7 research outputs found
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
- Author
- Abarca Javiera
- Abarca Luis
- Abdlaziz Ihab
- Abraham Valsamma
- Accetta Riccardo
- Adhye Bharati Anil
- Adili Anthony
- Adinarayanan S
- Aframian Arash
- Aguado Hector J
- Aguilar Marc
- Ahmed Tashfeen
- Ahn Henry
- Ali Arif
- Almas Ayesha
- Alvarado Kim A
- Ambroży Wojciech
- Anaya Rafael
- Andres-Peiro Jose-Vicente
- Anjum Anila
- Arnuntasupakul Vanlapa
- Arroyo Marta
- Ashraf Mohammed
- Ashraf Muhammad
- Atrey Amit
- Avram Victoria RA
- Balaguer-Castro Mariano
- Balasubramanian Kumar
- Balonov Konstantin
- Bangdiwala Shrikant I
- Bardana Davide D
- Barnawal Satish Prasad
- Bartley Debra
- Baños Victoria
- Beaupre Lauren
- Begum Dilshad
- Belley-Cote Emilie P
- Bentoumi Souad
- Beretta Luigi
- Bergese Sergio D
- Bernaus Martí
- Beroud Sebastien
- Bhandari Mohit
- Bhutia Jigme Tshering
- Biccard Bruce M
- Bicknell Ryan T
- Bidkar Prasanna Udupi
- Bilchod Prashanth Nabhirajappa
- Binda Mirko
- Biscardi Anna
- Bisland Stuart
- Bogallo Jose Manuel
- Bohm Eric R
- Bokhari Syedah Saira
- Bonadies Marika
- Boon Huck Wee
- Borate Madhav Pandurang
- Borges Flavia K
- Brokelman Roy B.G.
- Campbell Aaron R
- Campbell Ryan Jonathan
- Cano Juan Ramon
- Carey Timothy
- Carreras-Castañer Anna
- Cassidy Charles
- Castillón Pablo
- Cecconi Maurizio
- Chalacheewa Theerawat
- Chandran Nitheesh
- Chaudier Philippe
- Chaw Sook Hui
- Chee KH
- Chen Brian P-J
- Chetty Sean
- Chin Im Im
- Choi Stephen
- Chouhan Devendra K
- Clark Molly E
- Clinckaert Carol
- Cobben Jan-Hein MG
- Coles Chad P
- Colnaghi Eleonora
- Colombo Chiara
- Colomina Maria J
- Comstock Curt
- Conen David
- Cornu Olivier
- Correia Patricia
- Coughlin Ryan
- Coupal Stephanie A
- Cowan David D
- Crawford Gordon A
- Cruz Encarnacion
- Cullinan Claude
- Cámara-Cabrera Jaume
- Daniels Timothy R
- Dashputra Ravi Prabhakar
- David Jean Stephane
- de Beer Justin
- De Blasio Giuseppe
- De Caso Julio
- De Clippeleir Dirk
- Dealbert Alfred
- Deheshi Benjamin
- Dehghan Niloofar
- Denaro Giuseppe
- Devereaux PJ
- Dhillon Mandeep S
- Dillane Derek
- Dillingham Sally
- Ding Anthony
- Dongre Himanshu Vijaykumar
- Douplat Marion
- Dragic-Taylor Sanela
- Dresser George K
- Droll Kurt
- Duncan Andrew W
- Dąbek Piotr
- Elnaggar Mohamed
- Elskamp-Meijerman Hannie F
- Estrada Cristina
- Fang Christian Xinshuo
- Farooque Kamran
- Farrell Janet C
- Fayet Jean Marie
- Feibel Robert J
- Feijoo-Massó Carlos
- Fergusson Dean A
- Fessy Michel Henri
- Firth Gregory Bodley
- Flikweert Elvira R
- Flint Margot
- Foo Li Lian
- Forget Patrice
- Fourtounas Maria
- Fozzato Stefania
- Fraguas-Castany Antoni
- Frank Christopher C
- Friggeri Arnaud
- Furgan Ahmad
- Gallant Catherine
- Gamangati Shivanand
- Garcia-Sanchez Yaiza
- Garg Amit X
- Garrido Clua Miriam
- Gattu Uttam Vaidya
- Gauthier Leslie P
- George Carolin Elizabeth
- George Preetha Elizabeth
- Georgekutty AM
- Giardina Giuseppe
- Giilck Stephen M
- Gnanadurai Kingsly Robert
- Gonzalez Posada MA
- Gonzalez Zacarias Alicia A
- Grant Heather
- Greene James
- Gregus Krysten K
- Grzelak Adrian
- Gucwa Jaroslaw
- Guerado Enrique
- Guerra-Farfan Ernesto
- Guilabert Patricia
- Gupta Babita
- Guy Pierre
- Guyatt Gordon H
- Guzzetti Luca
- Gómez Olga
- Hadden William J
- Haider Syed Y
- Haire Kevin
- Hall Jeremy A
- Halman Samantha
- Harrison Mark M
- Harvey Valerie
- Hashmi Pervaiz Mehmood
- Henry Patrick DG
- Herranz Susana
- Herrera-Mateo Sergio
- Higa-Sansone JL
- Hiremath Santosh Angad
- Horst Maarten R
- Hunt Stephen B
- Hupel Tom
- Imbuldeniya Arjuna
- Iqbal Muhammad Nasir
- Irwin Marleen
- Ivanov Alexia
- Jacka Michael J
- Jaeger Melanie T
- Janjua Kholood Abid
- Jawali Abhijit
- Jenkinson Richard J
- John Bobby
- John Joby
- Jornet-Gibert Monsant
- Joseph Katherine
- Joseph Philip G
- Juman Naveed Muhammed
- K Varghese Zachariah
- Kadry Miriam Adel
- Karbassi Arsha
- Karera Mwalimu
- Kearon Clive
- Khan Abdus Salam
- Khan Eraj Khurshid
- Khan Hammad Naqi
- Khan Moin
- Khan Muhammad Kashif
- Khan Robyna Irshad
- Khan Siddra Ahmed
- Khanna Vickas
- Khattak Mujahid Jamil
- Khor HM
- Khoshbin Amir
- Kishta Waleed
- Kleinlugtenbelt Ydo V
- Koo Kevin
- KP Mary KP
- Kreder Hans J
- Kudrimoti Kiran Bhalchandra
- Kulachote Noratep
- Kumar CS
- Kumoń Adam
- Kunz Monica R
- Labrador Gregorio
- Lai Hou Yee
- Lakdawala Riaz Hussain
- Lal Purushotham
- Lalueza-Broto Pilar
- Lamy Andre
- Landais Paul
- Landman Ellie BM
- Landoni Giovanni
- Lavand'homme Patricia
- Lawendy Abdel-Rahman
- Lawrence Kelly H
- Le Manach Yannick
- le Polain de Waroux Bernard
- Lee Jacques S
- Lee Meng-Li
- Lefrancois Tina
- Leong Darryl P
- Leung Frankie Ka Li
- León Ricardo
- Liu Yang
- Loh PS
- Louboutin Lucie
- M Niranjan
- MacDonald Anne Marie
- MacDonald Shelley
- Machala Waldemar
- Macho Oscar
- Macleod Mark D
- Maddipati Tatarao
- Magloire Patrick
- Malhotra Rajesh
- Maluleke Matimba Lenny
- Mann Stephen M
- Maqungo Sithombo
- Marcantonio Andrew J
- Marcato Anna
- Marcucci Maura
- Marion Travis
- Marmor Meir T
- Martin Nuria
- Martinez-Municio Gonzalo
- Martinez-Ripol Pedro
- Martínez-Sañudo Luis
- Mateo Llorenç
- Mathur Purva
- Matityahu Amir
- Maxwell Chelsea
- Mayor Amy SE
- McClellan Robert Trigg
- McGillion Michael H
- McIlquham Katie
- McLean Lisa M
- McMahon Stephen J
- Menon Jagdish
- Menon Matthew
- Menon Prem Haridas
- Mestre-Torres Jaume
- Millan Angelica
- Minguell-Monyart Joan
- Mishra Sandeep Kumar
- Mittal Samarth
- Molero-Garcia Vicente
- Moller Carien
- Molnar Sarah
- Moppett Iain K
- Morelli Ilaria
- Mozzon Lise
- Mustafa Khawaja Junaid
- Muñoz Juan Manuel
- Naidoo Rubendren
- Nam Diane
- Nanjayan Shashi Kumar
- Naratreekoon Bundit
- Narayan Ravi
- Nauth Aaron
- NC Madhusudhan
- Neary John D
- Nejthardt Marcin B
- Ngim Joanne HL
- Nhlapo Lerato
- Nicholson Laura
- Noordin Shahryar
- Nousiainen Markku
- Novellas Marga
- Nur Aamer Nabi
- Nuñez Camarena Jorge
- O'Brien Peter J
- O'Sullivan Susan
- O'Toole Robert
- Olivieri Loretta
- Omran Sherif
- Orakzai Sajjad Hassan
- Oxner William
- Oyenubi Ademilola N
- Pandey Ritesh Arvind
- Parker Martyn J
- Patel Ameen
- Patil Atul Ashok
- Patil Sharanu
- Patil Shashank
- Payendeh Jubin
- Paños Gozalo M Luisa
- Peig-Font Anna
- Pengrung Nachapan
- Perazzo Paolo
- Pettit Shirley M
- Pey Borja
- Phieffer Laura S
- Piccirillo Fabio
- Pino Fabio
- Piriou Vincent
- Placella Giacomo
- Ploeg Leone
- Popova Ekaterine
- Porcel-Vazquez Juan A
- Pradhan Chetan Vijay
- Prakasam Komella
- Puram Chetan Prabhakar
- Puskas David
- Quintas Saioa
- Quraishi Faraaz A
- Rahate Prashant Vitthal
- Rajkumar Arti
- Ramokgopa Mmampapatla T
- Ramokgopa Mmampapatla Thomas
- Rashid Haroon Ur
- Rashid Rizwan Haroon
- Ravi Bheeshma
- Reul Maike
- Riaz Muhammad Mehmood
- Richardson C Glen
- Ricol Laura
- Roerdink Herbert W
- Ruggiero Sara
- Ryan Scott P
- Rycombel Jacek
- Sa-ngasoongsong Paphon
- Sadoughi Mehdi
- Salini Vincenzo
- Salomó-Domènech Mònica
- Salvador Jordi
- Sancheti Parag K
- Sancheti Parag Kantilal
- Sanchez-Raya Judith
- Sanders David W
- Santiago-Maniega Silvia
- Santone David J
- Satora Wojciech
- Sawhney Chavi
- Schemitsch Emil
- Schemitsch Emil H
- Sciadini Marcus
- Selga Marsa Jordi
- Serrano-Sanz Jorge
- Shadowitz Steven
- Shan Lei
- Shanthanna Harsha
- Sharma Achal
- Sharma Deep
- Sharma Vijay
- Shirali Hemant R
- Shiraz Muhammad
- Shrikumar Mopina
- Sianes-Gallén Mònica
- Sigamani Alben
- Sigamani Alen
- Simpson Diane L
- Singh Simmrat
- Singh Surya Udai
- Singh Virsen
- Sirisreetreerux Norachart
- Sivilotti Marco LA
- Slobogean Gerard
- Smith Christopher A
- Smith Crystal A
- Sohail Mian Amjad
- Stella Daniele
- Stephen David JG
- Stephen Manesh
- Stiegelmahr Robert
- Sulthan Ahamad Shaheel
- Swaminathan Srinivasan
- Szczeklik Wojciech
- Tan Kit Mun
- Tandon Vikas
- Teixidor-Serra Jordi
- Thayaparan Surendini
- Thiruganasambandamoorth Venkatesh
- Tiboni Maria E
- Tieszer Christina
- Tomas-Hernandez Jordi
- Toogood Paul
- Torner Pere
- Torra Mercè
- Touil Nassim
- Tran Sarah
- Trask Kelly
- Trenholm J Andrew I
- Tribak Karim
- Tripathy Vijaylaxmi
- Tuazon Ravianne
- Turgeon Thomas R
- Turiel Maurizio
- Tushinski Daniel M
- Umar Muhammad
- Umer Masood
- Usua Gemma
- Valldosera Esther
- Vasarhelyi Edward
- Veevaete Laurent
- Villar-Casares Maria del Mar
- Vincent Jessica
- Vizcaychipi Marcela Paola
- Wahab Hussain
- Wang Chew Yin
- Ward Sarah E
- Wasserstein David
- Watts Evan
- Wells Jennifer R
- Whelan Daniel B
- White Neil J
- Whitlock Richard
- Wikkerink Spencer
- Wilson David AJ
- Winemaker Mitchell
- Wong Steven CW
- Wood Gavin CA
- Wood Thomas J
- Worster Andrew
- Wright Douglas Steven
- Wu Anshi
- Yach Jeff D
- Yee Allan J
- Yee Dennis King Hang
- Yela-Verdú Christian
- Yingchoncharoen Teerapat
- Yombi Jean Cyr
- Yuste Antoni
- Yusuf Salim
- Zabalza Ana
- Zaki Amna
- Zhao Yanrui
- Zhou Junlin
- Ślęczka Paweł
- Święch Mariusz
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/02/2020
- Field of study
Data Science Analysis and Profile Representation Applied to Secondary Prevention of Acute Coronary Syndrome
- Author
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/01/2021
- Field of study
The analysis of large amounts of data from electronic medical records (EMRs) and daily clinical practice data sources has received increasing attention in the last years. However, few systematic approaches have been proposed to support the extraction of the wealth and diversity of information from these data sources. Specifically, Acute Coronary Syndrome (ACS) data are available in many hospitals and health units because ACS shows elevated morbidity and mortality. This work proposes a method called Data Science Analysis and Representation (DSAR) to scrutinize and exploit, in a univariate way, scientific information content in limited ACS samples. DSAR uses Bootstrap Resampling to provide robust, cross-sectional, and non-parametric statistical tests on categorical and metric variables. It also constructs an informative graphical representation of the database variables, which helps to interpret the results and to identify the relevant variables. Our objectives were to validate DSAR by comparing it to conventional statistical methods when looking for the most relevant variables in the secondary prevention of ACS, and to determine the degree of correlation between them and the Exitus event (associated with patient death). To achieve this objective, we applied DSAR on an anonymized sample of 270 variables from 2377 patients diagnosed with ACS. The results showed that DSAR identified 44% significant variables while conventional methods offered weak correlation results. Then, the scientific literature was reviewed for a set of these variables, validating the agreement with clinical experience and previous ACS research. The conclusion is that DSAR is a valuable and a useful method for clinicians in the identification of potentially predictive variables and, overall, a good starting point for future multivariate secondary analyzes in the clinical field of ACS, or fields with similar information characteristics
Toxicity of prolonged treatment with eribulin (E) in metastatic breast cancer (MBC) patients: Results of the EXTER study.
- Author
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Ababneh Hazim
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abbo Olivier
- Abbott Tom
- Abd Elwahab Sami
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala'a
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abukhalaf Sadi A.
- Abuleil Amro
- Achalandabaso Boira Mar
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguiar Junior Samuel
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Alberdi San Roman Igor
- Albertsmeier Markus
- Alcaraz Fuentes Marta
- Alderazi Amer
- Aldressi Wafa
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alonso Mendoza Veronica
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Andre Benoit
- Andres Calvache Jose
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aqeelah Ahmed
- Aqil Sabra
- Arevalo Sandoval Danilo Alfonso
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Ataide Gomes Gustavo Mendonca
- Atnafu Bahru
- Aviles Jimenez Pablo Mijahil
- Awad Selmy
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Azevedo Jose
- Azevedo Jose
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baia Catarina
- Bains Lovenish
- Baiocchi Glauco
- Bajaj Ankur
- Balanta-Melo Julian
- Baliarsing Lipika
- Ball Alasdair
- Ballouhey Quentin
- Bankhead-Kendall Brittany
- Barillas Sabrina
- Barker John
- Barrena Lopez Cristina
- Barros Aldo Vieira
- Basu Somprakas
- Batista Sylvia
- Behzadi Abdollah
- Bekele Kebebe
- Bele Uros
- Bele Uros
- Bella Romera Susana
- Ben Amer Anass
- Ben Jouira Rayet al Islam
- Benson Ruth
- Bergeat Damien
- Bertrand Marta
- Bescos Coro
- Betalleluz Pallardel Jenner
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Biccard Bruce
- Blanco-Colino Ruth
- Boccalatte Luis
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bolivar Saenz Dinimo
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Bouche Pierre-Alban
- Boucher Sophie
- Bouhuwaish Ahmad
- Branquinho Rita
- Brar Amanpreet
- Breen Kerry
- Bright Tim
- Brown Wendy
- Brunaud Laurent
- Brunner Stefan M.
- Buarque Igor
- Buarque Igor Lima
- Bucyibaruta Georges
- Bukhari Syed Imran
- Burgan Dania
- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- Cabanero Sanchez Alberto
- Caiado Andre
- Caicedo Lina
- Caja Vivancos Patricia
- Cal Fernando Bonilla
- Calderon Arancibia Jose Alfredo
- Calvo Espino Pablo
- Canals Sin Ma Pilar
- Canno Velasco Jorge
- Cappeliez Serge
- Cardenas Puiggros Laura
- Cardoso Paulo
- Carlos Bernal-Sprekelsen Juan
- Carpio Colmenares Yahaira Tatiana
- Carrasco Prats Milagros
- Carrera Jacqueline
- Carreras-Castaner Anna
- Caruana Edward
- Castell Gomez Jose Tomas
- Catala Bauset Juan Carlos
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Navneet Kumar
- Chebaro Alexandre
- Chew Min Hoe
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
- Christensen Peter
- Chuan Alwin
- Chwat Carina
- Clancy Cillian
- Colas-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Corella Fernando
- Corripio-Sanchez Ramon
- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cox Daniel
- Creavin Ben
- Crego Vita Diana
- Cretolle Celia
- Cristina Rahy-Martin Aida
- Croghan Stefanie M.
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- D'Aulerio Giuliana
- Dajti Irida
- Daoud Hassan
- Davis Niall
- Dawson Amanda Caroline
- Dawson Brett E.
- De Andres-Asenjo Beatriz
- de Dieu Haragirimana Jean
- De Simone Belinda
- Degefa Eyueal
- Delgado Fernandez Juan
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- des Deserts Marc Danguy
- Desai Anant
- Deus Ana Claudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Diaz Martinez Eneida
- Diaz-Feijoo Berta
- Diego Garcia Lucia
- Diez Alonso Manuel
- Dimofte Mihail-Gabriel
- Dione Sacdalan Marie
- do Amaral Campos Heloisa Galvao
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duprat Neto Joao Pedreira
- Duran Sanchez Iran Irani
- Duran Irani
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Earley Helen
- Eberbach Helge
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Ekenze Sebastian
- Ekiti Ido
- El-Boghdadly Kariem
- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Emile Sameh
- Enjuto Diego
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espinosa-Bravo Martin
- Estaire Gomez Mercedes
- Evans Jonathan
- Evelyn R Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Falcon Pacheco Glenda Marina
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faustin Ntirenganya
- Fernandez Coimbra Felipe Jose
- Fernandez Martin Maria Teresa
- Fernandez Martinez Daniel
- Fernandez-Lopez Antonio-Jose
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Fotopoulou Christina
- Fowler Alexander
- Fredon Fabien
- Freiria Eiras Miguel Angel
- Fuentes Tyare
- Fujimoto Yuki
- Futaba Kaori
- Gahwagi Milad
- Gallo Gaetano
- Ganly Ian
- Garcia De Cortazar Unai
- Garcia Escudero Damian
- Garcia Laura Saura
- Garcia Soria Vanesa
- Garcia-Adamez Jorge
- Garcia-Montoya Oscar-Julian
- Gaujoux Sebastien
- Gavalda Pellice M. Teresa
- Gebreyohanes Mengistu
- Gempt Jens
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gil-Sala Daniel
- Ginghina Octav
- Girard Edouard
- Girard Noemie
- Gjata Arben
- Glasbey James C.
- Glasbey James C.
- Glowka Tim R.
- Gohar Muhammad
- Gomez Fernandez Laura
- Gomez Perez Beatriz
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez-Suarez Susana
- Gourlay Ralph
- Gousias Konstantinos
- Gouvas Nikolaos
- Grama Florin
- Griffiths Ewen
- Gronchi Alessandro
- Groot Gary
- Gross Jefferson
- Gujjuri Rohan R.
- Gulla Aiste
- Gupta Anand
- Gupta Rahul
- Gut Anna Eleonora
- Gutierrez Perdomo Valentina
- Gutierrez Ruiz Alitza
- Ha Jeong
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Haidar Hanan
- Haider Fayza
- Hailu Samuel
- Hailu Samuel
- Hakami Ibrahim
- Hamad Faten Reyad Bani
- Hamdun Intisar Hisham Said
- Hameed B. M. Zeeshan
- Haran Cheyaanthan
- Harper Luke
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Heredia Fernando
- Heriot Alexander
- Hervieux Erik
- Herzberg Jonas
- Hilmi Ahmed
- Hirschburger Markus
- Hodgson Russell
- Hoehn Philipp
- Hollington Paul
- Horch Raymund E.
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Husain Shatha
- Hutchinson Peter
- Hyman Gabriella Yael
- Ikele Hilary
- Imanishimwe Alphonsine
- Incorvia Joseph
- Ingabire Jc Allen
- Ionescu Sebastian
- Isik Arda
- Iskander Othman
- Jain Kavitha
- Jain Ritu
- Jamal Mohammad
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
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- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdoun Meriem
- Abdur-Rahman Lukman
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- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
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- Abu Salhiyeh Ala A.
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abuawad Carla
- Abukhalaf Sadi A.
- Abuleil Amro
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agarwal Ketan
- Agastra Ervis
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguilera-Arevalo Maria-Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmadi Navid
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Aiken Taylor
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
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- Al Ameer Ahmed
- Al Amri Abdulrahman
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- Alajalen Amer
- Alalawi Yousef
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- Alawneh Yazan
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- Aldlyami Ehab
- Aldressi Wafa
- Alecci Anna
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhassoun Turki
- Alhefdhi Amal
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- Alkaseek Akram
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- Allemand Carola
- Almabayev Ydyrys
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- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
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- Alonso Manuel Diez
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- Alqudah Majdi Ali
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- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
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- Alyami Mohammad
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- Alzerwi Nasser
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- Amnaina Mohamed
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- Angeles Martina Aida
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- Anyanwu Lofty-John
- Aouabed Nesrine
- Aqeelah Ahmed
- Aqil Sabra
- Arancibia José Alfredo Calderón
- Arango Maria Clara Mendoza
- Arbane Gill
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
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- Asif Muhammad
- Assefa Melatework
- Atnafu Bahru
- Aulerio Giuliana D.
- Aurora
- Awad Selmy
- Ayasra Faris
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- Ayoub Abdu
- Ayub Bushra
- Ayub Khurram
- Azevedo José
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- Bezabih Yoseph Solomon
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- Bianco Agustín
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- Blasco Laura Sánchez
- Boccalatte Luis
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- Boira Mar Achalandabaso
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bollano Enton
- Bonci Eduard-Alexandru
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- Borda-Luque Giuliano
- Boretto Jorge G.
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Botero Marcela Velez
- Bouaoud Souad
- Bouche Pierre-Alban
- Bouchenak Kamel
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- Brar Amanpreet
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- Buarque Igor Lima
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- Efetov Sergey
- Egoroff Natasha
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- Ekenze Sebastian
- El Helw Amin
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- Glasbey James C.
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- Löffler Markus W.
- Lucchini Sergio Martin
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- Mclean Kenneth A.
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- McNestry Catherine
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- Meelad Ayman
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- Mengesha Mengistu G.
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- Olivos Maricarmen
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- Olson Kristofor A.
- Omar Omar M.
- Omari Rand Y.
- Oosterlinck Wouter
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- Oscco Regina Amparo Ugarte
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- Perez Rivera Carlos J.
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- Pilar Tormos Pérez M.
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- Porumb Vlad
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- Prada Jorge
- Pramesh C. S.
- Prat-Ortells Jordi
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- Qasem Abdulrahman
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- Qureshi Ahmad Uzair
- R Casadei
- Ra'ed Hazim
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- Ranganath N.
- Rasoaherinomenjanahary Fanjandrainy
- Rassweiler-Seyfried Marie-Claire
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- Reinke Caroline
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- Rennie Sarah
- Rice Henry E.
- Rice Henry E.
- Rida Ahmed Hossam Eldin Fouad
- Rio Javier
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- Saad Mahmoud M.
- Saadi Jose
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- Sikakulya Franck K.
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- Silva Nelson
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- Simoes Joana Ff
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- Stavrou Gregor A.
- Steinkamp Pieter
- Steinkamp Pieter
- Stephens Matthew
- Stevens Sean
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- Stijns Jasper
- Stoleriu Mircea Gabriel
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- Tan Lorwai
- Tariq Aiman
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- Taylor Elliott H.
- Teague Rebecca
- Teasdale Ella
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- Tejero-Pintor Francisco J.
- Tendeng Jacques
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- Trout Isobel M.
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- van Ramshorst Gabrielle
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- Varghese Chris
- Varghese Chris
- Varghese Chris
- Vartanian Jose Guilherme
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- Velasquez Enrique Jose Ruiz
- Venkatappa Sunil Kumar
- Venn Mary L.
- Verhaeghe Romain
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- Vidal Rafael Perez
- Vidya Raghavan
- Vijayakumar Vijayakumar M.
- Villanueva Julio
- Vimalakanthan Thanusan
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- Vives Josep Maria Muñoz
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- von Pusch Silke
- Vrapi Enxhi
- Vázquez Irene Ortega
- Wafi Omar
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- Waqar Shahzad Hussain
- Watson David
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- Wuraola Funmilola
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- Xaviour Okedi Francis
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Yip Sebastian Shu
- Youssef Mina
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zanoni Gerardo
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- Zarour Ahmad
- Zarour Ahmad
- Zarour Ahmad
- Zarratea Celeste Soledad
- Zegarra Sergio
- Zequi Stenio C.
- Zezular Damaris Idara Anabel
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zijaj Lorena
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Zohra Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Recommended from our members
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
- Bashour Jennifer
- Batteiger Teresa A.
- Baudelaire Clarisse
- Bazan Jose A.
- Becerra Maria G.
- Becker Teresa
- Beckmann David
- Bedimo Roger J.
- Belhorn Linda R.
- Benavides Alfredo Gilberto Guerreros
- Beninati Genevieve
- Benitez Jorge A.
- Bennett Annette R.
- Bennett Elizabeth
- Beresnev Tatiana
- Berman Megan
- Bermudez Maria I.
- Bernard Marcia
- Bernstein David I.
- Berry Andrea
- Berry Jennifer
- Berthaud Vladimir
- Bialobok Kristin
- Billings Joanne L.
- Bittner Zachary
- Blevins Jeanne
- Blumenthal Jill
- Boas Rebecca
- Bocchini Joseph
- Bold Tyler D.
- Bondell Alison
- Bondy Paul
- Borger Judith
- Borgetti Scott
- Boscia Joseph
- Boswell Dean M.
- Bourgeois Tana
- Bowers Maggie
- Bradley Paul S.
- Brady Judith
- Brakema Riemke
- Bran Andres
- Branche Angela R.
- Brandenburg Boerries
- Brandon Donald M.
- Bravo Eric
- Briskin Toby
- Broder Gail
- Brosz Adam B.
- Browder David
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- Burch Cortney
- Burgett Michelle L.
- Burgher Abram
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- Cannon Kevin D.
- Cantos Valeria D.
- Carmody Ellie
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- Carsons Steven E.
- Carvajal Marianela
- Casey Denise
- Caso Jorge
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- Castellon Marvin
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- Chadwick Mesha M.
- Chamberlain Amy
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- Choquette Karin
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- Clarence B. Creech I I
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- Cruz-Valdez Aurelio
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- Shankaran Shivanjali
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- Sheth Neil P.
- Shinn Steven
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- Shope Timothy
- Shopsin Bo
- Shoptaw Steven
- Siddiqui Farhan
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- Sims Matthew D.
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- Singletary Justin
- Skipper Stephanie
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- Smith William B.
- Snell Kimberly
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- Sobieszczyk Magdalena E.
- Sogbetun Obiageli
- Solis Joel
- Sonnier Cora
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- Spector Stephen A.
- Sperber Steven
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- Stanford Amber
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- Starlin Richard
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- Steil Kenneth
- Stephenson Carolene
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- Sterling Stephanie
- Stewart Brittany
- Striker Robert
- Strout Cynthia Becher
- Struyf Frank
- Studdard Suzanna
- Stulken Laura
- Stull Mildred
- Sturgeon Rodney E.
- Suen May-Yin
- Sugimoto Danny
- Suyehira Janice
- Swaminathan Shobha
- Swan Suzanne
- Swann Edith
- Swanson Austin
- Sweet Christy
- Swieboda Elisa
- Syndergaard Scott N.
- Takizala Zudi-Mwak
- Takuva Simbarashe G.
- Talaat Kawsar R.
- Tan Chen S.
- Tapia Milagritos
- Tarakjian Denis
- Tashima Karen
- Tatelbaum David
- Taylor Barbara S.
- Taylor Brandie
- Tedder-Edwards Sharita
- Teherani Meghan
- Theodore Deborah A.
- Thessing Jeffrey
- Thomas Meagan
- Thomas-Seaton LaTeshia
- Thompson Amy
- Thompson Karl M.
- Thompson-Seim Teri
- Thomsen Isaac
- Tieu Hong V.
- Toma Ramy J.
- Tomaszewski Christian
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- Tong Xiaomi
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- Torres Julian A.
- Tovar Dalia
- Tran Carolyn
- Treanor John J.
- Tukuru Sade
- Turley Christine B.
- Turner Mark A.
- Tyson Stefanie
- Ulrich Robert J.
- Usdan Lisa S.
- Utz Gregory C.
- Vachris Timothy P.
- Valenti Bruno
- Valika Insiya
- Van Der Leden Mimi
- Van Dromme Ilse
- Van Ever Wesley
- Van Roey Griet
- Varughese Tilly
- Vega Jocelyn Zuleica Olmos
- Vega Norma
- Vegas Diana
- Vertucci Michele
- Viar Veronica
- Viens Nicholas A.
- Villegas Marysol
- Vingerhoets Johan
- Vogler Mary
- Vowell Mandy
- Vrbicky Keith W.
- Wahlin Tami
- Wakefield Paul H.
- Wald Anna
- Walker James
- Walker Shannon
- Walsh Edward E.
- Walsh Mary C.
- Walsh Stephen R.
- Walsh Stephen R.
- Walter Emmanuel B.
- Walters Ayanna
- Wang Tina
- Warden Ashley
- Waters Michael
- Watkins Breanz
- Webb Angella
- Webster Hala
- Weidler Jessica L.
- Weiss Thomas
- Wells Margaret
- Wendell Lewis III
- Wendrow Andrea
- Werne Melody
- West Whitney
- Whatley Jordan L.
- Whitaker Jennifer A.
- White Jewel J.
- White Julie
- White Toni
- Wijewardane Priyantha N.
- Wilkin Timothy
- Wilkinson Bethanie
- William S. Davis Jr
- Williams Barton G.
- Williams Hayes
- Williams Samantha
- Wilson Christine
- Wilson Clint
- Wilson Greg
- Wilson Natasha
- Winbigler Jennifer
- Winkle Peter J.
- Winokur Patricia L.
- Witbeck John
- Wohl David
- Woo Wayne
- Woodside Leana
- Wortman Glenn
- Wu Yi H.
- Wylie Paul E.
- Yang Fan
- Yang Kinara S.
- Yoon Anelgine C.
- York Jill
- Young Cheryl
- Yu Chenchen
- Yusin Joseph
- Zapata Luz
- Zash Rebecca
- Zegarra Eneyda Giuvanela Llerena
- Zemanek Arthur L.
- Zenlea Kate
- Zepeda Karla
- Zervos Marcus J.
- Zhai Nan
- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
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- Brit Sovic
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- Brittany Stewart
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- Bruce G. Rankin
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- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
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- Carl P. Griffin
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- Carlos del Rio
- Carlos Lopez
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- Chenchen Yu
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- Paul H. Wakefield
- Paul J. Nugent
- Paul Kilgore
- Paul Nee
- Paul Pickrell
- Paul S. Bradley
- Paulina Miller
- Paulina Rebolledo
- Pavitra Roychoudhury
- Peta-Gay Jackson-Booth
- Pete Ducheneaux
- Peter B. Gilbert
- Peter J. Winkle
- Peter Ronco
- Philip Ponce
- Phillip Claybrook
- Phillip Levy
- Pink Folmar
- Priti Patel
- Priyantha N. Wijewardane
- Purvi Parikh
- R. Michelle Chouteau
- R. Scott McClelland
- Rachael McClennen
- Rachel Rokser
- Rafael Calderon
- Rafael Lupercio
- Rafael Mendoza
- Rajan Merchant
- Rajesh K. Davit
- Rambod Rouhbakhsh
- Ramin Herati
- Ramy J. Toma
- Raphael J. Landovitz
- Raymond Cornelison
- Rebecca Boas
- Rebecca J. Kurnat
- Rebecca P. Madan
- Rebecca Pitotti
- Rebecca Zash
- Rebone M. Maboa
- Renea Henderson
- Reuben Martinez
- Reza Parungao
- Rhodna Fouts
- Rica Santiago
- Richard Calderone
- Richard Gorman
- Richard L. Gibson
- Richard M. Glover II
- Richard M. Novak
- Richard Powell
- Richard Rupp
- Richard Starlin
- Rickey D. Manning
- Riemke Brakema
- Ripley R. Hollister
- Robert Brownlee
- Robert J. Buynak
- Robert J. Ulrich
- Robert Jeanfreau
- Robert L. Atmar
- Robert M. Grossberg
- Robert Riesenberg
- Robert S. Call
- Robert Samuels
- Robert Schmidt
- Robert Striker
- Robert W. Coombs
- Robert W. Frenck Jr.
- Roberto A. Viau Colindres
- Roberto C. Arduino
- Robin Hilder
- Robin Mason
- Robyn Hartvickson
- Rodney E. Sturgeon
- Roger J. Bedimo
- Rola G. Rucker
- Ronald Ackerman
- Ronald Lubelchek
- Roni Gray
- Rosa MacBryde
- Rosa Negron
- Rosamond Hong
- Rosario Sanchez
- Rozeli Shelly
- Rusty Greene
- Ruth Paiano
- Ruth S. Pinilla
- Ryan C. Maves
- Ryan Israelsen
- Ryan Little
- Ryan P. Starr
- Ryan Tomlinson
- S. Hasan Naqvi
- Saadia Khizer
- Sabina Raja
- Sade Tukuru
- Sally Eppenbach
- Samantha Williams
- Samira Shairi
- Sandra Erickson
- Sandra Janeth Ortega Domínguez
- Sandra Kelman
- Sandra Shelton
- Sarah Afework
- Sarah Dzigiel
- Sarah E. Rutstein
- Sarah Galloway
- Sarah Gordon
- Sarah M. Ingalsbe-Geno
- Sarah Omodele
- Satoshi Kamidani
- Sauda Muhammad
- Scott Borgetti
- Scott Kahney
- Scott N. Syndergaard
- Sebastian Garcia Escallon
- Secia Díaz-Miralrio
- Sergio E. Recuenco
- Sha-Wanda Richmond
- Shamika Huskey
- Shana Harshell
- Shanda Gower
- Shane G. Christensen
- Shannen Seversen
- Shannon Rodman
- Shannon Walker
- Sharine Phan
- Sharita Tedder-Edwards
- Sharon A. Riddler
- Sharon E. Frey
- Sharon Kohrs
- Sharon Nachman
- Sharzhaad Molina Guizar
- Shashi Kapadia
- Shauna H. Gunaratne
- Sheetal Kandiah
- Shelby Olds
- Shelby Pickle
- Sherif Naguib
- Sherrie Baker
- Sherry Lamberth
- Sheryl L. Henderson
- Shireen H. Jaffer
- Shishir K. Khetan
- Shivanjali Shankaran
- Shobha Swaminathan
- Sigridh Muñoz-Gómez
- Siham Mahgoub
- Sikhongi Phungwayo
- Silvano Omar Martínez Pérez
- Simbarashe G. Takuva
- Simmy Pinto
- Sinikka L. Green
- Sonal Munsiff
- Sonia Guerrero
- Sonja Neumeister
- Spyros A. Kalams
- Srilatha Edupuganti
- Stacy Ford
- Stacy Slechta
- Stanford Plavin
- Stefanie Mott
- Stefanie Tyson
- Stephan C. Sharp
- Stephan Hong
- Stephanie Andree
- Stephanie Rolsma
- Stephanie Skipper
- Stephanie Sterling
- Stephen A. Spector
- Stephen Daniels
- Stephen Morris
- Stephen R. Walsh
- Stephen R. Walsh
- Steve Clemons
- Steven E. Carsons
- Steven Palmer
- Steven Shinn
- Steven Shoptaw
- Steven Sperber
- Stuart H. Cohen
- Surisday Mederos
- Susan Jeanfreau
- Susan Kline
- Susan L. Koletar
- Susan Parker
- Susanne Doblecki-Lewis
- Suzanna Studdard
- Suzanne Fiorillo
- Suzanne Gharib
- Suzanne Swan
- Sybil G. Hosek
- Szheckera Fearon
- Tamara Richards
- Tambra Dora
- Tameika Scott
- Tami Wahlin
- Tammi L. Shlotzhauer
- Tana Bourgeois
- Tanya Hutchins
- Taryn Petty
- Tatiana Beresnev
- Tavane Harrison
- Taylor Nelson
- Teletha Gipson
- Teresa A. Batteiger
- Teresa Becker
- Teresa Deese
- Teresa S. Sligh
- Teri Thompson-Seim
- Terri Moye
- Terry D. Klein
- Terry L. Poling
- Terry Piedra
- Theresa Hegmann
- Thomas B. Campbell
- Thomas C. Klein
- Thomas C.S. Martin
- Thomas Mellman
- Thomas Patterson
- Thomas Weiss
- Tiffany Esinhart
- Tiffany Nemecek
- Tiffany Schwasinger-Schmidt
- Tilly Varughese
- Timothy J. Hatlen
- Timothy P. Vachris
- Timothy Shope
- Timothy W. Schacker
- Timothy Wilkin
- Tina Tong
- Tina Wang
- Toby Briskin
- Todd Simmons
- Tom Fiel
- Toni Robinson
- Toni White
- Tracy Okonya
- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health