Two Methods for Spoofing-Aware Speaker Verification: Multi-Layer Perceptron Score Fusion Model and Integrated Embedding Projector

The use of deep neural networks (DNN) has dramatically elevated the performance of automatic speaker verification (ASV) over the last decade. However, ASV systems can be easily neutralized by spoofing attacks. Therefore, the Spoofing-Aware Speaker Verification (SASV) challenge is designed and held to promote development of systems that can perform ASV considering spoofing attacks by integrating ASV and spoofing countermeasure (CM) systems. In this paper, we propose two back-end systems: multi-layer perceptron score fusion model (MSFM) and integrated embedding projector (IEP). The MSFM, score fusion back-end system, derived SASV score utilizing ASV and CM scores and embeddings. On the other hand,IEP combines ASV and CM embeddings into SASV embedding and calculates final SASV score based on the cosine similarity. We effectively integrated ASV and CM systems through proposed MSFM and IEP and achieved the SASV equal error rates 0.56%, 1.32% on the official evaluation trials of the SASV 2022 challenge.Comment: 5 pages, 4 figures, 5 tables, accepted to 2022 Interspeech as a conference pape

Electro-optic properties of a homeotropic liquid crystal cell with 90 degrees surface rubbings and a reverse-handed chiral dopant

The electro-optic properties of a 90 degrees twisted-homeotropic liquid crystal (LC) cell with a chiral dopant whose handedness is opposite to the LC twist are studied. In the voltage-off state, the LC directors exhibit a homeotropic alignment. However, in the intermediate voltage state, the bulk LC directors behave like a homogeneous alignment due to the balanced torques between the electric field, surface anchoring, and reversed chiral dopant. Potential applications of this mode for liquid crystal displays, especially for dual-cell-gap transflective liquid crystal displays, are emphasized

Transflective Liquid Crystal Display

The apparatus, methods, system and devices of the present invention provides transflective LCD system structure wherein each pixel is composed of at least three reflective sub-pixels and at least one transmissive sub-pixel. The reflective sub-pixels have a color filter layer for displaying color reflective images and the transmissive sub-pixel it is driven by color sequential imaging method for displaying a color transmissive image. The configuration of the sub-pixels and the location of the sub-pixel electronics increases the aperture ratio of both transmissive sub-pixel and reflective sub-pixel to improve the image brightness and lower the overall power consumption of the device

Transflective Liquid Crystal Display

The apparatus, methods, system and devices of the present invention provides transflective LCD system structure wherein each pixel is composed of at least three reflective sub-pixels and at least one transmissive sub-pixel. The reflective sub-pixels have a color filter layer for displaying color reflective images and the transmissive sub-pixel it is driven by color sequential imaging method for displaying a color transmissive image. The configuration of the sub-pixels and the location of the sub-pixel electronics increases the aperture ratio of both transmissive sub-pixel and reflective sub-pixel to improve the image brightness and lower the overall power consumption of the device

The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome

<p>Abstract</p> <p>Background</p> <p>A <it>tumor necrosis factor-alpha </it>is a multifunctional pro-inflammation cytokine, which has been considered as one of pathogenic factors for various diseases. The promoter -1031(T/C) polymorphism in the <it>tumor necrosis factor-alpha </it>gene was reported that it plays a part in reproduction-related diseases. Among these, polycystic ovary syndrome (PCOS) is known to be a common gynecological disease of women in reproductive age women. Here, we performed a comparative study of -1031(T/C) polymorphism of <it>TNF-alpha </it>gene with PCOS in a Korean population.</p> <p>Methods</p> <p>The -1031(T/C) polymorphism of <it>TNF-alpha </it>gene was analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in a total of 217 PCOS patients and 144 matched female controls of healthy women. And statistical analysis was performed using HapAnalyzer. <it>X</it>²test and logistic regression were utilized analyze the association between two groups. A <it>p</it>-value under 0.05 was considered statistically significant.</p> <p>Results</p> <p>The genotype and allelic frequencies were in Hardy-Weinberg equilibrium (HWE). There was strong association between the -1031(T/C) polymorphism in the promoter region of <it>TNF-alpha </it>gene and PCOS (<it>p</it>-value = 0.0003, odd ratio (OR) = 2.53). In addition, the frequency of C allele was significantly higher in PCOS patients compared with controls. Sequence analyses also showed the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene.</p> <p>Conclusion</p> <p>This is the first study on the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene in PCOS. We concluded that the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene is associated with PCOS in a Korean population. Therefore, it is possible that it may be considered as a clinical biomarker to diagnose for PCOS, and is helpful in understanding the etiology for the pathogenesis of PCOS.</p

Liquid Crystal Display with Different Twisting Directions of Liquid Crystal Molecules

A liquid crystal display includes a first alignment film having a first alignment direction, a second alignment film having a second alignment direction, and a liquid crystal layer having liquid crystal molecules between the first and second alignment films. The liquid crystal layer is doped with a chiral material that tends to induce a first twist in directors of the liquid crystal molecules when an electric field is applied to the liquid crystal layer. The first and second alignment films have orientations that tends to induce a second twist in the directors when an electric field is applied to the liquid crystal layer, in which the direction of the first twist is different from the direction of the second twist

Radiofrequency Ablation of Thyroid Nodules: Basic Principles and Clinical Application

Radiofrequency (RF) ablation has been gaining popularity as a minimally invasive treatment for benign thyroid nodules regardless of the extent of the solid component. RF ablation of benign nodules demonstrated volume reductions of 33–58% after one month and 51–85% after six months, while solving nodule-related clinical problems. RF ablation has recently shown positive short-term results for locoregional control as well as symptom improvement in patients with recurrent thyroid cancers. This paper reviews the basic physics, indications, patient preparation, devices, procedures, clinical results, and complications of RF ablation

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability

BACKGROUND: Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in the ubiquitin-dependent degradation pathway. RESULTS: While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys, His, and Asp domains which are responsible for the deubiquitinating activity. Biochemical enzyme assays indicated that they have deubiquitinating activity. Interestingly, the sequence analysis showed that these proteins, with exception of USP17N, contain the putative hyaluronan/RNA binding motifs, and cetylpyridinium chloride (CPC)-precipitation analysis confirmed the association between these proteins and intracellular hyaluronan and RNA. CONCLUSION: Here, we report that the overexpression of these proteins, with exception of USP17N, leads to apoptosis, suggesting that the hyaluronan and RNA binding motifs in these enzymes play an important role in regulating signal transduction involved in cell death