3,612 research outputs found

    Control over stress induces plasticity of individual prefrontal cortical neurons: A conductance-based neural simulation

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    Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience. We found that control over stress induces plasticity of the intrinsic voltage-gated conductances of pyramidal neurons in the PFC. To gain insight into the underlying biophysical mechanisms of this plasticity we used the conductance- based neural simulation software tool, NEURON, to model the increase in membrane excitability associated with resilience to stress. A ball and stick multicompartment conductance-based model was used to realistically fit passive and active data traces from prototypical pyramidal neurons in neurons in rats with control over tail shock stress and those lacking control. The results indicate that the plasticity of membrane excitability associated with control over stress can be attributed to an increase in Na+ and Ca2+ T-type conductances and an increase in the leak conductance. Using simulated dendritic synaptic inputs we observed an increase in excitatory postsynaptic summation and amplification resulting in elevated action potential output. This realistic simulation suggests that control over stress enhances the output of the PFC and offers specific testable hypotheses to guide future electrophysiological mechanistic studies in animal models of resilience and vulnerability to stress

    Dynamic facilitation explains democratic particle motion of metabasin transitions

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    Transitions between metabasins in supercooled liquids seem to occur through rapid "democratic" collective particle rearrangements. Here we show that this apparent homogeneous particle motion is a direct consequence of dynamic facilitation. We do so by studying metabasin transitions in facilitated spin models and constrained lattice gases. We find that metabasin transitions occur through a sequence of locally facilitated events taking place over a relatively short time frame. When observed on small enough spatial windows these events appear sudden and homogeneous. Our results indicate that metabasin transitions are essentially "non-democratic" in origin and yet another manifestation of dynamical heterogeneity in glass formers.Comment: 6 pages, 6 figure

    Re-ordering connections: UK healthcare workers' experiences of emotion management during the COVID-19 pandemic

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    This paper examines the impact of disruptions to the organisation and delivery of healthcare services and efforts to re-order care through emotion management during the COVID-19 pandemic in the UK. Framing care as an affective practice, studying healthcare workers' (HCWs) experiences enables better understanding of how interactions between staff, patients and families changed as a result of the pandemic. Using a rapid qualitative research methodology, we conducted interviews with frontline HCWs in two London hospitals during the peak of the first wave of the pandemic and sourced public accounts of HCWs' experiences of the pandemic from social media (YouTube and Twitter). We conducted framework analysis to identify key factors disrupting caring interactions. Fear of infection and the barriers of physical distancing acted to separate staff from patients and families, requiring new affective practices to repair connections. Witnessing suffering was distressing for staff, and providing a 'good death' for patients and communicating care to families was harder. In addition to caring for patients and families, HCWs cared for each other. Infection control measures were important for limiting the spread of COVID-19 but disrupted connections that were integral to care, generating new work to re-order interactions

    Escape distance and escape latency following simulated rapid bird attacks in an Andean lizard, Phymaturus williamsi

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    Predatory birds represent the greatest risk for many lizard species. However, little is known about the functional relationship between the escape distance and escape latency of lizards during a rapid bird attack. We hypothesised that escape latency and distance in the Andean lizard species Phymaturus williamsi would increase proportionally, but vary according to the means of escape. Over a three-year period we observed seven types of antipredatory behaviour in 98% P. williamsi lizards on simulated predatory bird attacks. Escape distance and latency were positively correlated. 65% of lizards emerged from their refuge within 2 min of an attack. All of these behaviours were positively correlated with escape latency and distance, although we found the former to be more precise. This study contributes to a better understanding of the general antipredatory behaviour in this species of Andean lizard, and will assist in future decisions concerning its conservation.Fil: Fava, Gustavo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: Acosta, Juan Carlos. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales; Argentin

    A search for stellar tidal streams around Milky Way analogues from the SAGA sample

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    Context. Stellar tidal streams are the result of tidal interactions between a central galaxy and lower mass systems like satellite galaxies or globular clusters. For the Local Group, many diffuse substructures have been identified and their link to the galaxy evolution has been traced. However it cannot be assumed that the Milky Way or M31 are representative of their galaxy class, and a larger sample of analogue galaxies beyond the Local Group is required to be able to generalise the underlying theory. Aims. We want to characterise photometrically the stellar streams around Milky Way analogues in the local Universe with the goal to deepen our understanding of the interaction between host and satellite galaxies, and ultimately of the galaxy formation and evolution processes. Methods. In the present work we identified and analysed stellar tidal streams around Milky Way analogue galaxies from the SAGA sample, using deep images of the DESI Legacy Imaging Surveys (for this sample, we obtain a range of r-band surface brightness limit between 27.8 and 29 mag / arcsec2). We measure the surface brightness and colours of the detected streams using GNU Astronomy Utilities software. Results. We identified 16 new stellar tidal streams around Milky Way analogue galaxies at distances between 25 and 40 Mpc. Applying statistical analysis to our findings for the SAGA II galaxy sample, we obtained a frequency of 12.2% +/- 2.4% for stellar streams. We measured surface brightness and colours of the detected streams, and the comparison to the dwarf satellite galaxies population around galaxies belonging to the same SAGA sample shows that the mean colour of the streams is 0.20 mag redder than that of the SAGA satellites; also, the streams are, in average, 0.057 +/- 0.021 mag redder that their progenitor, for those cases when a likely progenitor could be identified.Comment: 5 pages, 3 figures, 2 table

    Modelling of content-aware indicators for effective determination of shot boundaries in compressed MPEG videos

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    In this paper, a content-aware approach is proposed to design multiple test conditions for shot cut detection, which are organized into a multiple phase decision tree for abrupt cut detection and a finite state machine for dissolve detection. In comparison with existing approaches, our algorithm is characterized with two categories of content difference indicators and testing. While the first category indicates the content changes that are directly used for shot cut detection, the second category indicates the contexts under which the content change occurs. As a result, indications of frame differences are tested with context awareness to make the detection of shot cuts adaptive to both content and context changes. Evaluations announced by TRECVID 2007 indicate that our proposed algorithm achieved comparable performance to those using machine learning approaches, yet using a simpler feature set and straightforward design strategies. This has validated the effectiveness of modelling of content-aware indicators for decision making, which also provides a good alternative to conventional approaches in this topic

    Multi-pixel high-resolution three-dimensional imaging radar

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    A three-dimensional imaging radar operating at high frequency e.g., 670 GHz radar using low phase-noise synthesizers and a fast chirper to generate a frequency-modulated continuous-wave (FMCW) waveform, is disclosed that operates with a multiplexed beam to obtain range information simultaneously on multiple pixels of a target. A source transmit beam may be divided by a hybrid coupler into multiple transmit beams multiplexed together and directed to be reflected off a target and return as a single receive beam which is demultiplexed and processed to reveal range information of separate pixels of the target associated with each transmit beam simultaneously. The multiple transmit beams may be developed with appropriate optics to be temporally and spatially differentiated before being directed to the target. Temporal differentiation corresponds to a different intermediate frequencies separating the range information of the multiple pixels. Collinear transmit beams having differentiated polarizations may also be implemented

    Symmetry Breaking and False Vacuum Decay after Hybrid Inflation

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    We discuss the onset of symmetry breaking from the false vacuum in generic scenarios in which the mass squared of the symmetry breaking (Higgs) field depends linearly with time, as it occurs, via the evolution of the inflaton, in models of hybrid inflation. We show that the Higgs fluctuations evolve from quantum to classical during the initial stages. This justifies the subsequent use of real-time lattice simulations to describe the fully non-perturbative and non-linear process of symmetry breaking. The early distribution of the Higgs field is that of a smooth classical gaussian random field, and consists of lumps whose shape and distribution is well understood analytically. The lumps grow with time and develop into ``bubbles'' which eventually collide among themselves, thus populating the high momentum modes, in their way towards thermalization at the true vacuum. With the help of some approximations we are able to provide a quasi-analytic understanding of this process.Comment: 33 pages, 16 figures, LaTeX, uses revtex. Version to be published in Phys. Rev. with minor change
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