) in the CBD. The rest of metropolitan Sydney provided a comparison area to evaluate whether trends were CBD-specific. Results: Among persons of all ages, there were 913 police-recorded incidents of grievous bodily harm, 10,427 ambulance calls for assault and 14,106 emergency department presentations for acute alcohol illness in the CBD over the 10-year period. Young adults accounted for between 62 per cent and 78 per cent of assault incidents and 58 per cent of alcohol emergency department presentations. Between 2004 and 2008, the annual number of assaults and acute alcohol illness increased two-fold. Alcohol illness emergency department presentation trends subsequently stabilised, while assaults in 2013 were at the lowest levels in 10 years. Similar trends were observed in the rest of metropolitan Sydney. Conclusion: The majority of alcohol-related assaults and emergency department presentations involved young adults. Ambulance and police administrative data sources provided a consistent picture of a recent decline in late-night assault trends. Alcohol-related emergency department presentation trends suggested other alcohol harms may be continuing at relatively high levels both in the CBD and in metropolitan Sydney. While violence appears to be declining in the CBD and across Sydney, continuing alcohol harm remains to be addressed. &nbsp

A Case of Initially Undiagnosed Chikungunya Arthritis Developing into Chronic Phase in a Nonendemic Area

This case report described a 40-year-old lady presented with fever, headache, arthralgia, myalgia, and impaired liver function after returning from the Philippines. Chikungunya virus (CHIKV) and dengue serology were negative. Eight weeks after initial presentation, she experienced inflammatory polyarthritis mimic rheumatoid arthritis. This time CHIKV-IgM was detected, together with a >4-fold rise of CHIKV-polyvalent-antibody titre. The first CHIKV-IgM negative sample was reexamined and was CHIKV-PCR positive. CHIKV infection was confirmed and diagnosis of CHIKV-related arthritis was made. A quarter of CHIKV infected individuals develop post-CHIKV rheumatisms that affect quality of life and may need treatment with Disease Modifying Antirheumatic Drugs. This case highlights the importance of considering CHIKV infection in patients present with symmetrical polyarthritis particularly after travel to endemic regions. Testing of both CHIKV acute and convalescent-phase serum for CHIKV antibodies and PCR is recommended in suspicious case

Contribution of hurricane-induced sediment resuspension to coastal oxygen dynamics

© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 15740, doi:10.1038/s41598-018-33640-3.Hurricanes passing over the ocean can mix the water column down to great depths and resuspend massive volumes of sediments on the continental shelves. Consequently, organic carbon and reduced inorganic compounds associated with these sediments can be resuspended from anaerobic portions of the seabed and re-exposed to dissolved oxygen (DO) in the water column. This process can drive DO consumption as sediments become oxidized. Previous studies have investigated the effect of hurricanes on DO in different coastal regions of the world, highlighting the alleviation of hypoxic conditions by extreme winds, which drive vertical mixing and re-aeration of the water column. However, the effect of hurricane-induced resuspended sediments on DO has been neglected. Here, using a diverse suite of datasets for the northern Gulf of Mexico, we find that in the few days after a hurricane passage, decomposition of resuspended shelf sediments consumes up to a fifth of the DO added to the bottom of the water column during vertical mixing. Despite uncertainty in this value, we highlight the potential significance of this mechanism for DO dynamics. Overall, sediment resuspension likely occurs over all continental shelves affected by tropical cyclones, potentially impacting global cycles of marine DO and carbon.Support for J. Moriarty was provided by the USGS Mendenhall Program

Visual search strategies during facial recognition in children with ASD

Facial recognition is a complex skill necessary for successful human interpersonal and social interactions. Given that the most prevalent disorder of social interaction is autism spectrum disorder (ASD), a number of studies have investigated and found impaired facial recognition abilities in people with ASD. Further, this impairment may be critically involved in mediating the deficits in interpersonal and social interactions in people with ASD. We sought to address the question of whether face processing is impaired in children with ASD in the current study. While there were a number of differences in visual search behaviours between the 19 children with ASD and the 15 controls, this did not manifest in deficits in facial recognition accuracy. In addition, there were notable differences with respect to eye fixation behaviours and recognition accuracy in this study compared to the findings in a previous similar study conducted in adults with ASD. These differences suggest a performance enhancing developmental trajectory in facial processing in controls that may not be present in individuals with ASD

Rethinking the difficult patient: Formative qualitative study using participatory theater to improve physician-patient communication in rheumatology

BACKGROUND: Effective physician-patient communication is crucial for positive health outcomes for patients with chronic diseases. However, current methods of physician education in communication are often insufficient to help physicians understand how patients\u27 actions are influenced by the contexts within which they live. An arts-based participatory theater approach can provide the necessary health equity framing to address this deficiency. OBJECTIVE: The aim of this study was to develop, pilot, and conduct a formative evaluation of an interactive arts-based communication skills intervention for graduate-level medical trainees grounded in a narrative representative of the experience of patients with systemic lupus erythematosus. METHODS: We hypothesized that the delivery of interactive communication modules through a participatory theater approach would lead to changes in both attitudes and the capacity to act on those attitudes among participants in 4 conceptual categories related to patient communication (understanding social determinants of health, expressing empathy, shared decision-making, and concordance). We developed a participatory, arts-based intervention to pilot this conceptual framework with the intended audience (rheumatology trainees). The intervention was delivered through routine educational conferences at a single institution. We conducted a formative evaluation by collecting qualitative focus group feedback to evaluate the implementation of the modules. RESULTS: Our formative data suggest that the participatory theater approach and the design of the modules added value to the participants\u27 learning experience by facilitating interconnection of the 4 communication concepts (eg, participants were able to gain insight into both what physicians and patients were thinking about on the same topic). Participants also provided several suggestions for improving the intervention such as ensuring that the didactic material had more active engagement and considering additional ways to acknowledge real-world constraints (eg, limited time with patients) in implementing communication strategies. CONCLUSIONS: Our findings from this formative evaluation of communication modules suggest that participatory theater is an effective method for framing physician education with a health equity lens, although considerations in the realms of functional demands of health care providers and use of structural competency as a framing concept are needed. The integration of social and structural contexts into the delivery of this communication skills intervention may be important for the uptake of these skills by intervention participants. Participatory theater provided an opportunity for dynamic interactivity among participants and facilitated greater engagement with the communication module content

MINER: exploratory analysis of gene interaction networks by machine learning from expression data

<p>Abstract</p> <p>Background</p> <p>The reconstruction of gene regulatory networks from high-throughput "omics" data has become a major goal in the modelling of living systems. Numerous approaches have been proposed, most of which attempt only "one-shot" reconstruction of the whole network with no intervention from the user, or offer only simple correlation analysis to infer gene dependencies.</p> <p>Results</p> <p>We have developed MINER (Microarray Interactive Network Exploration and Representation), an application that combines multivariate non-linear tree learning of individual gene regulatory dependencies, visualisation of these dependencies as both trees and networks, and representation of known biological relationships based on common Gene Ontology annotations. MINER allows biologists to explore the dependencies influencing the expression of individual genes in a gene expression data set in the form of decision, model or regression trees, using their domain knowledge to guide the exploration and formulate hypotheses. Multiple trees can then be summarised in the form of a gene network diagram. MINER is being adopted by several of our collaborators and has already led to the discovery of a new significant regulatory relationship with subsequent experimental validation.</p> <p>Conclusion</p> <p>Unlike most gene regulatory network inference methods, MINER allows the user to start from genes of interest and build the network gene-by-gene, incorporating domain expertise in the process. This approach has been used successfully with RNA microarray data but is applicable to other quantitative data produced by high-throughput technologies such as proteomics and "next generation" DNA sequencing.</p

Tap water perceptions and water filter use vary with sociodemographic characteristics and influence water consumption in university students

Abstract Objective The goal of this study is to evaluate university students’ perceptions of tap water safety and water filter use, and determine how these perceptions and behaviors affect water and sugar sweetened beverage intake. Design Cross-sectional; online survey conducted in Fall 2021. Setting A large, public Midwestern university in the United States Participants 793 undergraduate students Results Students who experienced food insecurity, were on a Pell grant, were first generation college students or were racial/ethnic minorities were less likely to trust tap water safety. Tap water filtration behavior also varied by age and race/ethnicity. Students who did not agree with the statement “my local tap water is safe to drink” had lower odds of consuming ≥3 cups of total water per day (OR=0.45, 95% CI: 0.32, 0.62), lower odds of consuming tap water ≥3 times/day (OR=0.46, 95% CI: 0.34, 0.64), higher odds of drinking bottled water ≥1 time per day (OR=1.80, 95% CI: 1.22, 2.66), and higher odds of drinking SSBs ≥1 time per day (OR=1.47, 95% CI: 1.01, 2.14) than those who agreed. Students who always or sometimes filtered their tap water had lower odds of consuming ≥3 cups of total water per day (OR=0.59, 95% CI: 0.39, 0.90) than students who never filtered their tap water. Conclusions Tap water perceptions and behaviors affect tap and bottled water and SSB intake among university students. Tap water perceptions and behaviors in this demographic provide important context for university programming promoting healthy beverage initiatives

A cost-effective and universal strategy for complete prokaryotic genomic sequencing proposed by computer simulation

Background: Pyrosequencing techniques allow scientists to perform prokaryotic genome sequencing to achieve the draft genomic sequences within a few days. However, the assemblies with shotgun sequencing are usually composed of hundreds of contigs. A further multiplex PCR procedure is needed to fill all the gaps and link contigs into complete chromosomal sequence, which is the basis for prokaryotic comparative genomic studies. In this article, we study various pyrosequencing strategies by simulated assembling from 100 prokaryotic genomes. Findings. Simulation study shows that a single end 454 Jr. run combined with a paired end 454 Jr. run (8 kb library) can produce: 1) ∼90% of 100 assemblies with 99.99%; 4) average false gene duplication rate is < 0.7%; 5) average false gene loss rate is < 0.4%. Conclusions: A single end 454 Jr. run combined with a paired end 454 Jr. run (8 kb library) is a cost-effective way for prokaryotic whole genome sequencing. This strategy provides solution to produce high quality draft assemblies for most of prokaryotic organisms within days. Due to the small number of assembled scaffolds, the following multiplex PCR procedure (for gap filling) would be easy. As a result, large scale prokaryotic whole genome sequencing projects may be finished within weeks. © 2012 Jiang et al; BioMed Central Ltd.published_or_final_versio