4,104 research outputs found
Improving Conversational Passage Re-ranking with View Ensemble
This paper presents ConvRerank, a conversational passage re-ranker that
employs a newly developed pseudo-labeling approach. Our proposed view-ensemble
method enhances the quality of pseudo-labeled data, thus improving the
fine-tuning of ConvRerank. Our experimental evaluation on benchmark datasets
shows that combining ConvRerank with a conversational dense retriever in a
cascaded manner achieves a good balance between effectiveness and efficiency.
Compared to baseline methods, our cascaded pipeline demonstrates lower latency
and higher top-ranking effectiveness. Furthermore, the in-depth analysis
confirms the potential of our approach to improving the effectiveness of
conversational search.Comment: SIGIR 202
TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
<p>Abstract</p> <p>Background</p> <p><it>TNFRSF11B </it>computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy.</p> <p>Methods</p> <p>By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID) we identified and constructed significant molecule <it>TNFRSF11B </it>development network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726.</p> <p>Results</p> <p>Our result verified <it>TNFRSF11B </it>developmental process only in the downstream of frontal cortex of HIVE-control patients (<it>BST2, DGKG, GAS1, PDCD4, TGFBR3, VEZF1 </it>inhibition), whereas in the upstream of frontal cortex of HIVE (<it>DGKG, PDCD4 </it>activation) and downstream (<it>CFDP1, DGKG, GAS1, PAX6 </it>activation; <it>BST2, PDCD4, TGFBR3, VEZF1 </it>inhibition). Importantly, we datamined that <it>TNFRSF11B </it>development cluster of HIVE is involved in T-cell mediated immunity, cell projection organization and cell motion (only in HIVE terms) without apoptosis, plasma membrane and kinase activity (only in HIVE-control patients terms), the condition is vital to inflammation, brain morphology and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE include developmental process, signal transduction, negative regulation of cell proliferation, RNA-binding, zinc-finger, cell development, positive regulation of biological process and cell differentiation.</p> <p>Conclusions</p> <p>We deduced the stronger <it>TNFRSF11B </it>development network in HIVE consistent with our number computation. It would be necessary of the stronger <it>TNFRSF11B </it>development function to inflammation, brain morphology and cognition of HIVE.</p
Low rank approximation method for perturbed linear systems with applications to elliptic type stochastic PDEs
In this paper, we propose a low rank approximation method for efficiently
solving stochastic partial differential equations. Specifically, our method
utilizes a novel low rank approximation of the stiffness matrices, which can
significantly reduce the computational load and storage requirements associated
with matrix inversion without losing accuracy. To demonstrate the versatility
and applicability of our method, we apply it to address two crucial uncertainty
quantification problems: stochastic elliptic equations and optimal control
problems governed by stochastic elliptic PDE constraints. Based on varying
dimension reduction ratios, our algorithm exhibits the capability to yield a
high precision numerical solution for stochastic partial differential
equations, or provides a rough representation of the exact solutions as a
pre-processing phase. Meanwhile, our algorithm for solving stochastic optimal
control problems allows a diverse range of gradient-based unconstrained
optimization methods, rendering it particularly appealing for computationally
intensive large-scale problems. Numerical experiments are conducted and the
results provide strong validation of the feasibility and effectiveness of our
algorithm
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