6 research outputs found
Detecção sorolĂłgica do vĂrus A da videira em vinhedos do Estado de SĂŁo Paulo
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- 'FapUNIFESP (SciELO)'
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No full textIdentidade do Apple stem pitting virus em SĂŁo Paulo, Brasil, confirmada por meio de RT-PCR
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
No full textDetecção por DAS-ELISA do Apple chlorotic leaf spot virus em pétalas desidratadas de macieira mantidas em geladeira por 16 anos
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
No full textEmpagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial
- Author
- Abu Hassan M.
- Adawi F.
- Adojaan B.
- Agafyina A.
- Aguilar-Salinas C.
- Agung P.
- Ahmad N. Nik
- Aiello A.
- Aizenberg D.
- Ajani D.
- Al-Windy N.
- Allemant Maldonado A.
- Aloi J.
- Alpizar Salazar M.
- Alzohaili O.
- Amod A.
- Andersen J.
- Anderson M.
- Andrade L.
- Anspach R.
- Antoli A.
- Antonypillai C.
- Aquitania G.
- Aravind S.
- Arca M.
- Arena C.
- Arif A.
- Aronoff S.
- Artola S.
- Arutyunov G.
- Aure P.
- Austin B.
- Avramidis I.
- Awad A.
- Ayoub J.
- Badgandi M.
- Balasko A.
- Balic S.
- Ball E.
- Bantwal G.
- Barager W.
- Baranowski M.
- Barbarash O.
- Barbarich V.
- Barbonta D.
- Barker B.
- Bashkin A.
- Bayly K.
- Belenkiy D.
- Benatar J.
- Benhalima Katrien
- Benroubi M.
- Bergenstal R.
- Bergman B.
- Berlingieri J.
- Bertolami M.
- Berz A.
- Betti R.
- Bittar N.
- Blakney E.
- Blaze K.
- Blignaut S.
- Boesgaard T. Wellov
- Bononi P.
- Borges J.
- Boscia J.
- Boucher P.
- Bousboulas S.
- Bowden R.
- Boyarkin M.
- Brandon D.
- Bratcher C.
- Brazao M.
- Bressler P.
- Breton C.
- Bretton E.
- Brito M.
- Brockmyre A.
- Broedl Uli C.
- Brusco O.
- Bucci M.
- Bulugahapitiya D.
- Burgess L.
- Burr R.
- Burtchuladze T.
- Butler M.
- Buynak R.
- Bystrova A.
- Cahill T.
- Calabro P.
- Caldwell I.
- Camafort M.
- Capiau L.
- Cardona Munoz E.
- Castro M.
- Catrinoiu D.
- Cefalu W.
- Chachati A.
- Chacra A.
- Chan Y.
- Chandramouli A.
- Chang H.
- Chang K.
- Chappell D.
- Chauhan A.
- Chaykin L.
- Chee K.
- Chehayeb R.
- Chen J.
- Cherlin R.
- Chiang C.
- Choksi M.
- Choukroun G.
- Christensen P.
- Christensen T.
- Chumakova G.
- Cignarelli M.
- Clavel S.
- Clayton D.
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- Colombo H.
- Connery L.
- Cosma D.
- Couffinhal T.
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- Crisan C.
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- De Loredo L.
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- de Teresa L.
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- Zwiers G.
- Publication venue
- Publication date
- 01/01/2018
- Field of study
No full textEzetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
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- Ahsan A
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- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
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- Zanolin D
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- Zweiker R
- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
Get PDFBACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit
