Steady shear flow of magnetic fiber suspensions: theory and comparison with experiments

International audienceThis paper is focused on the rheology of magnetic fiber suspensions in the presence of a magnetic field applied perpendicular to the flow. At low Mason numbers, Mn<0.1, the experimental flow curves show a steep initial section corresponding to the inclination and stretching of the gap-spanning aggregates formed upon magnetic field application. At higher Mason numbers, aggregates no longer stick to the walls and the flow curves reach a Bingham regime, with the dynamic yield stress growing with the magnetic field intensity. This yield stress appears to be about three times higher for the fiber suspensions than for the suspensions of spherical particles. Such difference, measured at relatively low magnetic field intensities, H0<30 kA/m, is explained in terms of the enhanced magnetic susceptibility of the aggregates composed of fibers compared to the aggregates composed of spherical particles. For weak magnetic fields, the forces of solid friction between fibers are expected to play a minor role on the stress level of the suspension. In order to confirm these findings, we propose a new theoretical model, taking into account hydrodynamic interactions. The flow curve and the yield stress predictions are in a good agreement with the experimental results for semi-diluted suspensions

Biocompatible magnetic core–shell nanocomposites for engineered magnetic tissues

International audienceThe inclusion of magnetic nanoparticles into biopolymer matrixes enables the preparation of magnetic field-responsive engineered tissues. Here we describe a synthetic route to prepare biocompatible core– shell nanostructures consisting of a polymeric core and a magnetic shell, which are used for this purpose. We show that using a core–shell architecture is doubly advantageous. First, gravitational settling for core– shell nanocomposites is slower because of the reduction of the composite average density connected to the light polymer core. Second, the magnetic response of core–shell nanocomposites can be tuned by changing the thickness of the magnetic layer. The incorporation of the composites into biopolymer hydrogels containing cells results in magnetic field-responsive engineered tissues whose mechanical properties can be controlled by external magnetic forces. Indeed, we obtain a significant increase of the viscoelastic moduli of the engineered tissues when exposed to an external magnetic field. Because the composites are functionalized with polyethylene glycol, the prepared bio-artificial tissue-like constructs also display excellent ex vivo cell viability and proliferation. When implanted in vivo, the engineered tissues show good biocompatibility and outstanding interaction with the host tissue. Actually, they only cause a localized transitory inflammatory reaction at the implantation site, without any effect on other organs. Altogether, our results suggest that the inclusion of magnetic core–shell nanocomposites into biomater-ials would enable tissue engineering of artificial substitutes whose mechanical properties could be tuned to match those of the potential target tissue. In a wider perspective, the good biocompatibility and magnetic behavior of the composites could be beneficial for many other applications