26 research outputs found

    肝腎症候群の成因の解明とその治療法の開発

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    金沢大学医学部研究課題/領域番号:X46120-----70043, 研究期間(年度): 1971出典:研究課題「肝腎症候群の成因の解明とその治療法の開発」課題番号 X46120-----70043(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X46120-----70043/)を加工して作

    糖尿病性腎症に関する実験的ならびに臨床的研究

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    金沢大学医学部研究課題/領域番号:X41440----720069, 研究期間(年度):1966出典:研究課題「糖尿病性腎症に関する実験的ならびに臨床的研究」課題番号X41440----720069(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X41440----720069/)を加工して作

    ネフローゼ症候群治療におけるステロイド抵抗性の本態の解明とその対策

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    金沢大学医学部研究課題/領域番号:X00080----848123, 研究期間(年度)1973出典:研究課題「ネフローゼ症候群治療におけるステロイド抵抗性の本態の解明とその対策 」課題番号 X00080----848123(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00080----848123/)を加工して作

    アルコール性肝障害の発生とその防止に関する研究

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    金沢大学医学部研究課題/領域番号:X44095-----87548, 研究期間(年度):1969出典:研究課題「アルコール性肝障害の発生とその防止に関する研究」課題番号 X44095-----87548(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-X44095-----87548/)を加工して作

    "圧受容器"としての腎の意義にかんする研究

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    金沢大学医学部研究課題/領域番号:X42440----720064, 研究期間(年度):1967出典:研究課題「"圧受容器"としての腎の意義にかんする研究」課題番号X42440----720064(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X42440----720064/)を加工して作

    尿細管障害の病態生理とその診断

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    金沢大学医学部研究課題/領域番号:X00120----787041, 研究期間(年度)1972 – 1973出典:研究課題「尿細管障害の病態生理とその診断 」課題番号 X00120----787041(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00120----787041/)を加工して作

    INTRAGLOMERULAR UPTAKE OF PLATELETS IN UNILATERAL MASUGI NEPHRITIS IN THE RABBIT

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    The pathogenetic roles of platelets were studied in unilateral progressive Masugi nephritis in the rabbit. On fourteenth day after the injection of anti-kidney serum, peripheral platelet counts, platelet aggregation and platelet aggregation rate were not changed statistically compared with those before the initial injection. The presence of platelet antigen within the glomeruli of the unclamped nephritic kidney suggests the participation in the pathogenesis of glomerular lesion. No significant difference was observed in the intrarenal uptake of 111Indium-labeled platelets between clamped and unclamped kidneys. This is probably due to the possibility of the participation of the very small amount of platelets or the possible decreased renal blood flow in the nephritic side in this model, or the active uptake of platelet not being found in this progressed stage of this model

    THE USE OF EVOKED ENDOCARDIAL RESPONSE FOR ASSESSMENT OF ANTIARRHYTHMIC DRUG EFFECTS ON MYOCARDIUM

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    The technique “asymmetric biphasic stimulation” which paces the heart and neutralizes the post-stimulus polarization at the electrode-tiessue interface allows for the recording of the entire evoked endocardial response via a single electrode for both pacing and recording. Using this system the effects of antiarrhythmic drugs, procainamide and N-acetylprocainamide, on the myocardium were studied in 20 dogs. Before and during the five step drug infusion, the evoked endocardial responses were recorded during bipolar and unipolar at the rates of 120, 150 and 200/min. The plasma concentration of the procainamede ranged from 1.7 to 32.5 mg/l and that of N-acetylprocainamide ranged from 8.1 to 116.l mg/l. Procainamied significantly prolonged both the depolarization duration and the repolarization duration at a low plasma concentration (Class I antiarrhythmic drug property). N-acetylprocainamide significantly prolonged the repolarization duration at a low plasma concentration, while the depolarization duration was not significantly changed at a low or therapeutic plasma concentration (Class III antiarrhythmic drug property). The prolongacion of the depolarization duration by procainamide and N-acetylprocainamide was rate-dependent; the faster the rate the greater the prolongation. This simple and accurate assessment of the antiarrhythmic drug effects on the myocardium may provie a future means for the pharmacologic antiarrhythmic therapy
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